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LOCUS XM_017157466 2615 bp mRNA linear INV 09-DEC-2024 protein-coupled receptor 4 (Lgr4), mRNA. ACCESSION XM_017157466 VERSION XM_017157466.3 DBLINK BioProject: PRJNA1194641 KEYWORDS RefSeq. SOURCE Drosophila takahashii ORGANISM Drosophila takahashii Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. COMMENT MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_091683) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Dec 9, 2024 this sequence version replaced XM_017157466.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_030179915.1-RS_2024_12 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 12/07/2024 ##Genome-Annotation-Data-END## FEATURES Location/Qualifiers source 1..2615 /organism="Drosophila takahashii" /mol_type="mRNA" /strain="IR98-3 E-12201" /db_xref="taxon:29030" /chromosome="X" /sex="female" /tissue_type="Whole fly" /dev_stage="Adult fly" /collected_by="Originally obtained from EHIME-Fly" gene 1..2615 /gene="Lgr4" /note="Leucine-rich repeat-containing G protein-coupled receptor 4; Derived by automated computational analysis using gene prediction method: Gnomon. Supporting evidence includes similarity to: 4 Proteins" /db_xref="GeneID:108068072" CDS 231..2615 /gene="Lgr4" /codon_start=1 /product="relaxin receptor 2" /protein_id="XP_017012955.2" /db_xref="GeneID:108068072" /translation="MSIAIMRLPIVLSILLALTSNAAATGTATESTRTGIGTKPETEM EVEAKEVISLLGAIDGIESVVLVPDSGDKCPGGYFHCNTTAQCVPQRANCDGTVDCDD RSDELNCVNEVDAKYWDHLYRKQTFGTNDDLRIGECQWRNENFSCPCRGHEMLCRFQQ LTVIPALLPQNDLVTLDLTGNNFETIHETFFSELPDMEILVLKFCSIREIASHAFDRL ADSPLKTLYMDDNKLPHLPEHFFPEGNQLRILILARNRLHHLKRSDFRNLQQLEELDL RGNRIGNFEAEVFAQLPSLEKLYLNENHLKRLDPERFPRTLLNLQTLSLDHNQIEDIA ANTFPFPRLRHLYLAGNRLSHIRDETFCNLSNLQGLHLNENRIEGFDLEAFACLKNLS SLLLTGNRFQTLDPRVLKNLSSLDYIYFSWFHLCSAAMSVRVCSPHGDGISSKLHLLD NQILRGSVWVMASIAVVGNLLVLLGRYFYKSRSNVEHSLYLRHLAASDFLMGIYLTLI ACADISFRGEYIKYEEAWRHSGICAFAGFLSTFSCQSSTLLLTLVTWDRLMSVTRPLK PRDTEKVRIVLRLLLLWGISFGLAAAPLLPNPYFGSHFYGNNGVCLSLHIHDPYAKGW EYSALLFILVNTLSLVFILFSYIRMLQAIRDSGGGMRSTHSGRENVVATRFAIIVTTD CACWLPIIVVKVAALSGCDISPDLYAWLAVLVLPVNSALNPVLYTLTTAAFKQQLRRY CHTLPSCSLVNNETRSQTQTAYESGLSVSLAHLGGGVGGGSGRKRMSHRQMSYL" misc_feature 450..557 /gene="Lgr4" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(465..467,492..494,525..530) /gene="Lgr4" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(504..506,513..515,525..527,543..548) /gene="Lgr4" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 534..548 /gene="Lgr4" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 687..