5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase

LOCUS       WP_014342870             488 aa            linear   BCT 19-JUN-2019
            [Klebsiella pneumoniae].
ACCESSION   WP_014342870
VERSION     WP_014342870.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella pneumoniae
  ORGANISM  Klebsiella pneumoniae
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group;
            Klebsiella; Klebsiella pneumoniae complex.
REFERENCE   1  (residues 1 to 488)
  AUTHORS   Nordlund,I. and Shingler,V.
  TITLE     Nucleotide sequences of the meta-cleavage pathway enzymes
            2-hydroxymuconic semialdehyde dehydrogenase and 2-hydroxymuconic
            semialdehyde hydrolase from Pseudomonas CF600
  JOURNAL   Biochim. Biophys. Acta 1049 (2), 227-230 (1990)
   PUBMED   2194577
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: TIGR02299.1
            Evidence Source    :: JCVI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..488
                     /organism="Klebsiella pneumoniae"
                     /db_xref="taxon:573"
     gene            1..488
                     /gene="hpaE"
     Protein         1..488
                     /product="5-carboxymethyl-2-hydroxymuconate semialdehyde
                     dehydrogenase"
                     /GO_function="GO:0018480 -
                     5-carboxymethyl-2-hydroxymuconic-semialdehyde
                     dehydrogenase activity [Evidence IEA]"
                     /GO_process="GO:1901023 - 4-hydroxyphenylacetate catabolic
                     process [Evidence IEA]"
                     /calculated_mol_wt=52880
     Region          21..476
                     /region_name="ALDH_F8_HMSADH"
                     /note="Human aldehyde dehydrogenase family 8 member
                     A1-like; cd07093"
                     /db_xref="CDD:143412"
     Site            order(145..147,153,171,173..174,204,208..209,223..225,228,
                     231,244..245,278,382,384,448)
                     /site_type="other"
                     /note="NAD binding site [chemical binding]"
                     /db_xref="CDD:143412"
     Site            order(148,244,275,278)
                     /site_type="active"
                     /note="catalytic residues [active]"
                     /db_xref="CDD:143412"
ORIGIN      
        1 mkkinhwing knvagadyfh ttnpatgevl aevasggeae inqavaaake afpkwanlpm
       61 kerarlmrrl gdlidqnvpe iaametadtg lpihqtknvl iprashnfef faevcqqmng
      121 ktypvddkml nytlvqpvgv calvspwnvp fmtatwkvap clalgntavl kmselsplta
      181 drlgelalea gipagvlnvv qgygatagda lvrhhdvrav sftggtatgr nimknaglkk
      241 ysmelggksp vlifedadie raldaalfti fsingercta gsrifiqqsi ypefvkrfae
      301 ranrlrvgdp tdpntqvgal itqqhwekvs gyirlgieeg atllaggadk psdlpahlka
      361 gnflrptvla dvdnrmrvaq eeifgpvacl lpfkdeaegl rlandveygl asyiwtqdvs
      421 kvlrlargie agmvfvntqn vrdlrqpfgg vkasgtgreg geysfevfae mknvcismgd
      481 hpipkwgv