bifunctional phosphopantothenoylcysteine

LOCUS       WP_010989823             399 aa            linear   BCT 17-JUN-2024
            decarboxylase/phosphopantothenate--cysteine ligase CoaBC [Listeria
            monocytogenes].
ACCESSION   WP_010989823
VERSION     WP_010989823.1
KEYWORDS    RefSeq.
SOURCE      Listeria monocytogenes
  ORGANISM  Listeria monocytogenes
            Bacteria; Bacillati; Bacillota; Bacilli; Bacillales; Listeriaceae;
            Listeria.
REFERENCE   1  (residues 1 to 399)
  AUTHORS   Strauss,E., Kinsland,C., Ge,Y., McLafferty,F.W. and Begley,T.P.
  TITLE     Phosphopantothenoylcysteine synthetase from Escherichia coli.
            Identification and characterization of the last unidentified
            coenzyme A biosynthetic enzyme in bacteria
  JOURNAL   J Biol Chem 276 (17), 13513-13516 (2001)
   PUBMED   11278255
REFERENCE   2  (residues 1 to 399)
  AUTHORS   Spitzer,E.D., Jimenez-Billini,H.E. and Weiss,B.
  TITLE     beta-Alanine auxotrophy associated with dfp, a locus affecting DNA
            synthesis in Escherichia coli
  JOURNAL   J Bacteriol 170 (2), 872-876 (1988)
   PUBMED   3123465
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: TIGR00521.1
            Evidence Source    :: JCVI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..399
                     /organism="Listeria monocytogenes"
                     /db_xref="taxon:1639"
     gene            1..399
                     /gene="coaBC"
     Protein         1..399
                     /product="bifunctional phosphopantothenoylcysteine
                     decarboxylase/phosphopantothenate--cysteine ligase CoaBC"
                     /EC_number="4.1.1.36"
                     /EC_number="6.3.2.5"
                     /GO_function="GO:0004632 - phosphopantothenate--cysteine
                     ligase activity [Evidence IEA]"
                     /GO_function="GO:0004633 - phosphopantothenoylcysteine
                     decarboxylase activity [Evidence IEA]"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /GO_process="GO:0015937 - coenzyme A biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0015941 - pantothenate catabolic process
                     [Evidence IEA]"
                     /calculated_mol_wt=43235
     Region          1..399
                     /region_name="CoaBC"
                     /note="Phosphopantothenoylcysteine
                     synthetase/decarboxylase CoaBC [Coenzyme transport and
                     metabolism]; COG0452"
                     /db_xref="CDD:440221"
ORIGIN      
        1 mqgknillav sggiavykav altskltqag anvkvmmtah aqefvpplsf qvlskndvyt
       61 dtfdekkssv vahidladwa dlvivapata nvigkmangi addmvtttil ateapvwvap
      121 amnvhmiqhp avirninrly adgvrfiepe egylacgyvg rgrleepeki vlriaeffqe
      181 dknllqgknv lvtagatrek ldpvryftnh stgkmgfsia esaarhganv tlittskalp
      241 vphgveaiyv esaeemhqav nerkvsqdif vmtaavadyt paqvsdqkik kqpgdftiam
      301 krtkdillei gqhktseqvv igfaaetenv eanarkklts knadmivann iseagagfsg
      361 dtnivtfyrk dgssealpil dkkevaehii keaanflrk