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isoleucine--tRNA ligase [Klebsiella pneumoniae].


LOCUS       WP_004221185             950 aa            linear   BCT 23-MAY-2024
ACCESSION   WP_004221185
VERSION     WP_004221185.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella pneumoniae
  ORGANISM  Klebsiella pneumoniae
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group;
            Klebsiella; Klebsiella pneumoniae complex.
REFERENCE   1  (residues 1 to 950)
  AUTHORS   Fukunaga,R. and Yokoyama,S.
  TITLE     Crystallization and preliminary X-ray crystallographic study of the
            editing domain of Thermus thermophilus isoleucyl-tRNA synthetase
            complexed with pre- and post-transfer editing-substrate analogues
  JOURNAL   Acta Crystallogr D Biol Crystallogr 60 (Pt 10), 1900-1902 (2004)
   PUBMED   15388946
REFERENCE   2  (residues 1 to 950)
  AUTHORS   Yanagisawa,T. and Kawakami,M.
  TITLE     How does Pseudomonas fluorescens avoid suicide from its antibiotic
            pseudomonic acid?: Evidence for two evolutionarily distinct
            isoleucyl-tRNA synthetases conferring self-defense
  JOURNAL   J Biol Chem 278 (28), 25887-25894 (2003)
   PUBMED   12672810
REFERENCE   3  (residues 1 to 950)
  AUTHORS   Nakama,T., Nureki,O. and Yokoyama,S.
  TITLE     Structural basis for the recognition of isoleucyl-adenylate and an
            antibiotic, mupirocin, by isoleucyl-tRNA synthetase
  JOURNAL   J Biol Chem 276 (50), 47387-47393 (2001)
   PUBMED   11584022
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: TIGR00392.1
            Evidence Source    :: JCVI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..950
                     /organism="Klebsiella pneumoniae"
                     /db_xref="taxon:573"
     gene            1..950
                     /gene="ileS"
     Protein         1..950
                     /product="isoleucine--tRNA ligase"
                     /EC_number="6.1.1.5"
                     /GO_function="GO:0000166 - nucleotide binding [Evidence
                     IEA]"
                     /GO_function="GO:0004822 - isoleucine-tRNA ligase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006428 - isoleucyl-tRNA aminoacylation
                     [Evidence IEA]"
                     /calculated_mol_wt=105799
     Region          16..942
                     /region_name="IleS"
                     /note="Isoleucyl-tRNA synthetase [Translation, ribosomal
                     structure and biogenesis]; COG0060"
                     /db_xref="CDD:439830"
ORIGIN      
        1 mfikpkygte nlmsdykstl nlpetgfpmr gdlakrepgm larwtdddly giiraakkgk
       61 ktfilhdgpp yangsihigh svnkilkdii vkskgltgyd spyvpgwdch glpielkveq
      121 eygkpgekft aaefrakcre yaaeqidgqr kdfirlgvlg dwshpyltmd fkteaniira
      181 lgkiignghl hkgakpvhwc vdcrsalaea eveyydktsp sidvafhavd kaavlakfgv
      241 advngpvslv iwtttpwtlp anraislspe fdyalvqvdg qalilakdlv esvmkrvgat
      301 dytilaavqg selelmrfkh pfldfdvpai lgdhvtldag tgavhtaggh gpddytisqk
      361 ygleianpvg pdgaylpgtw psldginvfk andiivemlr ergallhvek lqhsypccwr
      421 hkspiifrat pqwfvsmdqk glraqslkei kgvqwipdwg qariesmvan rpdwcisrqr
      481 twgvpmslfv hkethelhpr tlelmeevak rvevdgiqaw wdldsrdilg ddadsyekvp
      541 dtldvwfdsg sthssvvdvr pefaghaadm ylegsdqhrg wfmsslmist amkgkapyrq
      601 vlthgftvdg qgrkmsksig ntvspqdvmn klgadilrlw vastdytgem avsdeilkra
      661 adsyrrirnt arfllanlng fdpvkdmvkp eemvvldrwa vgcaqaaqed ilkayesydf
      721 hevvqrlmrf csiemgsfyl diikdrqyta kadsvarrsc qtalfhivea lvrwmapims
      781 ftadeiwgyl pgerekyvft gewyeglfgl addeamnddf wdellkvrge vnkvieqara
      841 dkkvggslea avtlyadadl aaklnalgde lrfvlltsga nvadyasasa daqqsellkg
      901 lkvalskaeg ekcprcwhyt tdigkvaeha eicgrcvsnv agdgeqrkfa