histidinol dehydrogenase [Listeria monocytogenes].

LOCUS       WP_009930740             427 aa            linear   BCT 17-JUN-2024
ACCESSION   WP_009930740
VERSION     WP_009930740.1
KEYWORDS    RefSeq.
SOURCE      Listeria monocytogenes
  ORGANISM  Listeria monocytogenes
            Bacteria; Bacillati; Bacillota; Bacilli; Bacillales; Listeriaceae;
            Listeria.
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: TIGR00069.1
            Evidence Source    :: JCVI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..427
                     /organism="Listeria monocytogenes"
                     /db_xref="taxon:1639"
     gene            1..427
                     /gene="hisD"
     Protein         1..427
                     /product="histidinol dehydrogenase"
                     /EC_number="1.1.1.23"
                     /GO_function="GO:0004399 - histidinol dehydrogenase
                     activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0051287 - NAD binding [Evidence IEA]"
                     /GO_process="GO:0000105 - histidine biosynthetic process
                     [Evidence IEA]"
                     /calculated_mol_wt=46099
     Region          1..423
                     /region_name="hisD"
                     /note="bifunctional histidinal dehydrogenase/ histidinol
                     dehydrogenase; Reviewed; PRK00877"
                     /db_xref="CDD:234853"
     Site            order(53,125,127..128,136,157,183..184,186,207..209,
                     211..212,257)
                     /site_type="other"
                     /note="NAD binding site [chemical binding]"
                     /db_xref="CDD:119329"
     Site            order(78..79,82..83,85,88..89,92..93,96..97,104,106,
                     110..114,117,119,131..135,202,217,221,245..246,249..250,
                     252..254,256..257,327,332,335..336,338..346,348,350..351,
                     353..357,359,361,371..372,374..378,380..381,384..391,
                     406..407,409..415)
                     /site_type="other"
                     /note="dimerization interface [polypeptide binding]"
                     /db_xref="CDD:119329"
     Site            order(133,135,232,257,322..323,352,356..357,363,410,412,
                     415)
                     /site_type="active"
                     /note="product binding site [active]"
                     /db_xref="CDD:119329"
     Site            order(135,232,254,257,322..323,352,356..357,363,410,412,
                     415)
                     /site_type="other"
                     /note="substrate binding site [chemical binding]"
                     /db_xref="CDD:119329"
     Site            order(254,257,356,415)
                     /site_type="other"
                     /note="zinc binding site [ion binding]"
                     /db_xref="CDD:119329"
     Site            322..323
                     /site_type="active"
                     /note="catalytic residues [active]"
                     /db_xref="CDD:119329"
ORIGIN      
        1 mkiltgtine llnevkaenn tnnslqvese vksiiekvkk dgdqalfdft sqfdgvrlte
       61 lrvqtadiqs asskvdpafl valqqakani esfhskqkqh afldsekdgv irgqlirple
      121 tvgiyvpggt aaypssvlmn vlpakiagvk rivmitppae nginphvlaa aqlagvdeiy
      181 qvggahgiaa lahgtesipk vdkivgpgni yvatakrevf glvdidmiag pseivvlade
      241 nanpafiasd llsqaehdil arailittsk kiaeetqnei nkqlenlprk aiaqksietq
      301 gkiiiaantq emfdimneia pehlevqlen pmnylnqikn agsiflgsya seplgdyfag
      361 pnhvlptsgt akffsplgve dftkrsafis ytkealakek daivllakke gldahakaiq
      421 irfeeen