thioredoxin-disulfide reductase [Photobacterium profundum].

LOCUS       WP_011217902             320 aa            linear   BCT 08-JUL-2024
ACCESSION   WP_011217902
VERSION     WP_011217902.1
KEYWORDS    RefSeq.
SOURCE      Photobacterium profundum
  ORGANISM  Photobacterium profundum
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Vibrionales; Vibrionaceae; Photobacterium.
REFERENCE   1  (residues 1 to 320)
  AUTHORS   Lin,K., O'Brien,K.M., Trujillo,C., Wang,R., Wallach,J.B.,
            Schnappinger,D. and Ehrt,S.
  TITLE     Mycobacterium tuberculosis Thioredoxin Reductase Is Essential for
            Thiol Redox Homeostasis but Plays a Minor Role in Antioxidant
            Defense
  JOURNAL   PLoS Pathog 12 (6), e1005675 (2016)
   PUBMED   27249779
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 320)
  AUTHORS   Kashima,Y. and Ishikawa,K.
  TITLE     A hyperthermostable novel protein-disulfide oxidoreductase is
            reduced by thioredoxin reductase from hyperthermophilic archaeon
            Pyrococcus horikoshii
  JOURNAL   Arch Biochem Biophys 418 (2), 179-185 (2003)
   PUBMED   14522589
REFERENCE   3  (residues 1 to 320)
  AUTHORS   Prongay,A.J., Engelke,D.R. and Williams,C.H. Jr.
  TITLE     Characterization of two active site mutations of thioredoxin
            reductase from Escherichia coli
  JOURNAL   J Biol Chem 264 (5), 2656-2664 (1989)
   PUBMED   2644268
  REMARK    Erratum:[J Biol Chem 1989 Jul 15;264(20):12113]
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: TIGR01292.1
            Evidence Source    :: JCVI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..320
                     /organism="Photobacterium profundum"
                     /db_xref="taxon:74109"
     gene            1..320
                     /gene="trxB"
     Protein         1..320
                     /product="thioredoxin-disulfide reductase"
                     /EC_number="1.8.1.9"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0004791 - thioredoxin-disulfide reductase
                     (NADPH) activity [Evidence IEA]"
                     /GO_function="GO:0071949 - FAD binding [Evidence IEA]"
                     /GO_process="GO:0019430 - removal of superoxide radicals
                     [Evidence IEA]"
                     /calculated_mol_wt=34458
     Region          1..319
                     /region_name="PRK10262"
                     /note="thioredoxin reductase; Provisional"
                     /db_xref="CDD:182343"
ORIGIN      
        1 msnvrhcnll ilgsgpagyt aavyaaranl npvmitgmqq ggqlttttev enwpgdaegl
       61 tgpalmdrmk ehaekfetei ifdhinetdf sqspfrlkgd naeytcdali istgasakyl
      121 gleseeafkg rgvsacatcd gffyrnqkva vvgggntave ealylsnias evhiihrrdt
      181 frsekilikr lmdkvengni vlhtdrtlee vlgdemgvtg vrikdtqsna tedlevmgaf
      241 iaighqpnta ifegqleman gyisvqsgtq gnatqtsveg vfaagdvmdh tyrqaitsag
      301 tgcmaaldae ryldaleqqk