MFS transporter [Klebsiella pneumoniae].

LOCUS       WP_004220358             435 aa            linear   BCT 31-DEC-2024
ACCESSION   WP_004220358
VERSION     WP_004220358.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella pneumoniae
  ORGANISM  Klebsiella pneumoniae
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group;
            Klebsiella; Klebsiella pneumoniae complex.
REFERENCE   1  (residues 1 to 435)
  AUTHORS   Quistgaard,E.M., Low,C., Guettou,F. and Nordlund,P.
  TITLE     Understanding transport by the major facilitator superfamily (MFS):
            structures pave the way
  JOURNAL   Nat Rev Mol Cell Biol 17 (2), 123-132 (2016)
   PUBMED   26758938
REFERENCE   2  (residues 1 to 435)
  AUTHORS   Zhang,X.C., Zhao,Y., Heng,J. and Jiang,D.
  TITLE     Energy coupling mechanisms of MFS transporters
  JOURNAL   Protein Sci 24 (10), 1560-1579 (2015)
   PUBMED   26234418
REFERENCE   3  (residues 1 to 435)
  AUTHORS   Yan,N.
  TITLE     Structural Biology of the Major Facilitator Superfamily
            Transporters
  JOURNAL   Annu Rev Biophys 44, 257-283 (2015)
   PUBMED   26098515
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 13022776
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..435
                     /organism="Klebsiella pneumoniae"
                     /db_xref="taxon:573"
     Protein         1..435
                     /product="MFS transporter"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport
                     [Evidence IEA]"
                     /calculated_mol_wt=46633
     Region          1..402
                     /region_name="MFS_SV2_like"
                     /note="Metazoan Synaptic vesicle glycoprotein 2 (SV2) and
                     related small molecule transporters of the Major
                     Facilitator Superfamily; cd17316"
                     /db_xref="CDD:340874"
     Site            order(11..12,15..16,19,51,101..102,104..106,109,129,
                     132..133,136,249,252..253,256..258,261,288,292,342..343,
                     347,351,367,370..371,374..375,378)
                     /site_type="other"
                     /note="putative chemical substrate binding pocket
                     [chemical binding]"
                     /db_xref="CDD:340874"
ORIGIN      
        1 mfaivafgll vcwsnavggl ilaqlkelgw tdnsttatfs aittagmflg algggiigdk
       61 igrknafily eaihiiamvv gafspnmtfl iacrfvmgvg lgallvtlfa gfteympgrn
      121 rgtwssrvsf ignwsyplcs liamgltpli saewnwrvql lipavlslma tiiawrrfpe
      181 sprwlesrgr yaeaekvmra ieegvvlqtg kplppvvied dgkapravpy salltgvllk
      241 rvilgsfvli amnvvqytli nwlptifmtq ginlkdsivl ntmsmfgapf gifiamlvmd
      301 kiprktmgvg llvliaglgy iyslqtsmll itligfflit fvymyvcyas avyvpeiwpt
      361 eaklrgsgla navgrisgia apyavavlln gygvtgvfvl lgtvsiivai aiatigietk
      421 gvsveslgid avtsk