alpha-2-macroglobulin family protein [Escherichia coli].

LOCUS       WP_021502145            1464 aa            linear   BCT 25-DEC-2024
ACCESSION   WP_021502145
VERSION     WP_021502145.1
KEYWORDS    RefSeq.
SOURCE      Escherichia coli
  ORGANISM  Escherichia coli
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Escherichia.
REFERENCE   1  (residues 1 to 1464)
  AUTHORS   Arimura,Y. and Funabiki,H.
  TITLE     Structural Mechanics of the Alpha-2-Macroglobulin Transformation
  JOURNAL   J Mol Biol 434 (5), 167413 (2022)
   PUBMED   34942166
REFERENCE   2  (residues 1 to 1464)
  AUTHORS   Wong,S.G. and Dessen,A.
  TITLE     Structure of a bacterial alpha2-macroglobulin reveals mimicry of
            eukaryotic innate immunity
  JOURNAL   Nat Commun 5, 4917 (2014)
   PUBMED   25221932
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 1464)
  AUTHORS   Halaby,D.M., Poupon,A. and Mornon,J.
  TITLE     The immunoglobulin fold family: sequence analysis and 3D structure
            comparisons
  JOURNAL   Protein Eng 12 (7), 563-571 (1999)
   PUBMED   10436082
REFERENCE   4  (residues 1 to 1464)
  AUTHORS   Smith,D.K. and Xue,H.
  TITLE     Sequence profiles of immunoglobulin and immunoglobulin-like domains
  JOURNAL   J Mol Biol 274 (4), 530-545 (1997)
   PUBMED   9417933
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 11457182
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1464
                     /organism="Escherichia coli"
                     /db_xref="taxon:562"
     Protein         1..1464
                     /product="alpha-2-macroglobulin family protein"
                     /GO_function="GO:0004866 - endopeptidase inhibitor
                     activity [Evidence IEA]"
                     /GO_process="GO:0010951 - negative regulation of
                     endopeptidase activity [Evidence IEA]"
                     /calculated_mol_wt=162377
     Region          152..1456
                     /region_name="YfaS"
                     /note="Uncharacterized conserved protein YfaS,
                     alpha-2-macroglobulin family [General function prediction
                     only]; COG2373"
                     /db_xref="CDD:441940"
ORIGIN      
        1 mrleapgrdy rryqmeeygg vdvrlyripd pmaflrqqkn lhrivvqpqy lgdglnntlt
       61 wlwdnwygks rrvmqrtfss qsrqnvtqal pelqlgnaii kpsryvqnnq fsplkkyplv
      121 eqfryplwqa kpvepqqgvk legassnfis pqpgniyipl gqqepglylv eamvggyrat
      181 tvvfvsdtva lskvsgkell vwtagkkqge akpgseilwt dglgvmtrgv tddsgtlqlq
      241 hispersyil gkdaeggvfv senffyesei yntrlyiftd rplyragdrv dvkvmgrefh
      301 dplhsspivs apaklsvlda ngsllqtvdv tldarnggqg sfrlpenava ggyelrlayr
      361 nqvysssfrv anyikphfei glaldkkefk tgeavsgklq llypdgepvk narvqlslra
      421 qqlsmvgndl ryagrfpvsl egsetvsdas ghvalnlpaa dkpsrylltv sasdgaayrv
      481 tttkeilier glahyslsta aqysnsgesv vfryaaless kqvpvtyewl rledrtshsg
      541 dlpsggksft vnfdkpgnyn ltlrdkdgli laglshavsg kgsmshtgtv divadktlyq
      601 pgetakmlit fpepideall tlerdrveqq sllshpanwl tlqrlndtqy earvpvsnsf
      661 apnitfsvly trngqysfqn agikvavpql dirvktdkth yqpgelvnve ltsslkgkpv
      721 saqltvgvvd emiyalqpei apnigkffyp lgrnnvrtss slsfisydqa lssepvapga
      781 tnrserrvkm lerprreevd taawmpsltt dkqgkayftf lmpdsltrwr itargmngdg
      841 lvgqgraylr seknlymkws mptvyrvgdk psaglfifsq qdnepvalvt kfagaemrqt
      901 ltlhkganyi slaqniqqsg llsaelqqng qvqdsistkl sfvdnswpve qqknvmlggg
      961 dnalmlpeqa snirlqsset pqeifrnnld alvdepwggv intgsrlipl slawrsladh
     1021 qsaaandirq miqdnrlrlm qlagpgarft wwgedgngda fltawawyad wqasqalgvt
     1081 qqpeywqhml dsyaeqadnm pllhralvla waqemnlpck tllkgldeai arrgtktedf
     1141 seedtrdind slildtpesp ladavanvlt mtllkkaqlk stvmpqvqqy awdkavnsnq
     1201 plahtvvlln sggdatqaaa ilsgltaeqs tieralamnw lakymatmps vvlpapagaw
     1261 akhkltggge ywrwvgqgvp dilsfgdels pqnvqvrwre aaktaqqsni pvtverqlyr
     1321 lipgeeemsf tlqpvtsnei dsdalyldei tltseqdavl rygqvevplp pgadverttw
     1381 gisvnkpnag kqqgqlleka rnemgelaym vpvkeltgtv tfrhllrfsq kgqfvlppar
     1441 yvrsyapaqq svaagsewtg mqvk