hybrid sensor histidine kinase/response regulator [Pseudomonas

LOCUS       WP_010895602             699 aa            linear   BCT 18-FEB-2025
            aeruginosa].
ACCESSION   WP_010895602
VERSION     WP_010895602.1
KEYWORDS    RefSeq.
SOURCE      Pseudomonas aeruginosa
  ORGANISM  Pseudomonas aeruginosa
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Pseudomonadales; Pseudomonadaceae; Pseudomonas.
REFERENCE   1  (residues 1 to 699)
  AUTHORS   Gao,R., Bouillet,S. and Stock,A.M.
  TITLE     Structural Basis of Response Regulator Function
  JOURNAL   Annu Rev Microbiol 73, 175-197 (2019)
   PUBMED   31100988
REFERENCE   2  (residues 1 to 699)
  AUTHORS   Galperin,M.Y.
  TITLE     Diversity of structure and function of response regulator output
            domains
  JOURNAL   Curr Opin Microbiol 13 (2), 150-159 (2010)
   PUBMED   20226724
REFERENCE   3  (residues 1 to 699)
  AUTHORS   Galperin,M.Y.
  TITLE     Structural classification of bacterial response regulators:
            diversity of output domains and domain combinations
  JOURNAL   J Bacteriol 188 (12), 4169-4182 (2006)
   PUBMED   16740923
REFERENCE   4  (residues 1 to 699)
  AUTHORS   Hefti,M.H., Francoijs,K.J., de Vries,S.C., Dixon,R. and Vervoort,J.
  TITLE     The PAS fold. A redefinition of the PAS domain based upon
            structural prediction
  JOURNAL   Eur J Biochem 271 (6), 1198-1208 (2004)
   PUBMED   15009198
REFERENCE   5  (residues 1 to 699)
  AUTHORS   Dutta,R. and Inouye,M.
  TITLE     GHKL, an emergent ATPase/kinase superfamily
  JOURNAL   Trends Biochem Sci 25 (1), 24-28 (2000)
   PUBMED   10637609
REFERENCE   6  (residues 1 to 699)
  AUTHORS   Stock,J.
  TITLE     Signal transduction: Gyrating protein kinases
  JOURNAL   Curr Biol 9 (10), R364-R367 (1999)
   PUBMED   10339418
REFERENCE   7  (residues 1 to 699)
  AUTHORS   Ponting,C.P. and Aravind,L.
  TITLE     PAS: a multifunctional domain family comes to light
  JOURNAL   Curr Biol 7 (11), R674-R677 (1997)
   PUBMED   9382818
REFERENCE   8  (residues 1 to 699)
  AUTHORS   Alex,L.A. and Simon,M.I.
  TITLE     Protein histidine kinases and signal transduction in prokaryotes
            and eukaryotes
  JOURNAL   Trends Genet 10 (4), 133-138 (1994)
   PUBMED   8029829
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 12815806
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..699
                     /organism="Pseudomonas aeruginosa"
                     /db_xref="taxon:287"
     Protein         1..699
                     /product="hybrid sensor histidine kinase/response
                     regulator"
                     /EC_number="2.7.13.3"
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /calculated_mol_wt=76377
     Region          62..315
                     /region_name="PAS"
                     /note="PAS domain [Signal transduction mechanisms];
                     COG2202"
                     /db_xref="CDD:441804"
     Region          224..688
                     /region_name="PRK13557"
                     /note="histidine kinase; Provisional"
                     /db_xref="CDD:237425"
ORIGIN      
        1 mefagragvf rkvgqvpgas qraagrrssy ylagcalqpg sssrrvntsm kttrkpkvpl
       61 nqatrnrlld eavddyaiht ldsaghiasw sagaarlfgh daseilgrdy acfhtrkdrd
      121 agvpqqalrq adaegrfete gwrvrsngkr fwaqvvidai rdsqgqllgf aqlihdlseg
      181 raakealrrs qeqfrllvqs vtdyaiymld hrgritnwnl gaqrikgylp eevigrhfsc
      241 fytpedreag eparglaaae regrfekegw rvrkdgsrfw anvvidpird sdgrligfak
      301 vtrdithrie aerelerarq elfqaqkmes lghltggvah dfnnlltvii gslgllkkrl
      361 pgdqrtadll qnaleaaqrg anltqrmlsf arkqrldpqp caipdllrgm tdllihslgp
      421 svsietrfpl dldlgltdan qlelsiinla tnardampng grivfsasnq rvpadnphrl
      481 apgnyiclsi sdtgsgmdee tlrravepfy ttkgigrgtg lglsivdgla eqlggrltle
      541 sqpgvgttan iwipavprtp esartgngat pqppseserv rlscrvlvvd ddplvlnnta
      601 amledlgcsv lkadsgslal eiltatpeld illtdqampr mngsqlverv maqgrplkma
      661 latgfaekie gaaaqlpkla kpfgqeelyl fltgtlkag