aldo/keto reductase [Listeria monocytogenes].

LOCUS       WP_010989341             327 aa            linear   BCT 01-JAN-2025
ACCESSION   WP_010989341
VERSION     WP_010989341.1
KEYWORDS    RefSeq.
SOURCE      Listeria monocytogenes
  ORGANISM  Listeria monocytogenes
            Bacteria; Bacillati; Bacillota; Bacilli; Bacillales; Listeriaceae;
            Listeria.
REFERENCE   1  (residues 1 to 327)
  AUTHORS   Penning,T.M.
  TITLE     The aldo-keto reductases (AKRs): Overview
  JOURNAL   Chem Biol Interact 234, 236-246 (2015)
   PUBMED   25304492
REFERENCE   2  (residues 1 to 327)
  AUTHORS   Mindnich,R.D. and Penning,T.M.
  TITLE     Aldo-keto reductase (AKR) superfamily: genomics and annotation
  JOURNAL   Hum Genomics 3 (4), 362-370 (2009)
   PUBMED   19706366
REFERENCE   3  (residues 1 to 327)
  AUTHORS   Jin,Y. and Penning,T.M.
  TITLE     Aldo-keto reductases and bioactivation/detoxication
  JOURNAL   Annu Rev Pharmacol Toxicol 47, 263-292 (2007)
   PUBMED   16970545
REFERENCE   4  (residues 1 to 327)
  AUTHORS   Sanli,G., Dudley,J.I. and Blaber,M.
  TITLE     Structural biology of the aldo-keto reductase family of enzymes:
            catalysis and cofactor binding
  JOURNAL   Cell Biochem Biophys 38 (1), 79-101 (2003)
   PUBMED   12663943
REFERENCE   5  (residues 1 to 327)
  AUTHORS   Jez,J.M., Bennett,M.J., Schlegel,B.P., Lewis,M. and Penning,T.M.
  TITLE     Comparative anatomy of the aldo-keto reductase superfamily
  JOURNAL   Biochem J 326 (Pt 3) (Pt 3), 625-636 (1997)
   PUBMED   9307009
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 14442375
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..327
                     /organism="Listeria monocytogenes"
                     /db_xref="taxon:1639"
     Protein         1..327
                     /product="aldo/keto reductase"
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /calculated_mol_wt=36232
     Region          10..307
                     /region_name="AKR_AKR13C1_2"
                     /note="AKR13C family of aldo-keto reductase (AKR);
                     cd19078"
                     /db_xref="CDD:381304"
     Site            order(19..21,52,57,82,123..124,153..154,173,201..207,258,
                     275..280,283,286..287)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:381304"
     Site            order(52,57,82,123)
                     /site_type="active"
                     /note="catalytic tetrad [active]"
                     /db_xref="CDD:381304"
ORIGIN      
        1 mkkrqlgnag lvtselgfgc mglnyhrgpa kdrnemievv rtamdagitm fdtaevygpy
       61 tneelvgeal vgkrnhvqia tkggfkingl nnevdsrpes ikaavegslk rlktdyidly
      121 yihridpsip ieevagtiqn lkqegkilhw glseasakti rrahkvepla aveseysiww
      181 reaekevfpv leelgiglva ysplgrgylt gkldinadfn andnrgglpr fqkeameanq
      241 vlldfmkeia deqnvttaql alawildqkp wivpipgttr psrieenias teihfddgar
      301 qkiadalsqi eivgdrysaa enkrigk