MATE family efflux transporter [Listeria monocytogenes].

LOCUS       WP_009930806             450 aa            linear   BCT 31-DEC-2024
ACCESSION   WP_009930806
VERSION     WP_009930806.1
KEYWORDS    RefSeq.
SOURCE      Listeria monocytogenes
  ORGANISM  Listeria monocytogenes
            Bacteria; Bacillati; Bacillota; Bacilli; Bacillales; Listeriaceae;
            Listeria.
REFERENCE   1  (residues 1 to 450)
  AUTHORS   Claxton,D.P., Jagessar,K.L. and Mchaourab,H.S.
  TITLE     Principles of Alternating Access in Multidrug and Toxin Extrusion
            (MATE) Transporters
  JOURNAL   J Mol Biol 433 (16), 166959 (2021)
   PUBMED   33774036
REFERENCE   2  (residues 1 to 450)
  AUTHORS   Kusakizako,T., Miyauchi,H., Ishitani,R. and Nureki,O.
  TITLE     Structural biology of the multidrug and toxic compound extrusion
            superfamily transporters
  JOURNAL   Biochim Biophys Acta Biomembr 1862 (12), 183154 (2020)
   PUBMED   31866287
REFERENCE   3  (residues 1 to 450)
  AUTHORS   Radchenko,M., Symersky,J., Nie,R. and Lu,M.
  TITLE     Structural basis for the blockade of MATE multidrug efflux pumps
  JOURNAL   Nat Commun 6, 7995 (2015)
   PUBMED   26246409
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 450)
  AUTHORS   Kaatz,G.W., DeMarco,C.E. and Seo,S.M.
  TITLE     MepR, a repressor of the Staphylococcus aureus MATE family
            multidrug efflux pump MepA, is a substrate-responsive regulatory
            protein
  JOURNAL   Antimicrob Agents Chemother 50 (4), 1276-1281 (2006)
   PUBMED   16569840
REFERENCE   5  (residues 1 to 450)
  AUTHORS   Putman,M., van Veen,H.W. and Konings,W.N.
  TITLE     Molecular properties of bacterial multidrug transporters
  JOURNAL   Microbiol Mol Biol Rev 64 (4), 672-693 (2000)
   PUBMED   11104814
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 10192113
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..450
                     /organism="Listeria monocytogenes"
                     /db_xref="taxon:1639"
     Protein         1..450
                     /product="MATE family efflux transporter"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0015297 - antiporter activity [Evidence
                     IEA]"
                     /GO_function="GO:0042910 - xenobiotic transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:0006855 - xenobiotic transmembrane
                     transport [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport
                     [Evidence IEA]"
                     /calculated_mol_wt=48691
     Region          12..436
                     /region_name="MATE_MepA_like"
                     /note="Subfamily of the multidrug and toxic compound
                     extrusion (MATE)-like proteins similar to Streptococcus
                     aureus MepA; cd13143"
                     /db_xref="CDD:240548"
ORIGIN      
        1 mkeqskrlge dsipslmarl sipafigmfv mgmynivdti fvsygvgpsg vaalsiafpv
       61 qmilmamaam fgiggasiis rslgageqkh adkvfhqviw lvlissifia ivtfifldpl
      121 itlfgapadi hdiasdflsl illgavfqtf amamnnivrs egnaktamlt miisailnmi
      181 lnpifimgfg mgvrgsalat viaqavgaiw lliyflsgks tlslkgfsfr mdfplirrim
      241 aigfpsfimm sagsivtvav nwmlniyggt maiavygian riasfvimpi ngvtqgmqpi
      301 vgfnygsrqf ervmkavkvs miaatvmsli awglveifpg llvrifsndp eliaqgttav
      361 rfmllaapti gfqivcggly qalgrarisf iislmrqiic lvplllilph ffgldgiwya
      421 fpladlgafa vclvimsktw rrifknpeiv