nitroreductase NfsA [Shigella flexneri].

LOCUS       WP_011069298             235 aa            linear   BCT 10-JUL-2019
ACCESSION   WP_011069298
VERSION     WP_011069298.1
KEYWORDS    RefSeq.
SOURCE      Shigella flexneri
  ORGANISM  Shigella flexneri
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Shigella.
REFERENCE   1  (residues 1 to 235)
  AUTHORS   Shanmugam,D., Esak,S.B. and Narayanaswamy,A.
  TITLE     Molecular Characterisation of nfsA Gene in Nitrofurantoin Resistant
            Uropathogens
  JOURNAL   J Clin Diagn Res 10 (6), DC05-DC09 (2016)
   PUBMED   27504284
REFERENCE   2  (residues 1 to 235)
  AUTHORS   Nokhbeh,M.R., Boroumandi,S., Pokorny,N., Koziarz,P., Paterson,E.S.
            and Lambert,I.B.
  TITLE     Identification and characterization of SnrA, an inducible
            oxygen-insensitive nitroreductase in Salmonella enterica serovar
            Typhimurium TA1535
  JOURNAL   Mutat. Res. 508 (1-2), 59-70 (2002)
   PUBMED   12379462
REFERENCE   3  (residues 1 to 235)
  AUTHORS   Zenno,S., Koike,H., Kumar,A.N., Jayaraman,R., Tanokura,M. and
            Saigo,K.
  TITLE     Biochemical characterization of NfsA, the Escherichia coli major
            nitroreductase exhibiting a high amino acid sequence homology to
            Frp, a Vibrio harveyi flavin oxidoreductase
  JOURNAL   J. Bacteriol. 178 (15), 4508-4514 (1996)
   PUBMED   8755878
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: BlastRule
            Evidence Accession :: NBR006554
            Evidence Source    :: NCBI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..235
                     /organism="Shigella flexneri"
                     /db_xref="taxon:623"
     gene            1..235
                     /gene="nfsA"
     Protein         1..235
                     /product="nitroreductase NfsA"
                     /EC_number="1.5.1.38"
                     /calculated_mol_wt=26164
     Region          1..235
                     /region_name="PRK10765"
                     /note="oxygen-insensitive NADPH nitroreductase"
                     /db_xref="CDD:182710"
     Site            order(24,26..28,30..33,36..39,41..48,51,77,96..98,
                     100..101,104..105,108..109,112,116..117,123,128,138..139,
                     141,148,162..165,167,169..172,187,207..208,211,215..220)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:380322"
     Site            order(33..35,37,62,64,101..102,105,122..126,162,164)
                     /site_type="other"
                     /note="FMN binding site [chemical binding]"
                     /db_xref="CDD:380322"
     Site            order(37,128..129,160,162,194..195,198)
                     /site_type="other"
                     /note="NADP binding site [chemical binding]"
                     /db_xref="CDD:380322"
ORIGIN      
        1 mciylnlmil ikiirgfisa qceaiinsar atssssflqc ssiiritdka lreelvtltg
       61 gqkhvaqaae fwvfcadfnr hlqicpdaql glaeqlllgv vdtammaqna ltaaeslglg
      121 gvyigglrnn ieavtkllkl pqhvlplfgl clgwpadnpd lkprlpasil vhensyqpld
      181 kdalaqydeq laeyyltrgs nnrwdtwsdh irrtiikesr pfildylhkq gwatr