bifunctional diaminohydroxyphosphoribosylaminopyrimidine

LOCUS       WP_004408448             365 aa            linear   BCT 28-FEB-2022
            deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD
            [Vibrio nigripulchritudo].
ACCESSION   WP_004408448
VERSION     WP_004408448.1
KEYWORDS    RefSeq.
SOURCE      Vibrio nigripulchritudo
  ORGANISM  Vibrio nigripulchritudo
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Vibrionales; Vibrionaceae; Vibrio.
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: TIGR00326.1
            Evidence Source    :: JCVI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..365
                     /organism="Vibrio nigripulchritudo"
                     /db_xref="taxon:28173"
     gene            1..365
                     /gene="ribD"
     Protein         1..365
                     /product="bifunctional
                     diaminohydroxyphosphoribosylaminopyrimidine
                     deaminase/5-amino-6-(5-phosphoribosylamino)uracil
                     reductase RibD"
                     /EC_number="1.1.1.193"
                     /EC_number="3.5.4.26"
                     /GO_function="GO:0008703 -
                     5-amino-6-(5-phosphoribosylamino)uracil reductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008835 -
                     diaminohydroxyphosphoribosylaminopyrimidine deaminase
                     activity [Evidence IEA]"
                     /calculated_mol_wt=39492
     Region          6..357
                     /region_name="DHFR"
                     /note="Dihydrofolate reductase (DHFR). Reduces
                     7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH
                     as a cofactor. This is an essential step in the
                     biosynthesis of deoxythymidine phosphate since
                     5,6,7,8-tetrahydrofolate is required to regenerate 5;
                     cl17279"
                     /db_xref="CDD:473077"
ORIGIN      
        1 mrsteldhqm maraialakr grfttspnpn vgcviakdgk ivgeglhfka gephaevhal
       61 raagenakga tayvtlepcs hygrtppcse alikagvarv vcamqdpnpv vagrgvkmlr
      121 dagvevevgv lesdaralnk gflkrmetgk pfvqlklaas ldgqtalsng eskwitspqa
      181 rqdvqayraq scaivstskt viddnaslnv rwselpestq viypeselrq parvildrqq
      241 klhqnlslfq tpgnievvdp kspyfqlnsa gqvdipyvfd klaeklgiqh iwveagatla
      301 aslieqdlmd elivylapkl mgsdgrglvh ilgltsmqqa idleindvrm vgpdiritak
      361 viknt