MULTISPECIES: NAD-dependent epimerase/dehydratase family protein

LOCUS       WP_004200255             331 aa            linear   BCT 02-MAR-2025
            [Klebsiella].
ACCESSION   WP_004200255
VERSION     WP_004200255.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella
  ORGANISM  Klebsiella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group.
REFERENCE   1  (residues 1 to 331)
  AUTHORS   Thoden,J.B., Hegeman,A.D., Wesenberg,G., Chapeau,M.C., Frey,P.A.
            and Holden,H.M.
  TITLE     Structural analysis of UDP-sugar binding to UDP-galactose
            4-epimerase from Escherichia coli
  JOURNAL   Biochemistry 36 (21), 6294-6304 (1997)
   PUBMED   9174344
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: NF013530.6
            Evidence Source    :: EMBL-EBI
            Source Identifier  :: PF01370.27
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..331
                     /organism="Klebsiella"
                     /db_xref="taxon:570"
     Protein         1..331
                     /product="NAD-dependent epimerase/dehydratase family
                     protein"
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /calculated_mol_wt=36028
     Region          6..313
                     /region_name="Rossmann-fold NAD(P)(+)-binding proteins"
                     /note="A large family of proteins that share a
                     Rossmann-fold NAD(P)H/NAD(P)(+) binding (NADB) domain. The
                     NADB domain is found in numerous dehydrogenases of
                     metabolic pathways such as glycolysis, and many other
                     redox enzymes. NAD binding involves numerous...; cl21454"
                     /db_xref="CDD:473865"
     Site            order(11,13..14,16,35..37,73..75,107..109,129,133,
                     159..162)
                     /site_type="other"
                     /note="NAD(P) binding site [chemical binding]"
                     /db_xref="CDD:187540"
     Site            order(86,109,129,133)
                     /site_type="active"
                     /db_xref="CDD:187540"
ORIGIN      
        1 mnssgkvlil gasggiggev arrlvadnwq vralkrgaqm rdpedgiqwi agdaldggqv
       61 aaaaagcdvi vhavnppgyr hwrqqvlpml rntlqaaerq ralvvlpgtv ynygpdafpl
      121 iaeeaaqqpv trkgairvam elalkdyvqr ggralivrag dffgpragnn wfsqglvkpg
      181 qlpriisypg aigvghqwaw lpdvaatiaa llarrrelep farfhmqghw dpdgsemsqa
      241 iqrvvarygg ravvksfpww lvkmaapfna tlremvemhy lwrlpvrlrn dklvdflgae
      301 phtpldsavy qtlqglgclp againqeage a