>1475 /gene="Lgr4" /note="Leucine-rich repeat (LRR) protein [Transcription]; Region: LRR; COG4886" /db_xref="CDD:443914" misc_feature 747..818 /gene="Lgr4" /note="leucine-rich repeat [structural motif]; Region: leucine-rich repeat" /db_xref="CDD:275380" misc_feature 819..890 /gene="Lgr4" /note="leucine-rich repeat [structural motif]; Region: leucine-rich repeat" /db_xref="CDD:275380" misc_feature 897..968 /gene="Lgr4" /note="leucine-rich repeat [structural motif]; Region: leucine-rich repeat" /db_xref="CDD:275380" misc_feature 969..1040 /gene="Lgr4" /note="leucine-rich repeat [structural motif]; Region: leucine-rich repeat" /db_xref="CDD:275380" misc_feature 1041..1112 /gene="Lgr4" /note="leucine-rich repeat [structural motif]; Region: leucine-rich repeat" /db_xref="CDD:275380" misc_feature 1113..1187 /gene="Lgr4" /note="leucine-rich repeat [structural motif]; Region: leucine-rich repeat" /db_xref="CDD:275380" misc_feature 1188..1256 /gene="Lgr4" /note="leucine-rich repeat [structural motif]; Region: leucine-rich repeat" /db_xref="CDD:275380" misc_feature 1257..1328 /gene="Lgr4" /note="leucine-rich repeat [structural motif]; Region: leucine-rich repeat" /db_xref="CDD:275380" misc_feature 1329..1400 /gene="Lgr4" /note="leucine-rich repeat [structural motif]; Region: leucine-rich repeat" /db_xref="CDD:275380" misc_feature 1401..1466 /gene="Lgr4" /note="leucine-rich repeat [structural motif]; Region: leucine-rich repeat" /db_xref="CDD:275380" misc_feature 1584..2441 /gene="Lgr4" /note="relaxin family peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Region: 7tmA_Relaxin_R; cd15137" /db_xref="CDD:320265" misc_feature 1587..1667 /gene="Lgr4" /note="TM helix 1 [structural motif]; Region: TM helix 1" /db_xref="CDD:320265" misc_feature 1689..1766 /gene="Lgr4" /note="TM helix 2 [structural motif]; Region: TM helix 2" /db_xref="CDD:320265" misc_feature order(1752..1754,1761..1766,1824..1841,1845..1850, 1857..1859,1989..1991,1995..2009,2097..2099,2106..2114, 2118..2126,2130..2135,2286..2288,2295..2300,2304..2309, 2316..2318,2340..2345,2349..2357,2364..2366,2373..2378) /gene="Lgr4" /note="putative peptide ligand binding pocket [polypeptide binding]; other site" /db_xref="CDD:320265" misc_feature 1824..1916 /gene="Lgr4" /note="TM helix 3 [structural motif]; Region: TM helix 3" /db_xref="CDD:320265" misc_feature 1947..2015 /gene="Lgr4" /note="TM helix 4 [structural motif]; Region: TM helix 4" /db_xref="CDD:320265" misc_feature 2097..2186 /gene="Lgr4" /note="TM helix 5 [structural motif]; Region: TM helix 5" /db_xref="CDD:320265" misc_feature 2226..2318 /gene="Lgr4" /note="TM helix 6 [structural motif]; Region: TM helix 6" /db_xref="CDD:320265" misc_feature 2343..2420 /gene="Lgr4" /note="TM helix 7 [structural motif]; Region: TM helix 7" /db_xref="CDD:320265" ORIGIN 1 cagttgtttg ttatcgttgg caccgaacgc gcggcaccgc ggactgaaaa tcgggtcgac 61 tgaaagtcga gtgatctact tgtatatttt tggatccccg aacgatctca cattgaagtg 121 cggcgaagtt gtattttttt tttgcctttt ttttgccgtg cccatcgaag tctataatta 181 aatattgttt attacccgtt aaatcggcgg aagagcggag aactccctgg