PAS domain-containing hybrid sensor histidine kinase/response

LOCUS       WP_017007874            1150 aa            linear   BCT 26-FEB-2025
            regulator [Enterovibrio norvegicus].
ACCESSION   WP_017007874
VERSION     WP_017007874.1
KEYWORDS    RefSeq.
SOURCE      Enterovibrio norvegicus
  ORGANISM  Enterovibrio norvegicus
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Vibrionales; Vibrionaceae; Enterovibrio.
REFERENCE   1  (residues 1 to 1150)
  AUTHORS   Stuffle,E.C., Johnson,M.S. and Watts,K.J.
  TITLE     PAS domains in bacterial signal transduction
  JOURNAL   Curr Opin Microbiol 61, 8-15 (2021)
   PUBMED   33647528
REFERENCE   2  (residues 1 to 1150)
  AUTHORS   Gao,R., Bouillet,S. and Stock,A.M.
  TITLE     Structural Basis of Response Regulator Function
  JOURNAL   Annu Rev Microbiol 73, 175-197 (2019)
   PUBMED   31100988
REFERENCE   3  (residues 1 to 1150)
  AUTHORS   Ortet,P., Whitworth,D.E., Santaella,C., Achouak,W. and Barakat,M.
  TITLE     P2CS: updates of the prokaryotic two-component systems database
  JOURNAL   Nucleic Acids Res 43 (Database issue), D536-D541 (2015)
   PUBMED   25324303
REFERENCE   4  (residues 1 to 1150)
  AUTHORS   Attwood,P.V.
  TITLE     Histidine kinases from bacteria to humans
  JOURNAL   Biochem Soc Trans 41 (4), 1023-1028 (2013)
   PUBMED   23863173
REFERENCE   5  (residues 1 to 1150)
  AUTHORS   Galperin,M.Y.
  TITLE     Diversity of structure and function of response regulator output
            domains
  JOURNAL   Curr Opin Microbiol 13 (2), 150-159 (2010)
   PUBMED   20226724
REFERENCE   6  (residues 1 to 1150)
  AUTHORS   Galperin,M.Y.
  TITLE     Structural classification of bacterial response regulators:
            diversity of output domains and domain combinations
  JOURNAL   J Bacteriol 188 (12), 4169-4182 (2006)
   PUBMED   16740923
REFERENCE   7  (residues 1 to 1150)
  AUTHORS   Hefti,M.H., Francoijs,K.J., de Vries,S.C., Dixon,R. and Vervoort,J.
  TITLE     The PAS fold. A redefinition of the PAS domain based upon
            structural prediction
  JOURNAL   Eur J Biochem 271 (6), 1198-1208 (2004)
   PUBMED   15009198
REFERENCE   8  (residues 1 to 1150)
  AUTHORS   Dutta,R. and Inouye,M.
  TITLE     GHKL, an emergent ATPase/kinase superfamily
  JOURNAL   Trends Biochem Sci 25 (1), 24-28 (2000)
   PUBMED   10637609
REFERENCE   9  (residues 1 to 1150)
  AUTHORS   Stock,A.M., Robinson,V.L. and Goudreau,P.N.
  TITLE     Two-component signal transduction
  JOURNAL   Annu Rev Biochem 69, 183-215 (2000)
   PUBMED   10966457
REFERENCE   10 (residues 1 to 1150)
  AUTHORS   Stock,J.
  TITLE     Signal transduction: Gyrating protein kinases
  JOURNAL   Curr Biol 9 (10), R364-R367 (1999)
   PUBMED   10339418
REFERENCE   11 (residues 1 to 1150)
  AUTHORS   Ponting,C.P. and Aravind,L.
  TITLE     PAS: a multifunctional domain family comes to light
  JOURNAL   Curr Biol 7 (11), R674-R677 (1997)
   PUBMED   9382818
REFERENCE   12 (residues 1 to 1150)
  AUTHORS   Alex,L.A. and Simon,M.I.
