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LOCUS XM_017140651 3996 bp mRNA linear INV 09-DEC-2024 FAK (Graf), transcript variant X1, mRNA. ACCESSION XM_017140651 VERSION XM_017140651.3 DBLINK BioProject: PRJNA1194641 KEYWORDS RefSeq. SOURCE Drosophila takahashii ORGANISM Drosophila takahashii Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. COMMENT MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_091683) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Dec 9, 2024 this sequence version replaced XM_017140651.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_030179915.1-RS_2024_12 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 12/07/2024 ##Genome-Annotation-Data-END## FEATURES Location/Qualifiers source 1..3996 /organism="Drosophila takahashii" /mol_type="mRNA" /strain="IR98-3 E-12201" /db_xref="taxon:29030" /chromosome="X" /sex="female" /tissue_type="Whole fly" /dev_stage="Adult fly" /collected_by="Originally obtained from EHIME-Fly" gene 1..3996 /gene="Graf" /note="GTPase regulator associated with FAK; Derived by automated computational analysis using gene prediction method: Gnomon. Supporting evidence includes similarity to: 1 Protein" /db_xref="GeneID:108056722" CDS 446..3505 /gene="Graf" /codon_start=1 /product="rho GTPase-activating protein Graf isoform X1" /protein_id="XP_016996140.2" /db_xref="GeneID:108056722" /translation="MGGGKNIRRGLEPLEFEECIVDSPDFRENLNRHEKELDHTSHQI KRIIKEVKDLMSAAKMLSTRMKQLAILLTDFNFECIGTAQTDDENVICESLKRFGAII GNIEDEREKMLTLADKHIIESLEDFRKKQIGGVKENKKKFDKKTEKFCQSQERFLNMS TKKPENTIQEADASLGMHEREYIQESLSYVLRIQEVQERIKFEFVEILLAFISGWLVF YHTAHEQAEDHRDYLQDLRHKVQKTRENFEEAREKVTELKTKYMEKRTKPEEIFTKRG YLFLMEKSSILKISLLEPFKATWTKYYCTFKKQKREFTMLQFNQMNHNFTRPEARDDE KLTLFSCQRRASEFEKRFCFDLTFKEKPGVVYTFQALSEKDHRYWISAMDGTEPTYLA PGKIKVSEAYHLDEAGFMFIRRCIQVLEIRGLEDEGIYRKSGVGTKISKLLSLGLNQK ETDDVFVDDKYRDLMESNTIASALKMYLRNLNEPLMTYQYHSDFIEAAKQETLNQRVN EVHKLVYKLPQPNFQMLDMVICHLTDVSRKYEKNKMSVFNLGVVFGPTLLRPREESVA AILDIKFNNIVINILIDNYERIFKNKPSADVKLPVEAAKAPSIMYPARSSPPTRMPRA SQIGKAASTGAMGSTSSTAAAAAAAGNPMFLNQQKIYRVVSKSNCTEPTMSSSLQNIP NGDNYASGGAGCISLSPPMHMLNGILSPTIGSINNLHTISKNETTVGTTTAAGTRRYV PNDTAEVATDYGIIGANNGGVTLQSHHAIPVSSTTNFRHPEYLVTQSGSTNHLYTNSS SSVAGAAATSGNRISLNNVSPPNTAMRKERFLGSTGSGPQQHPPVQRGLHSYGQTKQQ QQQHYSPLMPTSTSSSNDSVCDSLSSNNGQHLGARNSNDYAMLTSQNSSLSPHLGHGS ACDEVVTATTVSCGGSANESSEYPPSKMHRNRDINQIKRDLSTGTARVRTLYACMGES EGELSFEPNQIITNVRYSHEPGWLQGTLNGKTGLIPENYVEHLKPHH" misc_feature 524..1144 /gene="Graf" /note="The Bin/Amphiphysin/Rvs (BAR) domain of Oligophrenin1-like Rho GTPase Activating Proteins; Region: BAR_RhoGAP_OPHN1-like; cd07602" /db_xref="CDD:153286" misc_feature order(551..553,560..565,575..577,581..586,593..598, 602..607,614..619,623..628,635..640,644..649,656..658, 737..739,746..751,1025..1027,1034..1039,1043..1045, 1058..1060,1067..1072,1076..1081,1091..1096,1103..1108, 1112..1117,1121..1126,1130..1135) /gene="Graf" /note="dimer