MULTISPECIES: serine hydroxymethyltransferase [Citrobacter].

LOCUS       WP_019077397             417 aa            linear   BCT 29-MAR-2023
ACCESSION   WP_019077397
VERSION     WP_019077397.1
KEYWORDS    RefSeq.
SOURCE      Citrobacter
  ORGANISM  Citrobacter
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae.
REFERENCE   1  (residues 1 to 417)
  AUTHORS   Appaji Rao,N., Ambili,M., Jala,V.R., Subramanya,H.S. and
            Savithri,H.S.
  TITLE     Structure-function relationship in serine hydroxymethyltransferase
  JOURNAL   Biochim Biophys Acta 1647 (1-2), 24-29 (2003)
   PUBMED   12686103
REFERENCE   2  (residues 1 to 417)
  AUTHORS   Stover,P. and Schirch,V.
  TITLE     Serine hydroxymethyltransferase catalyzes the hydrolysis of
            5,10-methenyltetrahydrofolate to 5-formyltetrahydrofolate
  JOURNAL   J Biol Chem 265 (24), 14227-14233 (1990)
   PUBMED   2201683
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 10011056
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..417
                     /organism="Citrobacter"
                     /db_xref="taxon:544"
     gene            1..417
                     /gene="glyA"
     Protein         1..417
                     /product="serine hydroxymethyltransferase"
                     /EC_number="2.1.2.1"
                     /GO_function="GO:0004372 - glycine
                     hydroxymethyltransferase activity [Evidence IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /GO_function="GO:0070905 - serine binding [Evidence IEA]"
                     /GO_process="GO:0019264 - glycine biosynthetic process
                     from serine [Evidence IEA]"
                     /calculated_mol_wt=45381
     Region          6..417
                     /region_name="glyA"
                     /note="serine hydroxymethyltransferase; Reviewed;
                     PRK00011"
                     /db_xref="CDD:234571"
     Site            order(12,14,21..22,31,36,54,72..73,81,96,103,138..139,265,
                     283)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:99733"
     Site            order(35,55,65,98..99,126,175,200,203,228..229,235,363)
                     /site_type="other"
                     /note="glycine-pyridoxal phosphate binding site [chemical
                     binding]"
                     /db_xref="CDD:99733"
     Site            order(35,126,229,363)
                     /site_type="active"
                     /db_xref="CDD:99733"
     Site            order(57,64,121,125,127,257,347)
                     /site_type="other"
                     /note="folate binding site [chemical binding]"
                     /db_xref="CDD:99733"
ORIGIN      
        1 mlkremniad ydaelwqame qekvrqeehi eliasenyts prvmqaqgsq ltnkyaegyp
       61 gkryyggcey vdiveqlaid rakelfgady anvqphsgsq anfavytall qpgdtvlgmn
      121 laqgghlthg spvnfsgkly niipygides gkidyedmak qakehkpkmi iggfsaysgv
      181 vdwakmreia dsigaylfvd mahvagliaa gvypnpvpha hvvtttthkt lagprgglil
      241 akggdeelyk klnsavfpsa qggplmhvia akavalkeam epefkvyqqq vaknakamve
      301 vflnrgykvv sggtenhlfl ldlvdknltg keadaalgra nitvnknsvp ndpkspfvts
      361 girigspavt rrgfkeaevk elagwmcdvl dnindesvie rvkgkvldic arfpvya