  TITLE     Protein histidine kinases and signal transduction in prokaryotes
            and eukaryotes
  JOURNAL   Trends Genet 10 (4), 133-138 (1994)
   PUBMED   8029829
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 11586208
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1150
                     /organism="Enterovibrio norvegicus"
                     /db_xref="taxon:188144"
     Protein         1..1150
                     /product="PAS domain-containing hybrid sensor histidine
                     kinase/response regulator"
                     /EC_number="2.7.13.3"
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /calculated_mol_wt=126299
     Region          6..501
                     /region_name="SLC5sbd"
                     /note="Solute carrier 5 family, sodium/glucose
                     transporters and related proteins; solute-binding domain;
                     cd10322"
                     /db_xref="CDD:271357"
     Site            order(45,48,330,333..334)
                     /site_type="other"
                     /note="Na binding site [ion binding]"
                     /db_xref="CDD:271357"
     Region          635..749
                     /region_name="PAS_7"
                     /note="PAS fold; pfam12860"
                     /db_xref="CDD:432837"
     Region          <758..1002
                     /region_name="BaeS"
                     /note="Signal transduction histidine kinase [Signal
                     transduction mechanisms]; COG0642"
                     /db_xref="CDD:440407"
     Region          1027..1150
                     /region_name="CheY"
                     /note="CheY-like REC (receiver) domain, includes
                     chemotaxis protein CheY and sporulation regulator Spo0F
                     [Signal transduction mechanisms]; COG0784"
                     /db_xref="CDD:440547"
ORIGIN      
        1 msagwivvpv alaylgvlfl iawygdnrpr wlrgwrpwiy slsiavycts wtffgtvgqa
       61 ssqpwsflpi ylapilvfti gwrflariil iakrehitsi adfiaarygk sqglavlvtv
      121 iavvgilpyi alqlrgitmg ldviapnigk dagldqgqit wlvcvslamf tvlfgtrhid
      181 stehhrgmmm avafesivkl vaflvvglfa vsmlletdid lpslaetgvv gppnwgallv
      241 htlltmaaii clprqfhtmv venaraqdlh tarwvfplyl llmgvfvlpl ayagqvflpq
      301 fsadthviql plstgndgia llaflggasa asgmvivsti alaimvsndl vlpqllrrmr
      361 isnrnftqfs glllnvrral ifflliaawg fyqlilevps lsaigflsfa aiaqfapplv
      421 agiywrqank kgvyaglvsg fivwlmtlmt qtgmlagtae tnlvlwllep palpffrdls
      481 avdwgmvlsl mvntacfvgv smatrpslse rlqaasfvgt plpegddssl yqsrvtvael
      541 emlaarfvgr trmrqtfrtf geqrgetllp qqqasaalir htervlagvf gassaklvlt
      601 salqgrnmql eeiativdea selfdfsrgl lqgaiehisq gisvvdkqlr lvawnqryve
      661 lfkfppdliq vgrpiadvvr ynaerglcgp geieahvakr vsylrqgsph tssrvhpdgr
      721 vievqgnpmp gggfvmsftd itafrdaeea lkqsnetlea rviartqele slnrrlisat
      781 nkaehasqsk srllaavshd lmqplnaarl fasslnemaq dqdvqnmsgh iesalgaaed
      841 ligdlldisr lesgkmkaqi tdfdldevfs tlaaefgmia neqgvefkvl ptglrirsdr
      901 rllrrvlqnf ltnafrynpd grvllgvrrr gdecsievwd ngpgipedrq qdifdeftri
      961 drkgaelglg lglaiargis rilnqsldlr swpgkgtvfs itahvttvmp qvcdtgvead
     1021 aapknsmqla gvrvlcvdne rdilagmesl lsrwgcevkv aedldevvac fqhdwlpdfi
     1081 lsdyhlapsl tgldvlqecr rllgdafyga iitadrtqet qqcirakgfg yiakpvkplk
     1141 lrallqqgvs