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adenosylcobalamin-dependent ribonucleoside-diphosphate reductase


LOCUS       WP_010895708             734 aa            linear   BCT 04-JUN-2024
            [Pseudomonas aeruginosa].
ACCESSION   WP_010895708
VERSION     WP_010895708.1
KEYWORDS    RefSeq.
SOURCE      Pseudomonas aeruginosa
  ORGANISM  Pseudomonas aeruginosa
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Pseudomonadales; Pseudomonadaceae; Pseudomonas.
REFERENCE   1  (residues 1 to 734)
  AUTHORS   Jordan,A., Torrents,E., Jeanthon,C., Eliasson,R., Hellman,U.,
            Wernstedt,C., Barbe,J., Gibert,I. and Reichard,P.
  TITLE     B12-dependent ribonucleotide reductases from deeply rooted
            eubacteria are structurally related to the aerobic enzyme from
            Escherichia coli
  JOURNAL   Proc Natl Acad Sci U S A 94 (25), 13487-13492 (1997)
   PUBMED   9391052
REFERENCE   2  (residues 1 to 734)
  AUTHORS   Riera,J., Robb,F.T., Weiss,R. and Fontecave,M.
  TITLE     Ribonucleotide reductase in the archaeon Pyrococcus furiosus: a
            critical enzyme in the evolution of DNA genomes?
  JOURNAL   Proc Natl Acad Sci U S A 94 (2), 475-478 (1997)
   PUBMED   9012808
REFERENCE   3  (residues 1 to 734)
  AUTHORS   Tauer,A. and Benner,S.A.
  TITLE     The B12-dependent ribonucleotide reductase from the archaebacterium
            Thermoplasma acidophila: an evolutionary solution to the
            ribonucleotide reductase conundrum
  JOURNAL   Proc Natl Acad Sci U S A 94 (1), 53-58 (1997)
   PUBMED   8990160
REFERENCE   4  (residues 1 to 734)
  AUTHORS   Tsai,P.K. and Hogenkamp,H.P.
  TITLE     The purification and characterization of an
            adenosylcobalamin-dependent ribonucleoside diphosphate reductase
            from Corynebacterium nephridii
  JOURNAL   J Biol Chem 255 (4), 1273-1278 (1980)
   PUBMED   6986368
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: TIGR02504.1
            Evidence Source    :: JCVI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..734
                     /organism="Pseudomonas aeruginosa"
                     /db_xref="taxon:287"
     Protein         1..734
                     /product="adenosylcobalamin-dependent
                     ribonucleoside-diphosphate reductase"
                     /EC_number="1.17.4.1"
                     /GO_function="GO:0000166 - nucleotide binding [Evidence
                     IEA]"
                     /GO_function="GO:0004748 - ribonucleoside-diphosphate
                     reductase activity, thioredoxin disulfide as acceptor
                     [Evidence IEA]"
                     /GO_function="GO:0031419 - cobalamin binding [Evidence
                     IEA]"
                     /calculated_mol_wt=82610
     Region          45..680
                     /region_name="NrdJ_Z"
                     /note="ribonucleoside-diphosphate reductase,
                     adenosylcobalamin-dependent; TIGR02504"
                     /db_xref="CDD:274168"
ORIGIN      
        1 mlrtvagfgr pnnhrevnqr maktdarspr tergtialqd asqdiwdkky rlkskdgtpv
       61 dasvdgtwqr varaladved kasrehwygr flwalrngai pagriisnag alghkpatst
      121 inctvsgtiq dsmdnilekv heagltlkag cgigyefstl rprgayvsga gaytsgplsf
      181 mdiydkmcft vssaggrrga qmgtfdvshp dvrefirakr edgrlrqfnl sllitdqfmq
      241 aveqdadwpl vfpvhvkerd eidlddpnav vwrewpiqdd yvqradglva ckvygqvrar
      301 hlwdmimvst ydyaepgfil idrvnelnnn wwceairatn pcgeqplppy gscllgsvnl
      361 tcfveqpfgd earfdwdrfr evvrvftrml dnvveinglp leqqrqeilg krrhgmgflg
      421 lgstltllkl rygspeacvf teevaremal vgwevalela rekgpapila qdyevtaeml
      481 rkrpemaadg ykagdrirgs vlhakysrym qrvaehapel iealaetgar fthhssiapt
      541 gtislslann asngiepsfa hhysrnlire grktkekvev ysyellayrt lvnaqalpds
      601 ddparrlpdy fitadsvtpa qhmdiqaaaq kwvdssiskt anvptdypfe dfkdiyryaw
      661 hqglkgcttf rfnpeafqgv lvkesdlekt ryrfeledgs vvefkgneqv eydgeihtaa
      721 nlfdalkegy ygky