H(+)/Cl(-) exchange transporter ClcA [Klebsiella pneumoniae].

LOCUS       WP_004217649             503 aa            linear   BCT 17-OCT-2022
ACCESSION   WP_004217649
VERSION     WP_004217649.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella pneumoniae
  ORGANISM  Klebsiella pneumoniae
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group;
            Klebsiella; Klebsiella pneumoniae complex.
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: NF003640.0
            Evidence Source    :: NCBI Protein Cluster (PRK)
            Source Identifier  :: PRK05277
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Klebsiella pneumoniae"
                     /db_xref="taxon:573"
     gene            1..503
                     /gene="clcA"
     Protein         1..503
                     /product="H(+)/Cl(-) exchange transporter ClcA"
                     /GO_component="GO:0005886 - plasma membrane [Evidence
                     IEA]"
                     /GO_function="GO:0005247 - voltage-gated chloride channel
                     activity [Evidence IEA]"
                     /GO_process="GO:0006821 - chloride transport [Evidence
                     IEA]"
                     /GO_process="GO:0055085 - transmembrane transport
                     [Evidence IEA]"
                     /calculated_mol_wt=53669
     Region          67..484
                     /region_name="PRK05277"
                     /note="H(+)/Cl(-) exchange transporter ClcA"
                     /db_xref="CDD:235385"
     Site            order(137..141,177..181,386..390,476)
                     /site_type="active"
                     /note="Cl- selectivity filter [active]"
                     /db_xref="CDD:238504"
     Site            order(138,140,179..180,386..388,476)
                     /site_type="other"
                     /note="Cl- binding residues [ion binding]"
                     /db_xref="CDD:238504"
     Site            179
                     /site_type="active"
                     /note="pore gating glutamate residue [active]"
                     /db_xref="CDD:238504"
     Site            order(225,234,247,254,434,437,445,457,464..465,468)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:238504"
     Site            234
                     /site_type="active"
                     /note="H+/Cl- coupling transport residue [active]"
                     /db_xref="CDD:238504"
ORIGIN      
        1 mcrkgifltt qragaakmpl ssfvlpiidn gmkaetpsfe ahqfvrvrrg davrrliqrd
       61 ktplavlfma avvgtlaglv gvafeksvnw vqnqrigala qvadhwylvw plafilsall
      121 amvgyflvrr fapeaggsgi peiegaleel rpvrwwrvlp vkfvggmgtl gagmvlgreg
      181 pmvqlggnig rmvldvfrmr spearhtlla tgaasglsaa fnaplagilf iieemrpqfr
      241 ynlisikavf tgvimssivf rifngeaaii evgklsnapv ntlwlylvlg mlfgcfgplf
      301 nflvlrtqdl fqrihggnik kwvligglig glcgllglmq psavgggfnl ipiaaagnfs
      361 vglllfifia rvvttlicfs sgapggifap mlalgtllgt afgmaaiplf payhldagtf
      421 aiagmgalla asvrapltgi vlvlemtdny qlilpmiitc lgatllaqfl ggkplystil
      481 qrtlakqeae qaakaqqapr ent