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PREDICTED: Drosophila takahashii RAS p21 protein activator vap


LOCUS       XM_017139755            3544 bp    mRNA    linear   INV 09-DEC-2024
            (vap), transcript variant X3, mRNA.
ACCESSION   XM_017139755
VERSION     XM_017139755.3
DBLINK      BioProject: PRJNA1194641
KEYWORDS    RefSeq.
SOURCE      Drosophila takahashii
  ORGANISM  Drosophila takahashii
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_091683) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Dec 9, 2024 this sequence version replaced XM_017139755.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_030179915.1-RS_2024_12
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Gnomon; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 12/07/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3544
                     /organism="Drosophila takahashii"
                     /mol_type="mRNA"
                     /strain="IR98-3 E-12201"
                     /db_xref="taxon:29030"
                     /chromosome="X"
                     /sex="female"
                     /tissue_type="Whole fly"
                     /dev_stage="Adult fly"
                     /collected_by="Originally obtained from EHIME-Fly"
     gene            1..3544
                     /gene="vap"
                     /note="RAS p21 protein activator vap; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 8
                     Proteins"
                     /db_xref="GeneID:108056092"
     CDS             219..3083
                     /gene="vap"
                     /codon_start=1
                     /product="ras GTPase-activating protein 1"
                     /protein_id="XP_016995244.1"
                     /db_xref="GeneID:108056092"
                     /translation="MADLIHLGNIDVVIQKDKPGSPTGCSDDGNLAGLGGMSGLGGMM
                     AAGGIDLGDLAQELDHDEFDGPHMLNGERPAIIAPPESEWYHGRLDRYSAESRLRGSS
                     KLGSYLVRESDRKPGSYVLSYYGRTGINHFRITAVCGDFYIGGRQFISLSDLVGYYTS
                     CSDLLKRERLAIPVAPPEPVNDKKRVVAILPYTKMPETDELSFQKGDIFFVHNDMGDG
                     WLWVTAHRTGEQGMIFRELVDDLDVSIDPNTVFPWFHPNCTKNEAVDMLVKAGPGSFL
                     VRPSDNSPGDYSLFFHINNQIQRFRIEKKGVRYLMGGRTFECLDAVINRYRKEQIVEG
                     HSLNHPVVNGIQPEFNQQYVVEKAAEKIYATLRECRDQIGLKKIKGIKHHGHLNKKSD
                     KTTKWKQLYFALINDGSETQLCFYDNPKKTKPKGLIDLSCAYLYQCHDSLWERPYCFQ
                     IVERALPCLATVTYLCAPSQESYVEWINSLKAQCDSQLSRAQKKVSRLRELRCLNLHV
                     LEAHRLPFKLVPHPYCSISLNQVKVGKTRVKIAPEPVWEEEFVLDDVPPDVVSLTITL
                     ISRGKRGKDSEVAELTIDLSSLKNGQETEGWYQLTGMTPMGEWGSLRLRMRYLDDLIM
                     PCEEYSPLQQLLLESELYAVKALAELCHNDRVPLATALLRVFRQEKRETELIRMLCQA
                     EVTRENETTTLFRGASLATTLMDLYMRTECSGFLQSAVSETVQRILESKQSAELNPTK
                     MDVNDDACTNAEFLLQILDLVTQSIFTSPDACPRNVRFICSCLQKAVMAKWPTERLVR
                     TRVVSGFIFLRLLCPALLNPRQFGLVSETPPMAATRSLVMVAKCLQNLANLIEFGGKE
                     QYMEVVNPFILKNKERMIVFLDQLSSVNDPNQPLGMFVEQSTNLNSQDTGRELATLHH
                     ICVSHSQELHELSNILSIKKLVTVTDMLTKHKLKYREMIS"
     misc_feature    408..716
                     /gene="vap"
                     /note="N-terminal Src homology 2 (SH2) domain found in Ras
                     GTPase-activating protein 1 (GAP); Region:
                     SH2_Nterm_RasGAP; cd10353"
                     /db_xref="CDD:198216"
     misc_feature    order(489..491,546..548,609..611,615..617)
                     /gene="vap"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]; other site"
