aspartate 1-decarboxylase [Klebsiella pneumoniae].

LOCUS       WP_004227080             125 aa            linear   BCT 09-JUN-2024
ACCESSION   WP_004227080
VERSION     WP_004227080.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella pneumoniae
  ORGANISM  Klebsiella pneumoniae
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group;
            Klebsiella; Klebsiella pneumoniae complex.
REFERENCE   1  (residues 1 to 125)
  AUTHORS   Sun,Q., Li,X., Perez,L.M., Shi,W., Zhang,Y. and Sacchettini,J.C.
  TITLE     The molecular basis of pyrazinamide activity on Mycobacterium
            tuberculosis PanD
  JOURNAL   Nat Commun 11 (1), 339 (2020)
   PUBMED   31953389
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 125)
  AUTHORS   Shi,W., Chen,J., Feng,J., Cui,P., Zhang,S., Weng,X., Zhang,W. and
            Zhang,Y.
  TITLE     Aspartate decarboxylase (PanD) as a new target of pyrazinamide in
            Mycobacterium tuberculosis
  JOURNAL   Emerg Microbes Infect 3 (8), e58 (2014)
   PUBMED   26038753
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: TIGR00223.1
            Evidence Source    :: JCVI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..125
                     /organism="Klebsiella pneumoniae"
                     /db_xref="taxon:573"
     gene            1..125
                     /gene="panD"
     Protein         1..125
                     /product="aspartate 1-decarboxylase"
                     /EC_number="4.1.1.11"
                     /GO_function="GO:0004068 - aspartate 1-decarboxylase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006523 - alanine biosynthetic process
                     [Evidence IEA]"
                     /calculated_mol_wt=13634
     Region          1..125
                     /region_name="PRK05449"
                     /note="aspartate alpha-decarboxylase; Provisional"
                     /db_xref="CDD:180090"
     Site            order(1..6,8,10..11,19..22,36,38,41..42,46,48,51,53..57,
                     73..74,76..77,85,89..91,100)
                     /site_type="other"
                     /note="tetramerization interface [polypeptide binding]"
                     /db_xref="CDD:132994"
     Site            order(8,10,23..24,57)
                     /site_type="active"
                     /db_xref="CDD:132994"
ORIGIN      
        1 mrnmlqgklh rvkvtqadlh yegscaidqd fldaagilen etihlwnvtn gnrfstyaia
       61 aergsriisv ngaaahcasv gdiliiasfv tmsdeearsw qpniayfegd nemkrqakai
      121 pvqva