bifunctional phosphopantothenoylcysteine

LOCUS       WP_005501510             407 aa            linear   BCT 17-JUN-2024
            decarboxylase/phosphopantothenate--cysteine ligase CoaBC [Grimontia
            hollisae].
ACCESSION   WP_005501510
VERSION     WP_005501510.1
KEYWORDS    RefSeq.
SOURCE      Grimontia hollisae
  ORGANISM  Grimontia hollisae
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Vibrionales; Vibrionaceae; Grimontia.
REFERENCE   1  (residues 1 to 407)
  AUTHORS   Strauss,E., Kinsland,C., Ge,Y., McLafferty,F.W. and Begley,T.P.
  TITLE     Phosphopantothenoylcysteine synthetase from Escherichia coli.
            Identification and characterization of the last unidentified
            coenzyme A biosynthetic enzyme in bacteria
  JOURNAL   J Biol Chem 276 (17), 13513-13516 (2001)
   PUBMED   11278255
REFERENCE   2  (residues 1 to 407)
  AUTHORS   Spitzer,E.D., Jimenez-Billini,H.E. and Weiss,B.
  TITLE     beta-Alanine auxotrophy associated with dfp, a locus affecting DNA
            synthesis in Escherichia coli
  JOURNAL   J Bacteriol 170 (2), 872-876 (1988)
   PUBMED   3123465
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: TIGR00521.1
            Evidence Source    :: JCVI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..407
                     /organism="Grimontia hollisae"
                     /db_xref="taxon:673"
     gene            1..407
                     /gene="coaBC"
     Protein         1..407
                     /product="bifunctional phosphopantothenoylcysteine
                     decarboxylase/phosphopantothenate--cysteine ligase CoaBC"
                     /EC_number="4.1.1.36"
                     /EC_number="6.3.2.5"
                     /GO_function="GO:0004632 - phosphopantothenate--cysteine
                     ligase activity [Evidence IEA]"
                     /GO_function="GO:0004633 - phosphopantothenoylcysteine
                     decarboxylase activity [Evidence IEA]"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /GO_process="GO:0015937 - coenzyme A biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0015941 - pantothenate catabolic process
                     [Evidence IEA]"
                     /calculated_mol_wt=43150
     Region          9..406
                     /region_name="CoaBC"
                     /note="Phosphopantothenoylcysteine
                     synthetase/decarboxylase CoaBC [Coenzyme transport and
                     metabolism]; COG0452"
                     /db_xref="CDD:440221"
ORIGIN      
        1 maqkitqtls gkhivlgigg giaaykcadl trrliergae vrivmthaak efitpltmqa
       61 vsgypvadsl ldpaaeasmg hieiakwadl vllapatadl iarvaagmgn dllttlclat
      121 dapvalapam nqqmyravat qenlatlkrr ghpvwgpasg eqacgdvgpg rmlepmqlvg
      181 lieehftegd lsgtsflita gptreaidpv ryltnhssgk mgyaiaeaaa krgatvtlis
      241 gpvnlptpag vsridvesaq qmhdavhaha gqhqifiaca avadfrpani adqkmkkqdg
      301 qddmtltlvk npdivasvaa mtenrpftvg faaetqdieh yarnklakkn ldlicandvs
      361 regqgfnsdq nalhlywptg dkalplaska dighqlvsei talyhsk