                     /db_xref="CDD:198216"
     misc_feature    order(612..614,690..692)
                     /gene="vap"
                     /note="hydrophobic binding pocket [polypeptide binding];
                     other site"
                     /db_xref="CDD:198216"
     misc_feature    765..941
                     /gene="vap"
                     /note="Src Homology 3 domain of Ras GTPase-Activating
                     Protein 1; Region: SH3_RasGAP; cd11788"
                     /db_xref="CDD:212722"
     misc_feature    972..1196
                     /gene="vap"
                     /note="C-terminal Src homology 2 (SH2) domain found in Ras
                     GTPase-activating protein 1 (GAP); Region:
                     SH2_Cterm_RasGAP; cd10354"
                     /db_xref="CDD:198217"
     misc_feature    order(996..998,1050..1052,1113..1115,1119..1121)
                     /gene="vap"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]; other site"
                     /db_xref="CDD:198217"
     misc_feature    order(1116..1118,1194..1196)
                     /gene="vap"
                     /note="hydrophobic binding pocket [polypeptide binding];
                     other site"
                     /db_xref="CDD:198217"
     misc_feature    1353..1670
                     /gene="vap"
                     /note="RAS p21 protein activator (GTPase activating
                     protein) 1 Pleckstrin homology (PH) domain; Region:
                     PH_RASA1; cd13260"
                     /db_xref="CDD:270080"
     misc_feature    1713..2084
                     /gene="vap"
                     /note="C2 domain present in RAS p21 protein activator 1
                     (RasA1); Region: C2_Ras_p21A1; cd08400"
                     /db_xref="CDD:176045"
     misc_feature    2076..3080
                     /gene="vap"
                     /note="Ras GTPase Activating Domain; Region: RasGAP;
                     cl02569"
                     /db_xref="CDD:470620"
     misc_feature    order(2181..2183,2289..2291,2295..2297,2301..2306,
                     2310..2312,2319..2321,2331..2333,2616..2618,2640..2645,
                     2652..2657,2664..2666,2727..2729,2736..2741,2748..2750,
                     2760..2762,2766..2768,2781..2786)
                     /gene="vap"
                     /note="RAS interface [polypeptide binding]; other site"
                     /db_xref="CDD:213340"
     polyA_site      3544
                     /gene="vap"
                     /experiment="COORDINATES: polyA evidence [ECO:0006239]"
ORIGIN      
        1 ttccgcgcat cactagcaat tgaattctat cgggttgtgg ctatcgctta gcacataatc
       61 atcacggaaa actgagtaca atcaccaaag cttccgtttt tcctaagtaa acgcaaagac
      121 atcgttgcta tatgtggctt ttatcaaagg gaatttcgct gaaagttaaa tatagattaa
      181 gattcccatt cactgagcag agatcataaa ggaagatcat ggcggaccta attcacttgg
      241 gaaacataga tgttgtcatc cagaaagata agcccggctc gccgacgggc tgctcggatg
      301 atggaaacct ggcaggtctg ggcggcatga gtggattggg cgggatgatg gccgccggtg
      361 gcattgatct gggtgacttg gcgcaggaat tggatcacga tgaattcgat ggaccacaca
      421 tgctaaatgg tgaacgtcca gcgattattg ctcctcccga aagtgaatgg taccacggac
      481 gacttgatcg ttactcagct gaatcacgtc tgcggggcag cagtaaactg ggaagctact
      541 tagttcgtga aagtgaccgc aagcctggct cctatgttct aagttattat gggcgtaccg
      601 gcataaacca ttttcggatc acggctgtgt gcggagactt ctatatcggt ggacgacaat
      661 tcatatcgtt gagcgatctg gttggctact atacctcatg cagtgaccta ctgaagcgcg
