bifunctional phosphopantothenoylcysteine

LOCUS       WP_011069561             430 aa            linear   BCT 17-JUN-2024
            decarboxylase/phosphopantothenate--cysteine ligase CoaBC [Shigella
            flexneri].
ACCESSION   WP_011069561
VERSION     WP_011069561.1
KEYWORDS    RefSeq.
SOURCE      Shigella flexneri
  ORGANISM  Shigella flexneri
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Shigella.
REFERENCE   1  (residues 1 to 430)
  AUTHORS   Strauss,E., Kinsland,C., Ge,Y., McLafferty,F.W. and Begley,T.P.
  TITLE     Phosphopantothenoylcysteine synthetase from Escherichia coli.
            Identification and characterization of the last unidentified
            coenzyme A biosynthetic enzyme in bacteria
  JOURNAL   J Biol Chem 276 (17), 13513-13516 (2001)
   PUBMED   11278255
REFERENCE   2  (residues 1 to 430)
  AUTHORS   Spitzer,E.D., Jimenez-Billini,H.E. and Weiss,B.
  TITLE     beta-Alanine auxotrophy associated with dfp, a locus affecting DNA
            synthesis in Escherichia coli
  JOURNAL   J Bacteriol 170 (2), 872-876 (1988)
   PUBMED   3123465
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: TIGR00521.1
            Evidence Source    :: JCVI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..430
                     /organism="Shigella flexneri"
                     /db_xref="taxon:623"
     gene            1..430
                     /gene="coaBC"
     Protein         1..430
                     /product="bifunctional phosphopantothenoylcysteine
                     decarboxylase/phosphopantothenate--cysteine ligase CoaBC"
                     /EC_number="4.1.1.36"
                     /EC_number="6.3.2.5"
                     /GO_function="GO:0004632 - phosphopantothenate--cysteine
                     ligase activity [Evidence IEA]"
                     /GO_function="GO:0004633 - phosphopantothenoylcysteine
                     decarboxylase activity [Evidence IEA]"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /GO_process="GO:0015937 - coenzyme A biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0015941 - pantothenate catabolic process
                     [Evidence IEA]"
                     /calculated_mol_wt=46112
     Region          26..426
                     /region_name="CoaBC"
                     /note="Phosphopantothenoylcysteine
                     synthetase/decarboxylase CoaBC [Coenzyme transport and
                     metabolism]; COG0452"
                     /db_xref="CDD:440221"
ORIGIN      
        1 mkarqqkycd kianfwchpt gkiimslagk kivlgvsggi aayktpelvr rlrdrgadvr
       61 vamteaakaf itplslqavs gypvsdslld paaeaamghi elgkwadlvi lapatadlia
      121 rvaagmandl vsticlatpa pvavlpamnq qmyraaatqh nlevlasrgl liwgpdsgsq
      181 acgdigpgrm ldpltivdma vahfspvndl khlnimitag ptrepldpvr yisnhssgkm
      241 gfaiaaaaar rganvtlvsg pvslptppfv krvdvmtala meaavnasvq qqnifigcaa
      301 vadyraatva pekikkqatq gdeltikmvk npdivagvaa lkdhrpyvvg faaetnnvee
      361 yarqkrirkn ldlicandvs qptqgfnsdn nalhlfwqdg dkvlplerke llgqllldei
      421 vtrydeknrr