MDR family MFS transporter [Listeria monocytogenes].

LOCUS       WP_010989881             415 aa            linear   BCT 24-DEC-2024
ACCESSION   WP_010989881
VERSION     WP_010989881.1
KEYWORDS    RefSeq.
SOURCE      Listeria monocytogenes
  ORGANISM  Listeria monocytogenes
            Bacteria; Bacillati; Bacillota; Bacilli; Bacillales; Listeriaceae;
            Listeria.
REFERENCE   1  (residues 1 to 415)
  AUTHORS   Quistgaard,E.M., Low,C., Guettou,F. and Nordlund,P.
  TITLE     Understanding transport by the major facilitator superfamily (MFS):
            structures pave the way
  JOURNAL   Nat Rev Mol Cell Biol 17 (2), 123-132 (2016)
   PUBMED   26758938
REFERENCE   2  (residues 1 to 415)
  AUTHORS   Kumar,S., He,G., Kakarla,P., Shrestha,U., Ranjana,K.C.,
            Ranaweera,I., Willmon,T.M., Barr,S.R., Hernandez,A.J. and
            Varela,M.F.
  TITLE     Bacterial Multidrug Efflux Pumps of the Major Facilitator
            Superfamily as Targets for Modulation
  JOURNAL   Infect Disord Drug Targets 16 (1), 28-43 (2016)
   PUBMED   27052334
REFERENCE   3  (residues 1 to 415)
  AUTHORS   Zhang,X.C., Zhao,Y., Heng,J. and Jiang,D.
  TITLE     Energy coupling mechanisms of MFS transporters
  JOURNAL   Protein Sci 24 (10), 1560-1579 (2015)
   PUBMED   26234418
REFERENCE   4  (residues 1 to 415)
  AUTHORS   Yan,N.
  TITLE     Structural Biology of the Major Facilitator Superfamily
            Transporters
  JOURNAL   Annu Rev Biophys 44, 257-283 (2015)
   PUBMED   26098515
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 13023665
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..415
                     /organism="Listeria monocytogenes"
                     /db_xref="taxon:1639"
     Protein         1..415
                     /product="MDR family MFS transporter"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport
                     [Evidence IEA]"
                     /calculated_mol_wt=45753
     Region          9..400
                     /region_name="MFS_MdtH_MDR_like"
                     /note="Multidrug resistance protein MdtH and similar
                     multidrug resistance (MDR) transporters of the Major
                     Facilitator Superfamily; cd17329"
                     /db_xref="CDD:340887"
     Site            order(19..20,23..24,27,58,113..114,116..118,121,141,
                     144..145,148,225,228..229,232..234,237,279,283,332..333,
                     337,341,357,360..361,364..365,368)
                     /site_type="other"
                     /note="putative chemical substrate binding pocket
                     [chemical binding]"
                     /db_xref="CDD:340887"
ORIGIN      
        1 mfrelhpnir ariliqflsk vigsmifpfm aiyfsmeins svagfllmin vlaqflagmy
       61 gghladiigr kklmvtgell kvfaflgmvl cnspmfhspw itfvmlliig vaqglinpag
      121 eamlidvstl enrsfmysvs ywannlsimi gimvggwffv dylfpllvvl fimsfvtawl
      181 tislisetlq qkemphkgsy glmgmlknyg qvlhdyrfll ytiggiaims iefqrsnyis
      241 vrlaedvkal lvhlgplgni slngvqivsv ltavntlfiv lftvpiarfv tkraqqpimy
      301 vgftlfalgf avcafannla vlllatmvls igellyvptr qtilaaivdd dkrgaymafn
      361 giifqigkmi gsvslvfapf igkygmgaft iilgilsivf savalksgwe kvlvk