MFS transporter [Klebsiella pneumoniae].

LOCUS       WP_014343253             503 aa            linear   BCT 01-JAN-2025
ACCESSION   WP_014343253
VERSION     WP_014343253.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella pneumoniae
  ORGANISM  Klebsiella pneumoniae
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group;
            Klebsiella; Klebsiella pneumoniae complex.
REFERENCE   1  (residues 1 to 503)
  AUTHORS   Quistgaard,E.M., Low,C., Guettou,F. and Nordlund,P.
  TITLE     Understanding transport by the major facilitator superfamily (MFS):
            structures pave the way
  JOURNAL   Nat Rev Mol Cell Biol 17 (2), 123-132 (2016)
   PUBMED   26758938
REFERENCE   2  (residues 1 to 503)
  AUTHORS   Zhang,X.C., Zhao,Y., Heng,J. and Jiang,D.
  TITLE     Energy coupling mechanisms of MFS transporters
  JOURNAL   Protein Sci 24 (10), 1560-1579 (2015)
   PUBMED   26234418
REFERENCE   3  (residues 1 to 503)
  AUTHORS   Yan,N.
  TITLE     Structural Biology of the Major Facilitator Superfamily
            Transporters
  JOURNAL   Annu Rev Biophys 44, 257-283 (2015)
   PUBMED   26098515
REFERENCE   4  (residues 1 to 503)
  AUTHORS   Yan,N.
  TITLE     Structural advances for the major facilitator superfamily (MFS)
            transporters
  JOURNAL   Trends Biochem Sci 38 (3), 151-159 (2013)
   PUBMED   23403214
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 13023745
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Klebsiella pneumoniae"
                     /db_xref="taxon:573"
     Protein         1..503
                     /product="MFS transporter"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport
                     [Evidence IEA]"
                     /calculated_mol_wt=55631
     Region          6..440
                     /region_name="MFS_MelB_like"
                     /note="Salmonella enterica Na+/melibiose symporter MelB
                     and similar transporters of the Major Facilitator
                     Superfamily; cd17332"
                     /db_xref="CDD:340890"
     Site            order(15..16,19..20,23,56,116..117,119..121,124,145,
                     148..149,152,243,246..247,250..252,255,283,287,341..342,
                     346,350,373,376..377,380..381,384)
                     /site_type="other"
                     /note="putative chemical substrate binding pocket
                     [chemical binding]"
                     /db_xref="CDD:340890"
ORIGIN      
        1 mlrhqlaygg gnllgsgala isgawllyfy ttfcgltlie asfifsvasi idaisnplmg
       61 yltdnfgktr lgkrfgrrrf flligiplmm fypllwvegl sfwyylstyv vfeiiytsim
      121 vpyetlatem tddfslrskl tgykaifgkl anflaafipg qfillygkds atpffltglt
      181 ygailivais clwlcswere rgeevetsak kgllstllsl akdmrstfyl rvfrkhlgmy
      241 lcgfgaewlf asiftyfvif vlqhdpamva glnslnsilq listalfigl cvkkgfskpy
      301 ilalgivifa vllytslwff hlpsglatvl mfgitvlfgl gtggvyyipw tvytfladvd
      361 eiytgrrreg iyagamtfsg kilrsivvfs mgailsfygf qskahsqpes avtaiavvfc
      421 vgvialalaa ivfskqmkld rkahlvvlqe varikaggki sdiapdvrvi vedlvghrye
      481 ecwgnsklfk daasapaqtv vsh