leucine--tRNA ligase [Vibrio vulnificus].

LOCUS       WP_011078381             857 aa            linear   BCT 23-MAY-2024
ACCESSION   WP_011078381
VERSION     WP_011078381.1
KEYWORDS    RefSeq.
SOURCE      Vibrio vulnificus
  ORGANISM  Vibrio vulnificus
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Vibrionales; Vibrionaceae; Vibrio.
REFERENCE   1  (residues 1 to 857)
  AUTHORS   Liu,Y., Liao,J., Zhu,B., Wang,E.D. and Ding,J.
  TITLE     Crystal structures of the editing domain of Escherichia coli
            leucyl-tRNA synthetase and its complexes with Met and Ile reveal a
            lock-and-key mechanism for amino acid discrimination
  JOURNAL   Biochem J 394 (Pt 2), 399-407 (2006)
   PUBMED   16277600
REFERENCE   2  (residues 1 to 857)
  AUTHORS   Fukunaga,R. and Yokoyama,S.
  TITLE     Aminoacylation complex structures of leucyl-tRNA synthetase and
            tRNALeu reveal two modes of discriminator-base recognition
  JOURNAL   Nat Struct Mol Biol 12 (10), 915-922 (2005)
   PUBMED   16155584
REFERENCE   3  (residues 1 to 857)
  AUTHORS   Zhao,M.W., Zhu,B., Hao,R., Xu,M.G., Eriani,G. and Wang,E.D.
  TITLE     Leucyl-tRNA synthetase from the ancestral bacterium Aquifex
            aeolicus contains relics of synthetase evolution
  JOURNAL   EMBO J 24 (7), 1430-1439 (2005)
   PUBMED   15775966
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: TIGR00396.1
            Evidence Source    :: JCVI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..857
                     /organism="Vibrio vulnificus"
                     /db_xref="taxon:672"
     gene            1..857
                     /gene="leuS"
     Protein         1..857
                     /product="leucine--tRNA ligase"
                     /EC_number="6.1.1.4"
                     /GO_function="GO:0000166 - nucleotide binding [Evidence
                     IEA]"
                     /GO_function="GO:0004823 - leucine-tRNA ligase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006429 - leucyl-tRNA aminoacylation
                     [Evidence IEA]"
                     /calculated_mol_wt=96546
     Region          1..857
                     /region_name="LeuS"
                     /note="Leucyl-tRNA synthetase [Translation, ribosomal
                     structure and biogenesis]; COG0495"
                     /db_xref="CDD:440261"
ORIGIN      
        1 mqeqynpqdi eqkvqqhwdn nktfvvtedp tkekfyclsm fpypsgrlhm ghvrnytigd
       61 vvsrfqrlqg knvmqpigwd afglpaenaa vknntapapw tyenieymkn qlkllgfgyd
      121 wnrefatctp eyyrweqeff tklyekglvy kktssvnwcp ndqtvlaneq vedgccwrcd
      181 tpveqkeipq wfikiteyaq ellddldkle gwpemvktmq rnwigrsegv elkfevkgqq
      241 dlevyttrpd tlmgvtyvgi aaghplakia aennpelaaf ieeckntkva eaelatmekk
      301 gmatgltaih plngrevpvy vanfvlmdyg tgavmavpah dqrdfefatk ygldiipvik
      361 pidgseldis eaaytekgvl fdsgefdgle fqaafdaiaa kleaegkgtk tvnfrlrdwg
      421 vsrqrywgap ipmvttedgq vhpvpadqlp vilpedvvmd gvtspikadk ewakttfnge
      481 palretdtfd tfmesswyya rycspqaddi ldpekanywl pvdqyiggie hacmhllysr
      541 ffhkllrdag yvtsdepfkq llcqgmvlad afyytndkgg kewvsptevk verdgkgrit
      601 savdnegrnv ehsgmikmsk sknngidpqe mvdkygadtv rlfmmfaspa dmtlewqesg
      661 veganrflkr vwklvnehts kgaaeavdaa alsgdqkalr rdvhktiakv tddvarrqtf
      721 ntaiaavmel mnklakapqe saqdrailde alkavvamly pitphicfem wtalgqqdid
      781 naswptydeq alvedekliv vqvngkvrgk itvaadatke qveeiglnee nvskhldgvt
      841 irkviyvpgk llsivan