MATE family efflux transporter [Listeria monocytogenes].

LOCUS       WP_009925931             453 aa            linear   BCT 01-JAN-2025
ACCESSION   WP_009925931
VERSION     WP_009925931.1
KEYWORDS    RefSeq.
SOURCE      Listeria monocytogenes
  ORGANISM  Listeria monocytogenes
            Bacteria; Bacillati; Bacillota; Bacilli; Bacillales; Listeriaceae;
            Listeria.
REFERENCE   1  (residues 1 to 453)
  AUTHORS   Claxton,D.P., Jagessar,K.L. and Mchaourab,H.S.
  TITLE     Principles of Alternating Access in Multidrug and Toxin Extrusion
            (MATE) Transporters
  JOURNAL   J Mol Biol 433 (16), 166959 (2021)
   PUBMED   33774036
REFERENCE   2  (residues 1 to 453)
  AUTHORS   Kusakizako,T., Miyauchi,H., Ishitani,R. and Nureki,O.
  TITLE     Structural biology of the multidrug and toxic compound extrusion
            superfamily transporters
  JOURNAL   Biochim Biophys Acta Biomembr 1862 (12), 183154 (2020)
   PUBMED   31866287
REFERENCE   3  (residues 1 to 453)
  AUTHORS   Radchenko,M., Symersky,J., Nie,R. and Lu,M.
  TITLE     Structural basis for the blockade of MATE multidrug efflux pumps
  JOURNAL   Nat Commun 6, 7995 (2015)
   PUBMED   26246409
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 453)
  AUTHORS   Kaatz,G.W., DeMarco,C.E. and Seo,S.M.
  TITLE     MepR, a repressor of the Staphylococcus aureus MATE family
            multidrug efflux pump MepA, is a substrate-responsive regulatory
            protein
  JOURNAL   Antimicrob Agents Chemother 50 (4), 1276-1281 (2006)
   PUBMED   16569840
REFERENCE   5  (residues 1 to 453)
  AUTHORS   Putman,M., van Veen,H.W. and Konings,W.N.
  TITLE     Molecular properties of bacterial multidrug transporters
  JOURNAL   Microbiol Mol Biol Rev 64 (4), 672-693 (2000)
   PUBMED   11104814
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 10192113
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..453
                     /organism="Listeria monocytogenes"
                     /db_xref="taxon:1639"
     Protein         1..453
                     /product="MATE family efflux transporter"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0015297 - antiporter activity [Evidence
                     IEA]"
                     /GO_function="GO:0042910 - xenobiotic transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:0006855 - xenobiotic transmembrane
                     transport [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport
                     [Evidence IEA]"
                     /calculated_mol_wt=49158
     Region          13..435
                     /region_name="MATE_MepA_like"
                     /note="Subfamily of the multidrug and toxic compound
                     extrusion (MATE)-like proteins similar to Streptococcus
                     aureus MepA; cd13143"
                     /db_xref="CDD:240548"
ORIGIN      
        1 mkhsdnyylt kasipkaiah lsipmmlgms vgviynivna ffigllhdts mltavtlglp
       61 mftilmaign mfgvgggtyi srllgkeegt kakqvsafvl ygslvlgilc aillgflinp
      121 vthflgadat sflhtknytl allicspfii anfaleqvvr aegasrvsmn gmligtvvnl
      181 vfdpllilyf dfnvvgaavs vglaslfsli yyawylekks dylsirfkwf qaskeivqnv
      241 fkigvselll slflivttlv lnhysmiyge gvvagfgval rvvqlpefic mglymgiipl
      301 laynygsgni arfekairft aisiglivll lsslvfifrf qvmhlfsdsq svitlgvhim
      361 vamlisslfs gftglftstf qaigkaipat imsvsqgiif ipviilgqhy fglmgviwsl
      421 tateiltcii gvtlftihni kiassaktkd lav