phosphatase PAP2 family protein [Shigella flexneri].

LOCUS       WP_011069400             236 aa            linear   BCT 01-JAN-2025
ACCESSION   WP_011069400
VERSION     WP_011069400.1
KEYWORDS    RefSeq.
SOURCE      Shigella flexneri
  ORGANISM  Shigella flexneri
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Shigella.
REFERENCE   1  (residues 1 to 236)
  AUTHORS   Littlechild,J., Garcia-Rodriguez,E., Dalby,A. and Isupov,M.
  TITLE     Structural and functional comparisons between vanadium
            haloperoxidase and acid phosphatase enzymes
  JOURNAL   J Mol Recognit 15 (5), 291-296 (2002)
   PUBMED   12447906
REFERENCE   2  (residues 1 to 236)
  AUTHORS   Neuwald,A.F.
  TITLE     An unexpected structural relationship between integral membrane
            phosphatases and soluble haloperoxidases
  JOURNAL   Protein Sci 6 (8), 1764-1767 (1997)
   PUBMED   9260289
REFERENCE   3  (residues 1 to 236)
  AUTHORS   Hemrika,W., Renirie,R., Dekker,H.L., Barnett,P. and Wever,R.
  TITLE     From phosphatases to vanadium peroxidases: a similar architecture
            of the active site
  JOURNAL   Proc Natl Acad Sci U S A 94 (6), 2145-2149 (1997)
   PUBMED   9122162
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 10130209
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..236
                     /organism="Shigella flexneri"
                     /db_xref="taxon:623"
     Protein         1..236
                     /product="phosphatase PAP2 family protein"
                     /GO_process="GO:0008610 - lipid biosynthetic process
                     [Evidence IEA]"
                     /calculated_mol_wt=27742
     Region          68..218
                     /region_name="PAP2_Aur1_like"
                     /note="PAP2_like proteins, Aur1_like subfamily. Yeast
                     Aur1p or Ipc1p is necessary for the addition of inositol
                     phosphate to ceramide, an essential step in yeast
                     sphingolipid synthesis, and is the target of several
                     antifungal compounds such as aureobasidin; cd03386"
                     /db_xref="CDD:239481"
     Site            order(119,127,153..155,189,195,199)
                     /site_type="active"
                     /db_xref="CDD:239481"
ORIGIN      
        1 mcgaflrfrw rcvviterrn vllqgagwll llapffffty gslnqftavq dlnshdipsq
       61 vfgwetaipf lpwtivpyws ldllygfslf vcsstfeqrr lvhrlilatv maccgfflyp
      121 lkfsfirpev sgvtgwlfsq lelfdlpynq spslhiilcw llwrhfrqhl avrwrkvcgg
      181 wflliaistl ttwqhhfidv itglavgmli dwmvpvdrrw nyqkldqrri kialpy