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LOCUS WP_010989081 334 aa linear BCT 28-MAR-2023 [Salmonella]. ACCESSION WP_010989081 VERSION WP_010989081.1 KEYWORDS RefSeq. SOURCE Salmonella ORGANISM Salmonella Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae. REFERENCE 1 (residues 1 to 334) AUTHORS Bondos,S.E., Swint-Kruse,L. and Matthews,K.S. TITLE Flexibility and Disorder in Gene Regulation: LacI/GalR and Hox Proteins JOURNAL J Biol Chem 290 (41), 24669-24677 (2015) PUBMED 26342073 REFERENCE 2 (residues 1 to 334) AUTHORS Swint-Kruse,L. and Matthews,K.S. TITLE Allostery in the LacI/GalR family: variations on a theme JOURNAL Curr Opin Microbiol 12 (2), 129-137 (2009) PUBMED 19269243 COMMENT REFSEQ: This record represents a single, non-redundant, protein sequence which may be annotated on many different RefSeq genomes from the same, or different, species. ##Evidence-For-Name-Assignment-START## Evidence Category :: Conserved Domain (CDD) Evidence Accession :: Domain architecture ID 11265687 Evidence Source :: NCBI SPARCLE ##Evidence-For-Name-Assignment-END## COMPLETENESS: full length. FEATURES Location/Qualifiers source 1..334 /organism="Salmonella" /db_xref="taxon:590" Protein 1..334 /product="LacI family DNA-binding transcriptional regulator" /GO_function="GO:0000976 - transcription cis-regulatory region binding [Evidence IEA]" /GO_function="GO:0003677 - DNA binding [Evidence IEA]" /GO_function="GO:0003700 - DNA-binding transcription factor activity [Evidence IEA]" /GO_function="GO:0043565 - sequence-specific DNA binding [Evidence IEA]" /GO_process="GO:0006351 - DNA-templated transcription [Evidence IEA]" /GO_process="GO:0006355 - regulation of DNA-templated transcription [Evidence IEA]" /GO_process="GO:0045892 - negative regulation of DNA-templated transcription [Evidence IEA]" /calculated_mol_wt=36030 Region 10..79 /region_name="HTH_LACI" /note="helix_turn _helix lactose operon repressor; smart00354" /db_xref="CDD:197675" Site order(21..25,27..28,31,36..37,40,53,56,59..60,62..63) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:143331" Site 53..62 /site_type="active" /note="domain linker motif [active]" /db_xref="CDD:143331" Region 69..333 /region_name="PBP1_GntR" /note="ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; cd01575" /db_xref="CDD:380489" Site order(77,83,86,90,99..102,115,118..119,121..122,226,228, 231,259) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:380489" Site order(81..82,85,130,153,166,200,225,278,295) /site_type="other" /note="putative ligand binding site [chemical binding]" /db_xref="CDD:380489" ORIGIN 1 mkrtksprap tledvarsag lspmtvsral nspqlvrpkt vekvmqavrv tgyipnalag 61 glasrrskli avvvpqinnn mfvdtiqsls delarrgyhi llcvagyteq teaelvatll 121 srrpdgvvlt gihhtielkk vilnaaipvv eiwdltptpl dmlvgfshek vgqatgeyll 181 skgyrrpgll wtadrraaqr kqglcsvlqr haihavpqvd vplpaslslg rsglsqlfde 241 gtfdvivcss dtlaqgamme aesrglriph dlavigfgdl dfaasnrpsi ttvsvdrrai 301 gqraatllad rieqkpcaea ivdigfhlig resa