atgtcaatag 241 cgatcatgcg actccccatt gttctctcca tcctgctcgc actaacttct aatgcggcag 301 cgacagggac ggcaacagaa agcacacgaa cgggaatcgg aacgaaaccg gaaacggaaa 361 tggaggtgga agctaaggag gtgatatcgc tcctgggcgc aatcgatggc atcgagtccg 421 ttgtcctggt tcccgactcc ggcgacaagt gtcccggcgg ctacttccac tgcaacacga 481 cggcacaatg tgttccccag cgggccaact gcgacggaac cgtcgactgc gatgacagat 541 cggatgagtt gaactgcgtg aatgaggtgg atgccaagta ctgggaccac ctgtacagga 601 aacagacgtt cggcacgaac gacgacctgc ggattggcga gtgccagtgg cgcaacgaga 661 actttagctg tccttgccga ggtcacgaaa tgttgtgccg ctttcaacag cttaccgtta 721 ttccagcact tttgccgcag aacgatctgg taacgctcga tctaaccgga aacaatttcg 781 aaaccattca cgagaccttc ttcagtgaac tgccagacat ggagatccta gtgctgaagt 841 tctgctcaat ccgtgagatt gcctcgcatg ccttcgatcg cctggcggac agcccactga 901 agacccttta tatggacgat aataaattgc cgcatctgcc ggaacacttc tttcccgagg 961 gcaatcaatt gaggattcta attttggcac gcaaccgcct gcaccacctg aaacgcagtg 1021 attttcgaaa tctacagcaa ctggaggagc tggacctgcg cggtaatcgc attggaaact 1081 ttgaggccga ggtgtttgcc caactgccga gtttggaaaa gctctatctc aacgaaaacc 1141 acttgaagcg actggatccc gaaagatttc ccagaaccct gctcaatctg cagactctgt 1201 ccctggatca caatcagatc gaagatatag ccgccaacac atttcccttt ccgcgactta 1261 gacatttata tttggctggc aatcgattat cccacatacg agatgaaacc ttttgcaatc 1321 tcagcaatct acaaggatta cacttgaacg agaaccgcat cgagggattc gacctggagg 1381 ccttcgcctg cctgaagaac ctcagctcgc tgctgctaac gggcaatcgc tttcagaccc 1441 tcgatccgcg ggtcctaaaa aacctgagca gcctggatta tatttacttc tcgtggttcc 1501 atttgtgtag cgccgccatg agtgtgcgag tctgttcccc acatggcgac ggcatcagca 1561 gcaagttgca cctactggac aaccagatat tgagaggcag cgtttgggtg atggcctcaa 1621 ttgccgtggt gggcaacctg ctggtcctgc tggggcgcta cttctacaag tcgcggagca 1681 acgtggagca ctcgctctac ctccgccatt tggccgccag cgacttcctc atgggcattt 1741 acctgacgct gattgcctgt gcggacatta gtttccgcgg cgagtacatc aaatacgagg 1801 aggcctggcg gcacagcggc atttgcgcct tcgcaggctt cctcagcacc ttcagttgcc 1861 agtcgtcgac gctgctgctc acactggtca cctgggatcg tctgatgtct gtgacgaggc 1921 ccctgaagcc ccgagatacg gagaaagttc gaattgtcct ccgtctgttg ctcctgtggg 1981 gcattagttt tggactggct gctgctccac tcctgcccaa tccctacttt ggcagccatt 2041 tctatggcaa caacggtgtc tgcttgtccc tccacatcca cgatccctat gccaagggat 2101 gggagtactc ggcgctactg ttcatcctgg tcaacacgtt gtcactggtc ttcatcctgt 2161 tttcctacat acggatgttg caggcgatca gggattcggg cggcggaatg cggagcactc 2221 acagcggccg cgagaatgtg gtggccactc gctttgccat cattgtgacc accgattgcg 2281 cctgctggct gcccataatt gtggtcaaag tggctgccct ttcgggctgc gacatctccc 2341 ccgatctgta tgcctggctg gccgtgctgg tgctgcccgt gaactcggcc ctcaatccgg 2401 tgctctacac tctcaccacg gcggccttca agcagcagct gcgccgctac tgccacacgc 2461 tgcccagctg ctcgctggtg aacaacgaga cccgatccca aacgcagacc gcctacgagt 2521 ctggattgag cgtaagcctg gcccatttgg gtggcggagt gggcggcgga tcgggacgca 2581 agcggatgtc ccaccgacag atgagctatc tgtag