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Tir-cytoskeleton coupling protein TccP [Escherichia coli].


LOCUS       WP_010917831             337 aa            linear   BCT 04-APR-2022
ACCESSION   WP_010917831
VERSION     WP_010917831.1
KEYWORDS    RefSeq.
SOURCE      Escherichia coli
  ORGANISM  Escherichia coli
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Escherichia.
REFERENCE   1  (residues 1 to 337)
  AUTHORS   Sallee,N.A., Rivera,G.M., Dueber,J.E., Vasilescu,D., Mullins,R.D.,
            Mayer,B.J. and Lim,W.A.
  TITLE     The pathogen protein EspF(U) hijacks actin polymerization using
            mimicry and multivalency
  JOURNAL   Nature 454 (7207), 1005-1008 (2008)
   PUBMED   18650806
REFERENCE   2  (residues 1 to 337)
  AUTHORS   Ogura,Y., Ooka,T., Whale,A., Garmendia,J., Beutin,L., Tennant,S.,
            Krause,G., Morabito,S., Chinen,I., Tobe,T., Abe,H., Tozzoli,R.,
            Caprioli,A., Rivas,M., Robins-Browne,R., Hayashi,T. and Frankel,G.
  TITLE     TccP2 of O157:H7 and non-O157 enterohemorrhagic Escherichia coli
            (EHEC): challenging the dogma of EHEC-induced actin polymerization
  JOURNAL   Infect Immun 75 (2), 604-612 (2007)
   PUBMED   17101643
REFERENCE   3  (residues 1 to 337)
  AUTHORS   Garmendia,J., Phillips,A.D., Carlier,M.F., Chong,Y., Schuller,S.,
            Marches,O., Dahan,S., Oswald,E., Shaw,R.K., Knutton,S. and
            Frankel,G.
  TITLE     TccP is an enterohaemorrhagic Escherichia coli O157:H7 type III
            effector protein that couples Tir to the actin-cytoskeleton
  JOURNAL   Cell Microbiol 6 (12), 1167-1183 (2004)
   PUBMED   15527496
REFERENCE   4  (residues 1 to 337)
  AUTHORS   Campellone,K.G., Robbins,D. and Leong,J.M.
  TITLE     EspFU is a translocated EHEC effector that interacts with Tir and
            N-WASP and promotes Nck-independent actin assembly
  JOURNAL   Dev Cell 7 (2), 217-228 (2004)
   PUBMED   15296718
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: BlastRule
            Evidence Accession :: NBR006077
            Evidence Source    :: NCBI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..337
                     /organism="Escherichia coli"
                     /db_xref="taxon:562"
     gene            1..337
                     /gene="tccP"
                     /gene_synonym="espF(U)"
     Protein         1..337
                     /product="Tir-cytoskeleton coupling protein TccP"
                     /calculated_mol_wt=37061
     Region          96..142
                     /region_name="EspF"
                     /note="EspF protein repeat; pfam04806"
                     /db_xref="CDD:398464"
     Region          143..189
                     /region_name="EspF"
                     /note="EspF protein repeat; pfam04806"
                     /db_xref="CDD:398464"
     Region          190..236
                     /region_name="EspF"
                     /note="EspF protein repeat; pfam04806"
                     /db_xref="CDD:398464"
     Region          237..283
                     /region_name="EspF"
                     /note="EspF protein repeat; pfam04806"
                     /db_xref="CDD:398464"
     Region          284..330
                     /region_name="EspF"
                     /note="EspF protein repeat; pfam04806"
                     /db_xref="CDD:398464"
ORIGIN      
        1 minnvsslfp tvnrnitavy kkssfsvspq kitlnpvkis spfspssssi sattlfrapn
       61 ahsasfhrqs taesslhqql pnvrqrliqh laehgikpar smaehippap nwpappppvq
      121 neqsrplpdv aqrlvqhlae hgiqparnma ehippapnwp applpvqneq srplpdvaqr
      181 lvqhlaehgi qparsmaehi ppapnwpapp ppvqneqsrp lpdvaqrlmq hlaehgiqpa
      241 rnmaehippa pnwpaptppv qneqsrplpd vaqrlmqhla ehgiqparnm aehippapnw
      301 paptppvqne qsrplpdvaq rlmqhlaehg intskrs