MULTISPECIES: aldolase catalytic domain-containing protein

LOCUS       WP_017634974             536 aa            linear   BCT 26-JUL-2024
            [Vibrio].
ACCESSION   WP_017634974
VERSION     WP_017634974.1
KEYWORDS    RefSeq.
SOURCE      Vibrio
  ORGANISM  Vibrio
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Vibrionales; Vibrionaceae.
REFERENCE   1  (residues 1 to 536)
  AUTHORS   Kumar,G., Johnson,J.L. and Frantom,P.A.
  TITLE     Improving Functional Annotation in the DRE-TIM Metallolyase
            Superfamily through Identification of Active Site Fingerprints
  JOURNAL   Biochemistry 55 (12), 1863-1872 (2016)
   PUBMED   26935545
REFERENCE   2  (residues 1 to 536)
  AUTHORS   Nagano,N., Orengo,C.A. and Thornton,J.M.
  TITLE     One fold with many functions: the evolutionary relationships
            between TIM barrel families based on their sequences, structures
            and functions
  JOURNAL   J Mol Biol 321 (5), 741-765 (2002)
   PUBMED   12206759
REFERENCE   3  (residues 1 to 536)
  AUTHORS   Wierenga,R.K.
  TITLE     The TIM-barrel fold: a versatile framework for efficient enzymes
  JOURNAL   FEBS Lett 492 (3), 193-198 (2001)
   PUBMED   11257493
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 10168244
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..536
                     /organism="Vibrio"
                     /db_xref="taxon:662"
     Protein         1..536
                     /product="aldolase catalytic domain-containing protein"
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /calculated_mol_wt=59127
     Region          4..273
                     /region_name="DRE_TIM_HOA_like"
                     /note="4-hydroxy-2-oxovalerate aldolase-like, N-terminal
                     catalytic TIM barrel domain; cd07944"
                     /db_xref="CDD:163682"
     Site            order(10..11,14,41,78,80,141,169,198,200)
                     /site_type="active"
                     /db_xref="CDD:163682"
     Site            order(10..11,41)
                     /site_type="active"
                     /note="catalytic residues [active]"
                     /db_xref="CDD:163682"
     Site            order(11,169,198,200)
                     /site_type="metal-binding"
                     /note="metal binding site [ion binding]"
                     /db_xref="CDD:163682"
ORIGIN      
        1 mqkildctlr dggyynhwdf spevvdaylt avakakidyv elglrnypks vysgpfaytt
       61 eeflntlhlp kgptygvmvd aktlldagkp vvaaindlfv paqeskvdlv riaahfneae
      121 qcesmikafk emgyivglnl mqaggkpsvv iaekvqavak anpdviyfad slgnmdsaev
      181 triaeivkqn wdgdigihth nnmgqamsnt mtarsngvtw ldvtvtgmgr gagnaqtenl
      241 laeldgldky lptaiyelvi rhfepmqrry gwgssllyyl gakndihpty iqnmlsnpny
      301 gteeivgaie hlkklegtts yngdvleeal tvgkisqpte sqsdlsgifs gkeillvtnt
      361 pnaathrvai etyiktrkpi vigintkhei ntelfdyfav shnskylses shysevakpv
      421 flpknrfded elskfsnism idysstiekd tltahknyct lpydntaaya lciafigqaq
      481 kislvgfdgy dvtdrrqmem neifsmvsqq fgstsiqalt pttypvkags iyapai