interface [polypeptide binding]; other site" /db_xref="CDD:153286" misc_feature 1262..1615 /gene="Graf" /note="GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain; Region: BAR-PH_GRAF_family; cd01249" /db_xref="CDD:269953" misc_feature 1592..2197 /gene="Graf" /note="GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to...; Region: RhoGAP; cl02570" /db_xref="CDD:470621" misc_feature order(1736..1738,1868..1870,1880..1882,2087..2089, 2096..2101,2168..2170) /gene="Graf" /note="GTPase interaction site; other site" /db_xref="CDD:238090" misc_feature 1736..1738 /gene="Graf" /note="catalytic residue [active]" /db_xref="CDD:238090" misc_feature 3326..3487 /gene="Graf" /note="Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase and similar proteins; Region: SH3_GRAF-like; cd11882" /db_xref="CDD:212815" misc_feature order(3341..3343,3347..3349,3356..3358,3368..3370, 3425..3430,3467..3469,3473..3478) /gene="Graf" /note="peptide ligand binding site [polypeptide binding]; other site" /db_xref="CDD:212815" polyA_site 3996 /gene="Graf" /experiment="COORDINATES: polyA evidence [ECO:0006239]" ORIGIN 1 attaattttt ttttttctaa tcgaagattt aacagccaaa gtaatatata tattgtggtg 61 catttagaat acaattgagt gaaatgtgca attgatattg atgctgaata atatccgctg 121 gaaatccgca aagcgcgacg cggtcgactg gcgttattcg agcagggcga cattagatat 181 tgggaaatta ctcatacact aatgtttact ctgaatattt caatatgcat cgtccaccta 241 ctgaaaaaca gtatttacat tgaaacgtaa atatttaaaa ggagccagag ccactcttcc 301 tgtaaatgtt tcaaacacca cagcttcaac gcctgaatac aaatatacac catacattag 361 ccaccgcgga agaacgcagc ctgaaataac ctaaagcagc tgggcccgaa aatcttcaat 421 atttttgaaa ccaaaagcaa acacaatggg cggcggcaaa aatatacgcc gcggcttgga 481 gccactggag ttcgaggaat gcatcgtcga cagtccggac tttcgcgaaa atctaaaccg 541 acatgaaaag gagctggacc acactagtca tcaaataaaa cgaataatca aagaggtcaa 601 ggatctaatg agtgcggcaa agatgctgtc cactagaatg aaacaattgg ccattttact 661 taccgacttt aactttgagt gcataggcac tgctcagacc gacgacgaga atgtcatttg 721 cgaaagccta aaacgctttg gtgctatcat tggcaatatc gaagatgagc gcgagaaaat 781 gctaacgctc gctgacaaac atattattga gtcgctggag gattttcgaa aaaagcaaat 841 tggcggcgtc aaagaaaaca aaaagaaatt cgataagaaa acggagaaat tctgtcagtc 901 gcaggagcgt tttctcaata tgtcaactaa aaagcccgag aacacaatac aggaggctga 961 tgctagcttg ggcatgcacg aacgcgagta tatccaggag tcgctgagct atgtcctgcg 1021 gatacaggaa gtgcaggaac gaatcaaatt cgagttcgtc gagatactgc tcgcatttat 1081 ttctggctgg ttggtgttct atcacacagc ccacgaacag gcggaagatc atcgcgacta 1141 cctgcaggat ttgaggcaca aggtgcagaa gactcgcgaa aatttcgaag aggctcgcga 1201 aaaggttact gagttgaaaa caaagtacat ggaaaaacgc acaaagcccg aggagatttt 1261 cacaaagcgg ggctacctat ttttaatgga aaaaagttcc attctgaaaa tctccctttt 1321 agagccattc aaagcgacgt ggacgaaata ctattgtaca ttcaagaagc aaaagcgcga 1381 gttcacgatg ctgcagttca atcaaatgaa tcacaatttc accaggccgg aggcacgcga 1441 tgacgagaag ctgacgctct tctcgtgcca gcgaagagcc tcggagttcg agaagcgctt 1501 ctgcttcgat ttgaccttca aggagaagcc gggcgtcgtc