diguanylate cyclase DosC [Shigella flexneri].

LOCUS       WP_005062918             381 aa            linear   BCT 03-JUL-2022
ACCESSION   WP_005062918
VERSION     WP_005062918.1
KEYWORDS    RefSeq.
SOURCE      Shigella flexneri
  ORGANISM  Shigella flexneri
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Shigella.
REFERENCE   1  (residues 1 to 381)
  AUTHORS   Kitanishi,K., Kobayashi,K., Kawamura,Y., Ishigami,I., Ogura,T.,
            Nakajima,K., Igarashi,J., Tanaka,A. and Shimizu,T.
  TITLE     Important roles of Tyr43 at the putative heme distal side in the
            oxygen recognition and stability of the Fe(II)-O2 complex of YddV,
            a globin-coupled heme-based oxygen sensor diguanylate cyclase
  JOURNAL   Biochemistry 49 (49), 10381-10393 (2010)
   PUBMED   21067162
REFERENCE   2  (residues 1 to 381)
  AUTHORS   Tuckerman,J.R., Gonzalez,G., Sousa,E.H., Wan,X., Saito,J.A.,
            Alam,M. and Gilles-Gonzalez,M.A.
  TITLE     An oxygen-sensing diguanylate cyclase and phosphodiesterase couple
            for c-di-GMP control
  JOURNAL   Biochemistry 48 (41), 9764-9774 (2009)
   PUBMED   19764732
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: BlastRule
            Evidence Accession :: NBR007785
            Evidence Source    :: NCBI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..381
                     /organism="Shigella flexneri"
                     /db_xref="taxon:623"
     gene            1..381
                     /gene="dosC"
     Protein         1..381
                     /product="diguanylate cyclase DosC"
                     /EC_number="2.7.7.65"
                     /calculated_mol_wt=43866
     Region          7..153
                     /region_name="GS_EcDosC-like_GGDEF"
                     /note="Globin sensor domain of Escherichia coli Direct
                     Oxygen Sensing Cyclase and related proteins; coupled to a
                     C-terminal GGDEF domain; cd14757"
                     /db_xref="CDD:381271"
     Site            order(13..15,45,105..107,109..110,113,116,137..138,
                     141..142,145,149)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:381271"
     Site            order(52,55,65,68..69,72,94,97..98,103,107,111..112,151)
                     /site_type="other"
                     /note="heme binding site [chemical binding]"
                     /db_xref="CDD:381271"
     Region          185..>357
                     /region_name="GGDEF"
                     /note="GGDEF domain, diguanylate cyclase (c-di-GMP
                     synthetase) or its enzymatically inactive variants [Signal
                     transduction mechanisms]; COG2199"
                     /db_xref="CDD:441801"
     Region          297..>356
                     /region_name="Nucleotidyl_cyc_III"
                     /note="Class III nucleotidyl cyclases; cl11967"
                     /db_xref="CDD:448371"
ORIGIN      
        1 memyfkrmkd ewtglveqad plirakaaei alahahylsi efyrivridp haeeflsneq
       61 verqlksame rwiinvlsaq vddverliqi qhtvaevhar igipveivem gfrvlkkily
      121 pvifssdysa aeklqvyhfs insidiamev mtraftfsds saskedenyr ifsllenaee
      181 ekerqiasil sweidiiykv lldsdlgssl plsqadfglw fnhkgrhyfs giaevghisr
      241 liqdfdgifn qtmrntriln nrslrvkfll qirntvsqii tllrelfeev srhevgmdvl
      301 tkllnrrflp tifkreiaha nrtgtplsvl iidvdkfkei ndtwghntgd eilrkvsfls
      361 qkrlvkskil gagssrklav s