IMP dehydrogenase [Klebsiella pneumoniae].

LOCUS       WP_014343371             358 aa            linear   BCT 01-JAN-2025
ACCESSION   WP_014343371
VERSION     WP_014343371.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella pneumoniae
  ORGANISM  Klebsiella pneumoniae
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group;
            Klebsiella; Klebsiella pneumoniae complex.
REFERENCE   1  (residues 1 to 358)
  AUTHORS   Hedstrom,L. and Gan,L.
  TITLE     IMP dehydrogenase: structural schizophrenia and an unusual base
  JOURNAL   Curr Opin Chem Biol 10 (5), 520-525 (2006)
   PUBMED   16919497
REFERENCE   2  (residues 1 to 358)
  AUTHORS   Metz,S.A. and Kowluru,A.
  TITLE     Inosine monophosphate dehydrogenase: A molecular switch integrating
            pleiotropic GTP-dependent beta-cell functions
  JOURNAL   Proc Assoc Am Physicians 111 (4), 335-346 (1999)
   PUBMED   10417742
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 11996318
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..358
                     /organism="Klebsiella pneumoniae"
                     /db_xref="taxon:573"
     gene            1..358
                     /gene="guaB"
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
     Protein         1..358
                     /product="IMP dehydrogenase"
                     /EC_number="1.1.1.205"
                     /GO_function="GO:0000166 - nucleotide binding [Evidence
                     IEA]"
                     /GO_function="GO:0003938 - IMP dehydrogenase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0006177 - GMP biosynthetic process
                     [Evidence IEA]"
                     /calculated_mol_wt=39088
     Region          8..>302
                     /region_name="IMPDH"
                     /note="IMP dehydrogenase / GMP reductase domain;
                     pfam00478"
                     /db_xref="CDD:459826"
ORIGIN      
        1 mlriakealt fddvllvpah stvlpntadl stqltktirl nipmlsaamd tvtearlaia
       61 laqeggigfi hknmsierqa eevrrvkkhe sgvvtdpqtv lptttlrevk elterngfag
      121 ypvvteenel vgiitgrdvr fvtdlnqpvs vymtpkerlv tvregesrev vfakmhekrv
      181 ekalvvdesf hlrgmitvkd fqkaerkpna ckdeqgrlrv gaavgagagn eervdalvaa
      241 gvdvllidss hghsegvlqr iretrakypd lqiiggnvat gagaralaea gcsavkvgig
      301 pglhlyypvs spawvcrrsl lfptrwkrwk gpvfrlslta vsvspaispk rsppvrrr