bifunctional transcriptional activator/DNA repair enzyme AdaA

LOCUS       WP_010989933             188 aa            linear   BCT 20-FEB-2025
            [Listeria monocytogenes].
ACCESSION   WP_010989933
VERSION     WP_010989933.1
KEYWORDS    RefSeq.
SOURCE      Listeria monocytogenes
  ORGANISM  Listeria monocytogenes
            Bacteria; Bacillati; Bacillota; Bacilli; Bacillales; Listeriaceae;
            Listeria.
REFERENCE   1  (residues 1 to 188)
  AUTHORS   Aravind,L., Anantharaman,V., Balaji,S., Babu,M.M. and Iyer,L.M.
  TITLE     The many faces of the helix-turn-helix domain: transcription
            regulation and beyond
  JOURNAL   FEMS Microbiol Rev 29 (2), 231-262 (2005)
   PUBMED   15808743
REFERENCE   2  (residues 1 to 188)
  AUTHORS   Rosinski,J.A. and Atchley,W.R.
  TITLE     Molecular evolution of helix-turn-helix proteins
  JOURNAL   J Mol Evol 49 (3), 301-309 (1999)
   PUBMED   10473770
REFERENCE   3  (residues 1 to 188)
  AUTHORS   Wintjens,R. and Rooman,M.
  TITLE     Structural classification of HTH DNA-binding domains and
            protein-DNA interaction modes
  JOURNAL   J Mol Biol 262 (2), 294-313 (1996)
   PUBMED   8831795
REFERENCE   4  (residues 1 to 188)
  AUTHORS   Morohoshi,F., Hayashi,K. and Munakata,N.
  TITLE     Molecular analysis of Bacillus subtilis ada mutants deficient in
            the adaptive response to simple alkylating agents
  JOURNAL   J Bacteriol 173 (24), 7834-7840 (1991)
   PUBMED   1744039
REFERENCE   5  (residues 1 to 188)
  AUTHORS   Morohoshi,F., Hayashi,K. and Munakata,N.
  TITLE     Bacillus subtilis ada operon encodes two DNA alkyltransferases
  JOURNAL   Nucleic Acids Res 18 (18), 5473-5480 (1990)
   PUBMED   2120677
REFERENCE   6  (residues 1 to 188)
  AUTHORS   Brennan,R.G. and Matthews,B.W.
  TITLE     The helix-turn-helix DNA binding motif
  JOURNAL   J Biol Chem 264 (4), 1903-1906 (1989)
   PUBMED   2644244
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 11450612
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..188
                     /organism="Listeria monocytogenes"
                     /db_xref="taxon:1639"
     Protein         1..188
                     /product="bifunctional transcriptional activator/DNA
                     repair enzyme AdaA"
                     /EC_number="2.1.1.-"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription
                     factor activity [Evidence IEA]"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006281 - DNA repair [Evidence IEA]"
                     /GO_process="GO:0032259 - methylation [Evidence IEA]"
                     /calculated_mol_wt=21433
     Region          1..>181
                     /region_name="AdaA"
                     /note="Methylphosphotriester-DNA--protein-cysteine
                     methyltransferase (N-terminal fragment of Ada), contains
                     Zn-binding and two AraC-type DNA-binding domains
                     [Replication, recombination and repair]; COG2169"
                     /db_xref="CDD:441772"
ORIGIN      
        1 msdyyltkkr wqaistndkt adgaffygvt stkifcypsc ksrlpkkeni vifhsaeeaf
       61 shgyrackrc ksggsalpdt ewvnniemyi kenfakaltl kiiaddchgs pyhlhrtfkr
      121 itmitpityl envrinyakm qltttnqsie tigkmagfpn pshfsttfkr htglspnqfr
      181 ktiikkln