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LOCUS WP_017041491 419 aa linear BCT 21-JAN-2025 F10]. ACCESSION WP_017041491 VERSION WP_017041491.1 KEYWORDS RefSeq. SOURCE Vibrio genomosp. F10 ORGANISM Vibrio genomosp. F10 Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Vibrionales; Vibrionaceae; Vibrio. REFERENCE 1 (residues 1 to 419) AUTHORS Wen,Y., Behiels,E., Felix,J., Elegheert,J., Vergauwen,B., Devreese,B. and Savvides,S.N. TITLE The bacterial antitoxin HipB establishes a ternary complex with operator DNA and phosphorylated toxin HipA to regulate bacterial persistence JOURNAL Nucleic Acids Res 42 (15), 10134-10147 (2014) PUBMED 25056321 REFERENCE 2 (residues 1 to 419) AUTHORS Germain,E., Castro-Roa,D., Zenkin,N. and Gerdes,K. TITLE Molecular mechanism of bacterial persistence by HipA JOURNAL Mol Cell 52 (2), 248-254 (2013) PUBMED 24095282 REFERENCE 3 (residues 1 to 419) AUTHORS Kaspy,I., Rotem,E., Weiss,N., Ronin,I., Balaban,N.Q. and Glaser,G. TITLE HipA-mediated antibiotic persistence via phosphorylation of the glutamyl-tRNA-synthetase JOURNAL Nat Commun 4, 3001 (2013) PUBMED 24343429 REFERENCE 4 (residues 1 to 419) AUTHORS Schumacher,M.A., Piro,K.M., Xu,W., Hansen,S., Lewis,K. and Brennan,R.G. TITLE Molecular mechanisms of HipA-mediated multidrug tolerance and its neutralization by HipB JOURNAL Science 323 (5912), 396-401 (2009) PUBMED 19150849 REFERENCE 5 (residues 1 to 419) AUTHORS Jayaraman,R. TITLE Bacterial persistence: some new insights into an old phenomenon JOURNAL J Biosci 33 (5), 795-805 (2008) PUBMED 19179767 REFERENCE 6 (residues 1 to 419) AUTHORS Black,D.S., Kelly,A.J., Mardis,M.J. and Moyed,H.S. TITLE Structure and organization of hip, an operon that affects lethality due to inhibition of peptidoglycan or DNA synthesis JOURNAL J Bacteriol 173 (18), 5732-5739 (1991) PUBMED 1715862 COMMENT REFSEQ: This record represents a single, non-redundant, protein sequence which may be annotated on many different RefSeq genomes from the same, or different, species. ##Evidence-For-Name-Assignment-START## Evidence Category :: Conserved Domain (CDD) Evidence Accession :: Domain architecture ID 11466423 Evidence Source :: NCBI SPARCLE ##Evidence-For-Name-Assignment-END## COMPLETENESS: full length. FEATURES Location/Qualifiers source 1..419 /organism="Vibrio genomosp. F10" /db_xref="taxon:723171" Protein 1..419 /product="type II toxin-antitoxin system HipA family toxin" /EC_number="2.7.11.1" /GO_component="GO:0110001 - toxin-antitoxin complex [Evidence IEA]" /GO_function="GO:0004674 - protein serine/threonine kinase activity [Evidence IEA]" /GO_process="GO:0016310 - phosphorylation [Evidence IEA]" /calculated_mol_wt=47630 Region 11..408 /region_name="HipA" /note="Serine/threonine protein kinase HipA, toxin component of the HipAB toxin-antitoxin module [Signal transduction mechanisms]; COG3550" /db_xref="CDD:442771" ORIGIN 1 mtrqvekveg lniqlhgidv avithyaggk niltfnpefv vmpvekrpvf tlrqlrdpgy 61 lskpqirtdk iptvlsnllp egalreltak alqchvnnef silaylgsnl pgaliakpik 121 agdvpdwale qrlstepqqi nvrhadtkfs lagvqmkfss shldgryhid qeisedmwii 181 ktpstvhkgv pvneytcmkl aeaagaeipe irlieleele glpciklpne qyaygikrfd 241 rsdqgrihte dfaqvfglyp sdkyqrvnye qlgnvlyqss serlkdiqqm arrllinill 301 gngdahlknw tliysdaysp rlsplydvvf tspyiendsl alnmvgtkqw feitmkhfee 361 waekagvpwv avkphlidvm slarknwpnl lqelpmeveq kdalkkhwgk lsddfrisl