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aminopeptidase P family protein [Photobacterium sp. SKA34].


LOCUS       WP_006643460             595 aa            linear   BCT 21-MAR-2023
ACCESSION   WP_006643460
VERSION     WP_006643460.1
KEYWORDS    RefSeq.
SOURCE      Photobacterium sp. SKA34
  ORGANISM  Photobacterium sp. SKA34
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Vibrionales; Vibrionaceae; Photobacterium.
REFERENCE   1  (residues 1 to 595)
  AUTHORS   Are,V.N., Kumar,A., Goyal,V.D., Gotad,S.S., Ghosh,B., Gadre,R.,
            Jamdar,S.N. and Makde,R.D.
  TITLE     Structures and activities of widely conserved small prokaryotic
            aminopeptidases-P clarify classification of M24B peptidases
  JOURNAL   Proteins 87 (3), 212-225 (2019)
   PUBMED   30536999
REFERENCE   2  (residues 1 to 595)
  AUTHORS   Graham,S.C., Bond,C.S., Freeman,H.C. and Guss,J.M.
  TITLE     Structural and functional implications of metal ion selection in
            aminopeptidase P, a metalloprotease with a dinuclear metal center
  JOURNAL   Biochemistry 44 (42), 13820-13836 (2005)
   PUBMED   16229471
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 11114206
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..595
                     /organism="Photobacterium sp. SKA34"
                     /db_xref="taxon:121723"
     Protein         1..595
                     /product="aminopeptidase P family protein"
                     /EC_number="3.4.11.-"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0004177 - aminopeptidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0070006 - metalloaminopeptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /calculated_mol_wt=65219
     Region          8..145
                     /region_name="Creatinase_N"
                     /note="Creatinase/Prolidase N-terminal domain; pfam01321"
                     /db_xref="CDD:460159"
     Region          148..306
                     /region_name="Creatinase_N_2"
                     /note="Creatinase/Prolidase N-terminal domain; pfam16189"
                     /db_xref="CDD:465053"
     Region          309..531
                     /region_name="APP"
                     /note="X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also
                     known as X-Pro aminopeptidase, proline aminopeptidase,
                     aminopeptidase P, and aminoacylproline aminopeptidase.
                     Catalyses release of any N-terminal amino acid, including
                     proline, that is linked with proline; cd01085"
                     /db_xref="CDD:238518"
     Site            order(376,397,408,475,504,518)
                     /site_type="active"
                     /db_xref="CDD:238518"
     Region          535..593
                     /region_name="Peptidase_M24_C"
                     /note="C-terminal region of peptidase_M24; pfam16188"
                     /db_xref="CDD:465052"
ORIGIN      
        1 mqaviaqrie qirqwleaqq ldalliphed eylgeyipdh nerlhwltgf tgsagaavit
       61 rdraamfvdg ryvvqvrkqv pgdvfeychl ieqppvhwvl enlaagskva idnrlhsaaw
      121 lknvtttldg elelvsvnen pidelwldrp apklsdaelm gleyvgqsse ekreqiaall
      181 kkqkadaafl sqldsiawll nvrgddvhcl pvllsaavih sdasvdfyid hhrlpegfat
      241 hvgngvnire peqlaaglaa lsgkrvqfds ansnawaaqq ltdagaqlie aanptllpka
      301 akntteingm kachirdgva iskflawvdn qvasgnllne aelsdqlwqf rqqdpscrdv
      361 sfdtisasag naamchynhi dqpqpgklqm dtvylvdsgg qypdgttdit rtiaignpgn
      421 evkqaftlvl kghislasar fpkgttgsql dalarqhlwa hgfdydhgtg hgvghflsvh
      481 egpqriskva nptallpgmv lsnepgyyra dafgirienl elvvdietqg dmnvmgfesl
      541 trapidkrli dpalltdvel awlnnyhqtv fnvislsltg sdlewltqat splsr