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LOCUS WP_010895660 740 aa linear BCT 17-NOV-2023 ACCESSION WP_010895660 VERSION WP_010895660.1 KEYWORDS RefSeq. SOURCE Pseudomonas aeruginosa ORGANISM Pseudomonas aeruginosa Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas. REFERENCE 1 (residues 1 to 740) AUTHORS Bublitz,M., Morth,J.P. and Nissen,P. TITLE P-type ATPases at a glance JOURNAL J Cell Sci 124 (Pt 15), 2515-2519 (2011) PUBMED 21768325 REMARK Erratum:[J Cell Sci. 2011 Nov 15;124(Pt 22):3917] REFERENCE 2 (residues 1 to 740) AUTHORS Palmgren,M.G. and Nissen,P. TITLE P-type ATPases JOURNAL Annu Rev Biophys 40, 243-266 (2011) PUBMED 21351879 REFERENCE 3 (residues 1 to 740) AUTHORS Apell,H.J. TITLE How do P-type ATPases transport ions? JOURNAL Bioelectrochemistry 63 (1-2), 149-156 (2004) PUBMED 15110265 COMMENT REFSEQ: This record represents a single, non-redundant, protein sequence which may be annotated on many different RefSeq genomes from the same, or different, species. ##Evidence-For-Name-Assignment-START## Evidence Category :: Conserved Domain (CDD) Evidence Accession :: Domain architecture ID 11534186 Evidence Source :: NCBI SPARCLE ##Evidence-For-Name-Assignment-END## COMPLETENESS: full length. FEATURES Location/Qualifiers source 1..740 /organism="Pseudomonas aeruginosa" /db_xref="taxon:287" Protein 1..740 /product="heavy metal translocating P-type ATPase" /EC_number="7.2.2.-" /GO_function="GO:0005524 - ATP binding [Evidence IEA]" /GO_function="GO:0015662 - P-type ion transporter activity [Evidence IEA]" /GO_function="GO:0016887 - ATP hydrolysis activity [Evidence IEA]" /GO_function="GO:0019829 - ATPase-coupled monoatomic cation transmembrane transporter activity [Evidence IEA]" /GO_function="GO:0046872 - metal ion binding [Evidence IEA]" /calculated_mol_wt=78598 Region 45..105 /region_name="HMA" /note="Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; cd00371" /db_xref="CDD:238219" Site order(51..53,56) /site_type="metal-binding" /note="metal-binding site [ion binding]" /db_xref="CDD:238219" Region 141..737 /region_name="P-type_ATPase_Cd-like" /note="P-type heavy metal-transporting ATPase, similar to Staphylococcus aureus plasmid pI258 CadA, a cadmium-efflux ATPase; cd07545" /db_xref="CDD:319845" Site order(391,393,699..700,721,725) /site_type="other" /note="putative HM ion binding site [ion binding]" /db_xref="CDD:319845" Site order(435..437,500,516..518,547,587..589,609,612,615,634, 637) /site_type="other" /note="putative ATP binding site [chemical binding]" /db_xref="CDD:319845" ORIGIN 1 mshehadtcc hghghghdhg hrhaprpava aigtlagnae lrwsdlriea mdcpteerli 61 rdalgrqpav eslefnlmqr llrvqhrfds veplqkliag lgmqavplda gentdgpsqa 121 pakpwwplal agamalasei vewfglapdw vvaglallai lgaglptyrk gwialknrnl 181 ninalmsiav tgavligqwp eaamvsvlfa iaelieaksl drarnairgl lqlapeqatv 241 lvggewkelp akqveleatv rvkpgerial dgevtsgrss vnqapitges lpvekevgep 301 vfagsingeg aleyrvtrra ddstlariih aveeaqgsra ptqrfvdsfa rvytpvvfli 361 alatavlppl lfggawldwi yralvllvia cpcalvistp vtivsglsaa arlgilikgg 421 vflelgrkls wvaldktgti thgkpqqtdy lpiaeadgtd arllaaslaa rsdhpvsrav 481 anaaeedgla lgvvedlaal pgrgvsgrid gvlyhlgnhr lveelglcsp aleerldale 541 rqgktvialc dpqrvralfa vadgvkdssr eaihelhald vktlmltgdn phtaaaiaaq 601 vgidaargnl lpedklreve arqadgsrvg mvgdgindap alaradigfa mgaagtdtai 661 etagvalmdd dlrklpqfvr lsrtthailv qnitlalgik avflaltlag egtlwmavfa 721 dmgasllvvf nglrllrkrf