Unfortunately due to lack of commercial feasibility, the SkyBLAST service has been suspended from December 1st, 2025.
All subscriptions for paid accounts have been paused. For further information or enquiries, please email [email protected]
LOCUS WP_004229436 333 aa linear BCT 20-NOV-2023 [Klebsiella]. ACCESSION WP_004229436 VERSION WP_004229436.1 KEYWORDS RefSeq. SOURCE Klebsiella ORGANISM Klebsiella Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group. REFERENCE 1 (residues 1 to 333) AUTHORS Bondos,S.E., Swint-Kruse,L. and Matthews,K.S. TITLE Flexibility and Disorder in Gene Regulation: LacI/GalR and Hox Proteins JOURNAL J Biol Chem 290 (41), 24669-24677 (2015) PUBMED 26342073 REFERENCE 2 (residues 1 to 333) AUTHORS Swint-Kruse,L. and Matthews,K.S. TITLE Allostery in the LacI/GalR family: variations on a theme JOURNAL Curr Opin Microbiol 12 (2), 129-137 (2009) PUBMED 19269243 COMMENT REFSEQ: This record represents a single, non-redundant, protein sequence which may be annotated on many different RefSeq genomes from the same, or different, species. ##Evidence-For-Name-Assignment-START## Evidence Category :: Conserved Domain (CDD) Evidence Accession :: Domain architecture ID 11265705 Evidence Source :: NCBI SPARCLE ##Evidence-For-Name-Assignment-END## COMPLETENESS: full length. FEATURES Location/Qualifiers source 1..333 /organism="Klebsiella" /db_xref="taxon:570" Protein 1..333 /product="LacI family DNA-binding transcriptional regulator" /GO_function="GO:0000976 - transcription cis-regulatory region binding [Evidence IEA]" /GO_function="GO:0003700 - DNA-binding transcription factor activity [Evidence IEA]" /GO_function="GO:0043565 - sequence-specific DNA binding [Evidence IEA]" /GO_process="GO:0006351 - DNA-templated transcription [Evidence IEA]" /GO_process="GO:0006355 - regulation of DNA-templated transcription [Evidence IEA]" /GO_process="GO:0045892 - negative regulation of DNA-templated transcription [Evidence IEA]" /calculated_mol_wt=36965 Region 1..67 /region_name="HTH_LACI" /note="helix_turn _helix lactose operon repressor; smart00354" /db_xref="CDD:197675" Site order(10..14,16..17,20,25..26,29,42,45,48..49,51..52) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:143331" Site 42..51 /site_type="active" /note="domain linker motif [active]" /db_xref="CDD:143331" Region 58..324 /region_name="PBP1_GalS-like" /note="ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; cd06270" /db_xref="CDD:380494" Site order(58,65,71,76,79,88..91,93,107,111,219..220,252, 278..279) /site_type="other" /note="dimer interface (closed form) [polypeptide binding]" /db_xref="CDD:380494" Site order(70,119,192,217,243,271) /site_type="other" /note="ligand binding site [chemical binding]" /db_xref="CDD:380494" ORIGIN 1 mldvsiragv skatvsrvln gtgqvkestr qqvfkameel gyrpnflars lanqtsnsig 61 lvvstfdgfy fgrllqqasr qteawgkqli vtdghdtper eeeavqmlad rqcdaiilyt 121 rhmsekaims linsiamplv vinrdvaqar ercvffeqqe aafqaveyli tqghrdiaci 181 tvpmhtptgq arlqgyrnal ikhgiewdps rvkygdstmt rgyelcrell dekarfsalf 241 scnddmalga skalhqaglr ipqdvslfgf ddapsakwle pglstvylpi dnmittaidq 301 aiklanqqpi etippftgtl vlresvttgp ffk