methionine synthase [Klebsiella pneumoniae].

LOCUS       WP_014342858            1227 aa            linear   BCT 27-MAR-2023
ACCESSION   WP_014342858
VERSION     WP_014342858.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella pneumoniae
  ORGANISM  Klebsiella pneumoniae
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group;
            Klebsiella; Klebsiella pneumoniae complex.
REFERENCE   1  (residues 1 to 1227)
  AUTHORS   Dixon,M.M., Huang,S., Matthews,R.G. and Ludwig,M.
  TITLE     The structure of the C-terminal domain of methionine synthase:
            presenting S-adenosylmethionine for reductive methylation of B12
  JOURNAL   Structure 4 (11), 1263-1275 (1996)
   PUBMED   8939751
REFERENCE   2  (residues 1 to 1227)
  AUTHORS   Drummond,J.T., Loo,R.R. and Matthews,R.G.
  TITLE     Electrospray mass spectrometric analysis of the domains of a large
            enzyme: observation of the occupied cobalamin-binding domain and
            redefinition of the carboxyl terminus of methionine synthase
  JOURNAL   Biochemistry 32 (36), 9282-9289 (1993)
   PUBMED   8369296
REFERENCE   3  (residues 1 to 1227)
  AUTHORS   Luschinsky,C.L., Drummond,J.T., Matthews,R.G. and Ludwig,M.L.
  TITLE     Crystallization and preliminary X-ray diffraction studies of the
            cobalamin-binding domain of methionine synthase from Escherichia
            coli
  JOURNAL   J Mol Biol 225 (2), 557-560 (1992)
   PUBMED   1593636
REFERENCE   4  (residues 1 to 1227)
  AUTHORS   Banerjee,R.V., Johnston,N.L., Sobeski,J.K., Datta,P. and
            Matthews,R.G.
  TITLE     Cloning and sequence analysis of the Escherichia coli metH gene
            encoding cobalamin-dependent methionine synthase and isolation of a
            tryptic fragment containing the cobalamin-binding domain
  JOURNAL   J Biol Chem 264 (23), 13888-13895 (1989)
   PUBMED   2668277
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: NF007024.0
            Evidence Source    :: NCBI Protein Cluster (PRK)
            Source Identifier  :: PRK09490
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1227
                     /organism="Klebsiella pneumoniae"
                     /db_xref="taxon:573"
     gene            1..1227
                     /gene="metH"
     Protein         1..1227
                     /product="methionine synthase"
                     /EC_number="2.1.1.13"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0008705 - methionine synthase activity
                     [Evidence IEA]"
                     /GO_function="GO:0031419 - cobalamin binding [Evidence
                     IEA]"
                     /GO_process="GO:0009086 - methionine biosynthetic process
                     [Evidence IEA]"
                     /calculated_mol_wt=135594
     Region          1..1223
                     /region_name="metH"
                     /note="B12-dependent methionine synthase; Provisional;
                     PRK09490"
                     /db_xref="CDD:236539"
ORIGIN      
        1 msskveqlhq qlkerilvld ggmgtmiqgy rlseqdfrge rfadwpcdlk gnndllvlsk
       61 pevireihga yfeagadiie tntfnsttia madyqmesls aeinfaaakl arasadawta
      121 rtpekpryva gvlgptnrta sispdvndpa frnitfdqlv aayrestral veggvdlili
      181 etvfdtlnak aaiyavkeel ealgvdlplm isgtitdasg rtlsgqttea fynslrhaea
      241 lsfglncalg pdelrqyvqe lsriaecyvt ahpnaglpna fgeydldadt matqirewae
      301 agflnivggc cgttpehiaa msravaglpp rqlpeiavac rlagleplni gddslfvnvg
      361 ertnvtgsak fkrlikeeky sealdvarqq vesgaqiidi nmdegmldae aamvrflnli
      421 agepdiarvp imidsskwev iekglkciqg kgivnsismk egvesfihha klvrrygaav
      481 vvmafdevgq adtrerkiei crraykilte evgfppedii fdpnifavat gieehnnyaq
      541 dfigacedik relphalisg gvsnvsfsfr gndpvreaih avflyyairn gmdmgivnag
      601 qlaiyddlpg elrdavedvi lnrrddster llelaekyrg skaddganaq qaewrtwevk
      661 krleyslvkg itefieqdte earqqaarpi eviegplmdg mnvvgdlfge gkmflpqvvk
      721 sarvmkqava ylepfieask eqgssngkmv iatvkgdvhd igknivgvvl qcnnyeiidl
      781 gvmvpadkil ktakevnadl iglsglitps ldemvnvake merqgftipl liggattska
      841 htavkieqny sgptvyvqna srtvgvvsal lsdtqrdefv artrkeyetv riqhgrkkpr
      901 tppvtlaaar endlafdwes ytppvahrlg vqtveasiet lrnyidwtpf fmtwslagky
      961 priledevvg eeaqrlfkda nelldklsae ktlnprgvvg lfpanrvgdd ieiyrdetrt
     1021 hvltvshhlr qqtekvgfan ycladfvapk lsgkadyiga favtggleed aladayeaqh
     1081 ddynkimika iadrlaeafa eylhekvrkv ywgyaanenl sneelireny qgirpapgyp
     1141 acpehtekgt iwqlldveah tgmkltesfa mwpgasvsgw yfshpdskyf avaqiqrdqv
     1201 edyalrkgmt paeverwlap nlgydad