MULTISPECIES: MATE family efflux transporter [Vibrio].

LOCUS       WP_009706068             456 aa            linear   BCT 21-MAR-2023
ACCESSION   WP_009706068
VERSION     WP_009706068.1
KEYWORDS    RefSeq.
SOURCE      Vibrio
  ORGANISM  Vibrio
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Vibrionales; Vibrionaceae.
REFERENCE   1  (residues 1 to 456)
  AUTHORS   Claxton,D.P., Jagessar,K.L. and Mchaourab,H.S.
  TITLE     Principles of Alternating Access in Multidrug and Toxin Extrusion
            (MATE) Transporters
  JOURNAL   J Mol Biol 433 (16), 166959 (2021)
   PUBMED   33774036
REFERENCE   2  (residues 1 to 456)
  AUTHORS   Kusakizako,T., Miyauchi,H., Ishitani,R. and Nureki,O.
  TITLE     Structural biology of the multidrug and toxic compound extrusion
            superfamily transporters
  JOURNAL   Biochim Biophys Acta Biomembr 1862 (12), 183154 (2020)
   PUBMED   31866287
REFERENCE   3  (residues 1 to 456)
  AUTHORS   Radchenko,M., Symersky,J., Nie,R. and Lu,M.
  TITLE     Structural basis for the blockade of MATE multidrug efflux pumps
  JOURNAL   Nat Commun 6, 7995 (2015)
   PUBMED   26246409
  REMARK    Publication Status: Online-Only
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 11479710
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..456
                     /organism="Vibrio"
                     /db_xref="taxon:662"
     Protein         1..456
                     /product="MATE family efflux transporter"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0042910 - xenobiotic transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:0006855 - xenobiotic transmembrane
                     transport [Evidence IEA]"
                     /calculated_mol_wt=49180
     Region          1..454
                     /region_name="PRK01766"
                     /note="multidrug efflux protein; Reviewed"
                     /db_xref="CDD:234981"
     Site            order(251,255,281,284,363,367,394,424,428)
                     /site_type="other"
                     /note="cation binding site [ion binding]"
                     /db_xref="CDD:240536"
ORIGIN      
        1 mhrykeeass liklatpvli asvaqtgmgf vdtvmaggvs atdmaavsva asiwlpsilf
       61 gvgllmalvp vvaqlngsgr rvkipfeiqq givlallisi piigvlfqtq filglmdvea
      121 amtektigyi havifavpaf llfqtlrsft dgmsltkpam figfiglmln iplnwifvyg
      181 kfgapalggv gcgvataivy wvmfglllly vttsarlksi nlfgefhkpq lkaqirlfkl
      241 gfpvaaalff evtlfavval lvsplgsiiv aahqvainfs slvfmlpmsv gaavsirvgh
      301 rlgeenvdga rvasrvgvmv glalammtai ltvvfreqia llytnnpevi elamvlllfa
      361 aiyqctdavq viaagalrgy kdmraifnrt fiaywllglp igyvlgrtdw ivepmgaqgf
      421 wlgfiiglss aafllgirlr wmhrqdpevq lnfsqq