MULTISPECIES: serine protease inhibitor ecotin [Klebsiella].

LOCUS       WP_014343358             163 aa            linear   BCT 13-MAY-2021
ACCESSION   WP_014343358
VERSION     WP_014343358.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella
  ORGANISM  Klebsiella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group.
REFERENCE   1  (residues 1 to 163)
  AUTHORS   Ireland,P.M., Marshall,L., Norville,I. and Sarkar-Tyson,M.
  TITLE     The serine protease inhibitor Ecotin is required for full virulence
            of Burkholderia pseudomallei
  JOURNAL   Microb. Pathog. 67-68, 55-58 (2014)
   PUBMED   24462575
REFERENCE   2  (residues 1 to 163)
  AUTHORS   McGrath,M.E., Gillmor,S.A. and Fletterick,R.J.
  TITLE     Ecotin: lessons on survival in a protease-filled world
  JOURNAL   Protein Sci. 4 (2), 141-148 (1995)
   PUBMED   7757004
REFERENCE   3  (residues 1 to 163)
  AUTHORS   McGrath,M.E., Hines,W.M., Sakanari,J.A., Fletterick,R.J. and
            Craik,C.S.
  TITLE     The sequence and reactive site of ecotin. A general inhibitor of
            pancreatic serine proteases from Escherichia coli
  JOURNAL   J. Biol. Chem. 266 (10), 6620-6625 (1991)
   PUBMED   2007606
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: NF002987.0
            Evidence Source    :: NCBI Protein Cluster (PRK)
            Source Identifier  :: PRK03719
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..163
                     /organism="Klebsiella"
                     /db_xref="taxon:570"
     gene            1..163
                     /gene="eco"
     Protein         1..163
                     /product="serine protease inhibitor ecotin"
                     /GO_function="GO:0004867 - serine-type endopeptidase
                     inhibitor activity [Evidence IEA]"
                     /calculated_mol_wt=17893
     Region          1..163
                     /region_name="Eco"
                     /note="Serine protease inhibitor ecotin [Posttranslational
                     modification, protein turnover, chaperones]; COG4574"
                     /db_xref="CDD:443631"
     Site            order(87..91,129..134)
                     /site_type="active"
                     /note="secondary substrate binding site [active]"
                     /db_xref="CDD:153074"
     Site            103..106
                     /site_type="active"
                     /note="primary substrate binding site [active]"
                     /db_xref="CDD:153074"
     Site            105..106
                     /site_type="inhibition"
                     /note="inhibition loop"
                     /db_xref="CDD:153074"
     Site            151..161
                     /site_type="other"
                     /note="dimerization interface [polypeptide binding]"
                     /db_xref="CDD:153074"
ORIGIN      
        1 mkkittlavs lltaacmsag alaadqplek vapfpkaekg mkrqviqlpq qqdesalkve
       61 lmigqtlevd cnhhrlggel esktlegwgy dyyvfeklsg pvstmmacpd gkkekkfvta
      121 glgddamlry nsklpivvyt psnvdvkyri wradetisna vvr