methylmalonate-semialdehyde dehydrogenase [Listeria monocytogenes].

LOCUS       WP_010989444             488 aa            linear   BCT 22-FEB-2021
ACCESSION   WP_010989444
VERSION     WP_010989444.1
KEYWORDS    RefSeq.
SOURCE      Listeria monocytogenes
  ORGANISM  Listeria monocytogenes
            Bacteria; Bacillati; Bacillota; Bacilli; Bacillales; Listeriaceae;
            Listeria.
REFERENCE   1  (residues 1 to 488)
  AUTHORS   Talfournier,F., Stines-Chaumeil,C. and Branlant,G.
  TITLE     Methylmalonate-semialdehyde dehydrogenase from Bacillus subtilis:
            substrate specificity and coenzyme A binding
  JOURNAL   J Biol Chem 286 (25), 21971-21981 (2011)
   PUBMED   21515690
REFERENCE   2  (residues 1 to 488)
  AUTHORS   Yoshida,K., Yamaguchi,M., Morinaga,T., Kinehara,M., Ikeuchi,M.,
            Ashida,H. and Fujita,Y.
  TITLE     myo-Inositol catabolism in Bacillus subtilis
  JOURNAL   J Biol Chem 283 (16), 10415-10424 (2008)
   PUBMED   18310071
REFERENCE   3  (residues 1 to 488)
  AUTHORS   Stines-Chaumeil,C., Talfournier,F. and Branlant,G.
  TITLE     Mechanistic characterization of the MSDH (methylmalonate
            semialdehyde dehydrogenase) from Bacillus subtilis
  JOURNAL   Biochem J 395 (1), 107-115 (2006)
   PUBMED   16332250
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: BlastRule
            Evidence Accession :: NBR013863
            Evidence Source    :: NCBI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..488
                     /organism="Listeria monocytogenes"
                     /db_xref="taxon:1639"
     gene            1..488
                     /gene="iolA"
     Protein         1..488
                     /product="methylmalonate-semialdehyde dehydrogenase"
                     /EC_number="1.2.1.27"
                     /calculated_mol_wt=53190
     Region          7..481
                     /region_name="ALDH_F6_MMSDH"
                     /note="Methylmalonate semialdehyde dehydrogenase and ALDH
                     family members 6A1 and 6B2; cd07085"
                     /db_xref="CDD:143404"
     Site            order(64,66,70,73,77,110,113..114,123..130,135,138,141,
                     234,238,241,244,246,417,419..420,422..423,426,429..430,
                     432,434..437,446,450,452,466,473..478,480..481)
                     /site_type="other"
                     /note="tetrameric interface [polypeptide binding]"
                     /db_xref="CDD:143404"
     Site            order(150..153,161,176,179,209,226..229,232,250..252,284,
                     382,384,410)
                     /site_type="other"
                     /note="NAD binding site [chemical binding]"
                     /db_xref="CDD:143404"
     Site            order(153,250,281,284)
                     /site_type="active"
                     /note="catalytic residues [active]"
                     /db_xref="CDD:143404"
ORIGIN      
        1 madvrklkny idgewveskt dkyedvinpa tgevlcqvpi straeldqaa viaeqafekw
       61 sqvavprrar vlfgfqqlli qhkeelarli tlengknlse argevqrgie nvefaagapt
      121 lmmgdslasi atdveaanyr ypvgvvggia pfnfpmmvpc wmfpmaialg nsfilkpser
      181 tpllmeklve lfseaglpkg vfnvvygahd vvngilenei ikavsfvgsk pvgeyvyktg
      241 sanlkrvqal tgaknhtivl ndadledtvt nvisaafgsa gercmacavv tveegiadef
      301 lealrtaaqn vkignglddg vflgpviree nqkrtiayie kgieegaklt vdgretglse
      361 ghfvgptile dvttdmtiwk deifapvlsv irvknlqeav rvanqsefan gaciftnnak
      421 airyfrekid agmlgvnlgv papmaffpfs gwkssfygtl hangkdsvdf ythkkvvtar
      481 yslkgyee