      721 aacgattggc cataccagtg gctccgccgg agccagttaa tgataagaag cgagtcgttg
      781 ccatcctgcc ttatacaaaa atgccagaga ccgatgagct gagcttccag aaaggtgata
      841 ttttcttcgt gcacaatgac atgggcgacg gttggctgtg ggtcactgcc catcgtactg
      901 gcgagcaggg aatgattttc cgagagcttg tggatgatct ggatgtatcc atcgatccga
      961 ataccgtctt tccgtggttt catccgaatt gcaccaaaaa cgaagctgtc gatatgttgg
     1021 ttaaagctgg acccggcagc ttcttggttc gccccagcga caactcaccg ggcgattact
     1081 ccctcttttt ccatattaac aaccagatcc aacgatttcg catcgagaag aagggcgtgc
     1141 gatatttgat gggtgggcgg acatttgaat gcctcgatgc ggtgattaat cgttaccgca
     1201 aggagcaaat tgtcgagggc cattcgctca atcatccggt tgtcaatggc atacagccag
     1261 agttcaatca gcaatatgtt gtggaaaagg ctgcggaaaa gatatatgcc acactgcgcg
     1321 agtgccgtga ccaaatcggt ctgaagaaga tcaagggaat caaacatcat gggcatttga
     1381 acaagaaatc ggacaaaacg acgaaatgga agcaactata tttcgctcta atcaacgatg
     1441 gctccgagac gcaactttgc ttctacgaca atccgaagaa gaccaagccg aagggtctga
     1501 tcgatttgtc atgtgcttac ctctatcaat gtcacgattc cctctgggag cgtccctatt
     1561 gctttcaaat tgtggaaagg gctctgccct gtttggccac tgtgacatat ctgtgtgctc
     1621 ctagtcagga aagctacgtg gagtggatca attcgctgaa ggcccaatgc gactcccagc
     1681 taagtcgggc ccagaagaag gtctcacggc tacgcgagct tcggtgtctc aatctgcatg
     1741 tgctagaagc tcatcgctta ccatttaaat tagtgccaca tccatactgc agtatttcac
     1801 tcaatcaagt caaagtgggt aaaacacgtg tcaaaattgc acccgaaccg gtttgggagg
     1861 aggaatttgt actggatgac gttcccccag atgttgtctc cctaaccatt acgttaatat
     1921 cgcgcggtaa acgcggcaaa gattcggaag tggccgagct aacgatcgat ttgtctagtc
     1981 tgaagaatgg ccaagagact gagggctggt accagctcac cggaatgacg ccgatgggcg
     2041 aatggggctc gctgcgtctg cgtatgcgtt acctcgacga tctgataatg ccctgcgagg
     2101 agtacagtcc actgcagcaa ttgctactcg aatcggagct gtatgcggtg aaggcgctgg
     2161 cggagctctg tcacaacgat cgagtgccat tggcgacggc tctgttgcga gtctttcggc
     2221 aggagaagcg cgagacggag ctaattcgaa tgctgtgcca ggcggaggtg acacgcgaaa
     2281 acgagacgac gacacttttc cggggcgcct ccttggccac cacactaatg gatttgtata
     2341 tgcgaaccga atgcagtgga ttcttgcagt cggcggtcag cgaaaccgtt cagcgcattt
     2401 tggagagcaa gcagtcggcg gaattaaatc caacgaaaat ggacgtcaac gatgatgcct
     2461 gcacgaatgc cgagtttctg ctgcaaatcc tcgatctggt cacccagtcg atatttactt
     2521 caccggacgc ctgtccccgg aatgtgcgct tcatttgcag ctgcctgcag aaggctgtga
     2581 tggccaagtg gccgacagag cggctggttc gcacccgagt cgtctccggg ttcatattct
     2641 tgcgcctcct atgcccagcc ctgctgaatc ctcgacaatt tggcctggtc agcgagacgc
     2701 ctccgatggc ggccactcgt tctttggtca tggtcgccaa gtgtcttcaa aatttggcca
     2761 acttgattga gtttggcggc aaggaacaat acatggaggt tgtcaatccg tttattttga
     2821 aaaacaagga acgcatgatt gtcttcttgg atcaactgtc ctccgtcaac gatccgaatc
     2881 aaccgcttgg aatgtttgtc gaacaaagta caaatctgaa ttcacaagac actgggcgcg
     2941 agctggctac cttacatcac atctgtgtat cgcattcgca agagcttcac gagctatcca
     3001 acatactttc aattaagaag ctggtcacag taacggacat gttgaccaag cataaactga
     3061 agtaccgcga gatgatcagc taaaataaag ataataaacg cgatgtcttc ttatctacac
     3121 aagtcccttc ataccttttt ataacaaata tttatatgtg tatactatta gaatacatga
     3181 taacaataag aactcataat aactggttga attgtattgg aatagtaaac agaagaatat
     3241 catttataaa aattatttat acgaaatgaa atattatatt taactgacag gtatatgcat
     3301 ttatttatta ttaaaaatta cttatataat acactagctt acacggagta ctctccgtat
     3361 agccgcaaaa aactcagaaa ttatacatgg ttttgctttt gatattgtgt tttaaattta
     3421 cagaaacaga aaccactttt atccaaaatc catacatttt tttcgagaca aataacgcat
     3481 aaaatcgaaa taaattaatg aatttataaa aaaaagagtg caaaagactt cctctgaaaa
     3541 aata