tatacctttc aggcgctaag 1561 cgaaaaggat catcgctact ggattagcgc tatggatggc acggagccga cttatctggc 1621 gcctggtaaa atcaaagtca gcgaggcata ccatctggat gaggccggct tcatgttcat 1681 ccgccgctgc attcaagtat tagagatccg tggtctggag gacgagggga tttaccggaa 1741 gagcggtgtg ggtaccaaaa tcagcaagct gctctcgctg ggcctgaatc aaaaggaaac 1801 cgacgacgtc ttcgtggacg acaagtaccg ggatttaatg gagagcaaca ccattgccag 1861 tgccctgaaa atgtatctgc gaaatctaaa tgagcccttg atgacctatc aataccacag 1921 tgattttatt gaggcagcca agcaagaaac cctgaatcaa cgcgtgaacg aggtgcacaa 1981 gctggtctac aaattgccac agcctaattt tcagatgctg gacatggtta tttgccattt 2041 gacagacgtt tcacgaaagt acgagaagaa caagatgtcc gtattcaatc tgggcgtggt 2101 tttcggaccc actttgctgc gacctcgcga ggaatcggtg gccgccatac tggatattaa 2161 attcaacaat atcgtcatta acattctgat tgataactac gagcggatct tcaagaacaa 2221 gcccagcgcc gatgtaaagc tgcctgtgga ggccgccaag gcgccgagca ttatgtatcc 2281 cgcacgcagc agtccaccca cgcgaatgcc gcgtgcctct caaataggaa aggccgcttc 2341 gactggtgcc atgggcagta cgagcagcac tgcggcggcg gcggcagcgg cggggaatcc 2401 gatgttcctc aatcagcaga agatctaccg cgtggtcagc aaatccaatt gtacagagcc 2461 caccatgtcg tccagcctgc agaatattcc gaatggcgat aactatgctt cgggcggtgc 2521 cggctgcatt tccctgtcgc cgcccatgca tatgctgaat ggcatactct cgccgaccat 2581 cggcagcatc aacaatctgc acacaatatc gaagaacgag acgacggtag gaacgacaac 2641 ggcggcgggc acacggcgat acgttcccaa cgacacggct gaggtcgcga ccgattatgg 2701 tattataggt gccaacaatg gcggcgtgac gctgcagtcg catcatgcca tacccgtcag 2761 cagcacgacc aatttccggc atcccgagta cctagtgacc cagtcggggt cgactaatca 2821 cctatatacg aacagtagct ctagtgtcgc tggtgccgcc gctacctcag gcaatcggat 2881 tagtctgaac aacgtttccc cgccaaatac agcgatgcga aaggagagat ttctcggtag 2941 caccggcagc gggccgcagc agcatccgcc cgtccaacgg ggcctccact cgtacggcca 3001 aacgaagcag cagcagcagc agcactactc acccctgatg cccacgtcaa cgtcgagctc 3061 caacgacagc gtatgtgatt cactttcttc caataacggc cagcatttgg gcgcacgcaa 3121 ctctaatgat tatgccatgc taacgtcaca gaactcatcg ctgtcgccgc atcttggaca 3181 cggatccgcc tgcgatgagg tcgtcacggc caccaccgtc agctgcggcg gctccgccaa 3241 cgagagttcc gagtatccgc ccagcaaaat gcatcgtaat cgtgacatta accaaataaa 3301 acgtgatttg tcaacgggca cagctcgagt gcgcacactc tatgcttgca tgggcgagag 3361 cgagggggag ctttcgtttg agcccaatca aataataacc aatgttcggt attcccacga 3421 gcccggctgg ttgcagggca cactaaatgg aaaaacagga ctcattccgg agaactatgt 3481 ggaacacttg aagccccacc attagattac gctttggttc ggcttgggag ttcgaatgtt 3541 ccctcgtatt ttttgcattc gtcgttagat aaaattaaaa aaaaaacaaa aacaaaacaa 3601 aaaaatgaaa tattaggaaa tcgaaaaatg atcgttgtgt aaaaaaaact aaaactaatt 3661 tttgagtatg tgcccttggg gttgttttac atgaaatgca ttttatttta tgctggaaac 3721 caggaaacca caatcttacc ttataactat gttaaccttt ataataccat gaccatacaa 3781 tgtacttatt tttaattatt taataaggag tataaactca gtgcaactgc aaagatttat 3841 ttactaattg ttacgctctt catttgttgc ttatttatac ataattcacg taatttgtgc 3901 aaaaatgaat tacatcgtat ctaatatcta ctacatatac aattgtataa aaataaatag 3961 cagtgcttcg aacactttta aaatgtaaac tttaaa