MULTISPECIES: bifunctional UDP-sugar hydrolase/5'-nucleotidase UshA

LOCUS       WP_009388284             553 aa            linear   BCT 14-DEC-2022
            [Vibrio].
ACCESSION   WP_009388284
VERSION     WP_009388284.1
KEYWORDS    RefSeq.
SOURCE      Vibrio
  ORGANISM  Vibrio
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Vibrionales; Vibrionaceae.
REFERENCE   1  (residues 1 to 553)
  AUTHORS   Krug,U., Patzschke,R., Zebisch,M., Balbach,J. and Strater,N.
  TITLE     Contribution of the two domains of E. coli 5'-nucleotidase to
            substrate specificity and catalysis
  JOURNAL   FEBS Lett 587 (5), 460-466 (2013)
   PUBMED   23333297
REFERENCE   2  (residues 1 to 553)
  AUTHORS   Alves-Pereira,I., Canales,J., Cabezas,A., Cordero,P.M., Costas,M.J.
            and Cameselle,J.C.
  TITLE     CDP-alcohol hydrolase, a very efficient activity of the
            5'-nucleotidase/UDP-sugar hydrolase encoded by the ushA gene of
            Yersinia intermedia and Escherichia coli
  JOURNAL   J Bacteriol 190 (18), 6153-6161 (2008)
   PUBMED   18641143
REFERENCE   3  (residues 1 to 553)
  AUTHORS   Knofel,T. and Strater,N.
  TITLE     X-ray structure of the Escherichia coli periplasmic 5'-nucleotidase
            containing a dimetal catalytic site
  JOURNAL   Nat Struct Biol 6 (5), 448-453 (1999)
   PUBMED   10331872
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: NF007109.1
            Evidence Source    :: NCBI Protein Cluster (PRK)
            Source Identifier  :: PRK09558
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..553
                     /organism="Vibrio"
                     /db_xref="taxon:662"
     gene            1..553
                     /gene="ushA"
     Protein         1..553
                     /product="bifunctional UDP-sugar hydrolase/5'-nucleotidase
                     UshA"
                     /EC_number="3.1.3.5"
                     /EC_number="3.6.1.45"
                     /GO_function="GO:0000166 - nucleotide binding [Evidence
                     IEA]"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0009166 - nucleotide catabolic process
                     [Evidence IEA]"
                     /calculated_mol_wt=61042
     Region          3..553
                     /region_name="ushA"
                     /note="bifunctional UDP-sugar hydrolase/5'-nucleotidase
                     periplasmic precursor; Reviewed; PRK09558"
                     /db_xref="CDD:236566"
ORIGIN      
        1 mkqrlivkta lsaailatla gcatapqqew eadktykltv lhtndnhgrf wenkygeygm
       61 aarktlidql raevqadggs vlllsggdin tgvpesdlqd aepdfkgmnk igydamalgn
      121 hefdnplevl fkqeewanfp mlsaniydkk tgermfqayq mfnkqgikia viglttedtq
      181 kignpeyigg lefrdpkaea kkliaeleqt ekpdlifavt hmghyedgnr ginapgdval
      241 aryldegsld mivgghsqep vcmeapnvmk knfqpsdeck pdvqngtyiv qahewgkyvg
      301 radyefrnge lnmvsydlip vnlkkkikvd geskrvfied eiakdealle flrpfqeegq
      361 dklnvkiaet ngklegdrnv vrfeqtnlgr liaashmera qadfavmnsg gvrdsiaagn
      421 vtykdvltvq pfgnivtyid msgkevldyl nvvgtkpvds gayvqfygvs mtvadgkvsd
      481 vklggeavel ektyrftvps ynaaggdgyp kvsdhpgyvn tgfvdaevlk efleanspvd
      541 vnkfapkgei vyk