MFS transporter [Klebsiella pneumoniae].

LOCUS       WP_004227116             473 aa            linear   BCT 01-JAN-2025
ACCESSION   WP_004227116
VERSION     WP_004227116.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella pneumoniae
  ORGANISM  Klebsiella pneumoniae
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group;
            Klebsiella; Klebsiella pneumoniae complex.
REFERENCE   1  (residues 1 to 473)
  AUTHORS   Quistgaard,E.M., Low,C., Guettou,F. and Nordlund,P.
  TITLE     Understanding transport by the major facilitator superfamily (MFS):
            structures pave the way
  JOURNAL   Nat Rev Mol Cell Biol 17 (2), 123-132 (2016)
   PUBMED   26758938
REFERENCE   2  (residues 1 to 473)
  AUTHORS   Zhang,X.C., Zhao,Y., Heng,J. and Jiang,D.
  TITLE     Energy coupling mechanisms of MFS transporters
  JOURNAL   Protein Sci 24 (10), 1560-1579 (2015)
   PUBMED   26234418
REFERENCE   3  (residues 1 to 473)
  AUTHORS   Yan,N.
  TITLE     Structural Biology of the Major Facilitator Superfamily
            Transporters
  JOURNAL   Annu Rev Biophys 44, 257-283 (2015)
   PUBMED   26098515
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 13022956
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..473
                     /organism="Klebsiella pneumoniae"
                     /db_xref="taxon:573"
     Protein         1..473
                     /product="MFS transporter"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport
                     [Evidence IEA]"
                     /calculated_mol_wt=49745
     Region          38..468
                     /region_name="MFS_MMR_MDR_like"
                     /note="Methylenomycin A resistance protein (also called
                     MMR peptide) and similar multidrug resistance (MDR)
                     transporters of the Major Facilitator Superfamily;
                     cd17321"
                     /db_xref="CDD:340879"
     Site            order(45..46,49..50,53,85,135..136,138..140,143,163,
                     166..167,170,294,297..298,301..303,306,334,338,390..391,
                     395,399,415,418..419,422..423,426)
                     /site_type="other"
                     /note="putative chemical substrate binding pocket
                     [chemical binding]"
                     /db_xref="CDD:340879"
ORIGIN      
        1 mlnssfkkpf hlrliftmdk nssdgvplpq rygailtivl gltmavldga ianvalptia
       61 sdlnaspaas iwivnayqia iviallplsf lgdmvgyrri ykiglvvfif tslacalsrs
      121 lemltfarva qglggaalms vntalirliy pqrflgrgmg insfvvavss aagptiaaai
      181 lslaswqwlf linvplgiva fvlamrflpp nsarskiirf dlpsaimnal tfgllitals
      241 gfaqgqstql vlaevaamlv vgfffvrrql tmpvpllpvd llriplfsls ictsicsfca
      301 qmlamvslpf flqsmmgrse vetgllltpw platmvmapl agyliekcha gllgaiglli
      361 macglfglal lpsspsdldi iwrmalcgag fglfqspnnh tivasapshr sggasgmlgt
      421 arllgqstga alvallfnll gnngthtall lagtlaivaa lisglrvtqp raa