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LOCUS WP_010895656 783 aa linear BCT 24-DEC-2024 [Pseudomonas aeruginosa]. ACCESSION WP_010895656 VERSION WP_010895656.1 KEYWORDS RefSeq. SOURCE Pseudomonas aeruginosa ORGANISM Pseudomonas aeruginosa Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas. REFERENCE 1 (residues 1 to 783) AUTHORS Romling,U. and Amikam,D. TITLE Cyclic di-GMP as a second messenger JOURNAL Curr Opin Microbiol 9 (2), 218-228 (2006) PUBMED 16530465 REFERENCE 2 (residues 1 to 783) AUTHORS Romling,U., Gomelsky,M. and Galperin,M.Y. TITLE C-di-GMP: the dawning of a novel bacterial signalling system JOURNAL Mol Microbiol 57 (3), 629-639 (2005) PUBMED 16045609 REFERENCE 3 (residues 1 to 783) AUTHORS Simm,R., Morr,M., Kader,A., Nimtz,M. and Romling,U. TITLE GGDEF and EAL domains inversely regulate cyclic di-GMP levels and transition from sessility to motility JOURNAL Mol Microbiol 53 (4), 1123-1134 (2004) PUBMED 15306016 REFERENCE 4 (residues 1 to 783) AUTHORS Galperin,M.Y., Nikolskaya,A.N. and Koonin,E.V. TITLE Novel domains of the prokaryotic two-component signal transduction systems JOURNAL FEMS Microbiol Lett 203 (1), 11-21 (2001) PUBMED 11557134 REMARK Erratum:[FEMS Microbiol Lett 2001 Oct 16;204(1):213-4] COMMENT REFSEQ: This record represents a single, non-redundant, protein sequence which may be annotated on many different RefSeq genomes from the same, or different, species. ##Evidence-For-Name-Assignment-START## Evidence Category :: Conserved Domain (CDD) Evidence Accession :: Domain architecture ID 11472025 Evidence Source :: NCBI SPARCLE ##Evidence-For-Name-Assignment-END## COMPLETENESS: full length. FEATURES Location/Qualifiers source 1..783 /organism="Pseudomonas aeruginosa" /db_xref="taxon:287" Protein 1..783 /product="putative bifunctional diguanylate cyclase/phosphodiesterase" /EC_number="2.7.7.65" /GO_component="GO:0005886 - plasma membrane [Evidence IEA]" /GO_function="GO:0005525 - GTP binding [Evidence IEA]" /GO_function="GO:0046872 - metal ion binding [Evidence IEA]" /GO_function="GO:0052621 - diguanylate cyclase activity [Evidence IEA]" /GO_function="GO:0071111 - cyclic-guanylate-specific phosphodiesterase activity [Evidence IEA]" /calculated_mol_wt=86686 Region 85..770 /region_name="COG5001" /note="Cyclic di-GMP metabolism protein, combines GGDEF and EAL domains with a 6TM membrane domain [Signal transduction mechanisms]" /db_xref="CDD:444025" ORIGIN 1 mpflpgkmpk pavcrrpats fhadlaggsr ylywkhnatp sphprrprvf rvqgdtamdw 61 qglrflgesp vdgyvlqnct yspslvalaf lvaclagyta ldmvervgns lshprlwqwi 121 gafclgsgiw athfvamlaf hapialrydl pitglsllia vaasyltmym tarprfgllp 181 cllaaccigl giaamhytgm aamrsvatqy yqpslfalsv liaigaafta laavpylrgr 241 rsaryrymkl iaslllagai aamhftgmaa lvlsvpagtp lelqasadsl rlgwltgvla 301 saiaacgiwa awsekqrerr lsensrvnal lnqldhahas lrqmarydsl tglqnrtafn 361 evfvqhlenc rlrgkglavm fldldhfkri ndslghdsgd qllkivseri rsvlrdsdvv 421 arfagdefcv ladltqdhea hilsqrlmqk mkepialdgr tlvmtasvgv slypndgeqc 481 eellknagla lhqskacgrn naqffsrqll vratqelqme eelrqalrdd qlelhyqpil 541 aladgevhql ealvrwrhpt qgllgpdrfi glaeangmid qlddwvlrra crdlrslhla 601 gherlrvavn ccasnlgras lvdevrhale qaglaacfle levtedalmy nidqtiplle 661 rlrelgvsls iddfgtgyss laylrrlpld alkvdrsfim dipasqrdme iaqaiiamaq 721 klhlkvvaeg vetpqqlafl renhcelvqg ylfsrplpla aleeflrayr fdaapplrsl 781 nqa