MULTISPECIES: MFS transporter [Klebsiella].

LOCUS       WP_014343130             384 aa            linear   BCT 22-JUL-2024
ACCESSION   WP_014343130
VERSION     WP_014343130.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella
  ORGANISM  Klebsiella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group.
REFERENCE   1  (residues 1 to 384)
  AUTHORS   Quistgaard,E.M., Low,C., Guettou,F. and Nordlund,P.
  TITLE     Understanding transport by the major facilitator superfamily (MFS):
            structures pave the way
  JOURNAL   Nat Rev Mol Cell Biol 17 (2), 123-132 (2016)
   PUBMED   26758938
REFERENCE   2  (residues 1 to 384)
  AUTHORS   Yan,N.
  TITLE     Structural Biology of the Major Facilitator Superfamily
            Transporters
  JOURNAL   Annu Rev Biophys 44, 257-283 (2015)
   PUBMED   26098515
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 13023516
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..384
                     /organism="Klebsiella"
                     /db_xref="taxon:570"
     Protein         1..384
                     /product="MFS transporter"
                     /GO_component="GO:0005886 - plasma membrane [Evidence
                     IEA]"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport
                     [Evidence IEA]"
                     /calculated_mol_wt=40191
     Region          9..378
                     /region_name="MFS_NepI_like"
                     /note="Purine ribonucleoside efflux pump NepI and similar
                     transporters of the Major Facilitator Superfamily;
                     cd17324"
                     /db_xref="CDD:340882"
     Site            order(17..18,21..22,25,57,107..108,110..112,115,134,
                     137..138,141,217,220..221,224..226,229,255,259,309..310,
                     314,318,333,336..337,340..341,344)
                     /site_type="other"
                     /note="putative chemical substrate binding pocket
                     [chemical binding]"
                     /db_xref="CDD:340882"
ORIGIN      
        1 mlttgitalf sltcalavan vysaqpllds mavslkvspg migsvitatq agyaigllfl
       61 vplgdwlnrk yvvmsqllls vaalvaagls pnivtllgam livglmavvv qvlvawvail
      121 atpqkrgqav gtltsgivsg illsrfisga iadiagwrav yltaaclmlm iagivwkimp
      181 sppqqpqpqk ptylsllksv fqlyltepql rkrgilalfi faafsmlwtt mvmpltalsl
      241 shtqtgmfgl agfagmlaaa ragkwadqgw aqrttglala lltiswlpig yaetsllwli
      301 agvialdfav qavhvssqsl iiaarpaaas rlvgaymcfy slgsaagaiv atqlyshwgw
      361 qavclagaav sacafliwsg srqs