MULTISPECIES: MFS transporter [Klebsiella].

LOCUS       WP_004199937             410 aa            linear   BCT 01-JAN-2025
ACCESSION   WP_004199937
VERSION     WP_004199937.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella
  ORGANISM  Klebsiella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group.
REFERENCE   1  (residues 1 to 410)
  AUTHORS   Quistgaard,E.M., Low,C., Guettou,F. and Nordlund,P.
  TITLE     Understanding transport by the major facilitator superfamily (MFS):
            structures pave the way
  JOURNAL   Nat Rev Mol Cell Biol 17 (2), 123-132 (2016)
   PUBMED   26758938
REFERENCE   2  (residues 1 to 410)
  AUTHORS   Zhang,X.C., Zhao,Y., Heng,J. and Jiang,D.
  TITLE     Energy coupling mechanisms of MFS transporters
  JOURNAL   Protein Sci 24 (10), 1560-1579 (2015)
   PUBMED   26234418
REFERENCE   3  (residues 1 to 410)
  AUTHORS   Yan,N.
  TITLE     Structural Biology of the Major Facilitator Superfamily
            Transporters
  JOURNAL   Annu Rev Biophys 44, 257-283 (2015)
   PUBMED   26098515
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 13022776
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..410
                     /organism="Klebsiella"
                     /db_xref="taxon:570"
     Protein         1..410
                     /product="MFS transporter"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport
                     [Evidence IEA]"
                     /calculated_mol_wt=44498
     Region          12..387
                     /region_name="MFS_SV2_like"
                     /note="Metazoan Synaptic vesicle glycoprotein 2 (SV2) and
                     related small molecule transporters of the Major
                     Facilitator Superfamily; cd17316"
                     /db_xref="CDD:340874"
     Site            order(22..23,26..27,30,62,112..113,115..117,120,140,
                     143..144,147,220,223..224,227..229,232,260,264,313..314,
                     318,322,338,341..342,345..346,349)
                     /site_type="other"
                     /note="putative chemical substrate binding pocket
                     [chemical binding]"
                     /db_xref="CDD:340874"
ORIGIN      
        1 mhgwtsrqrn aaiasflswt ldafdffllv fllsdiahsf hvdleevtla illtlavrpv
       61 galifgraae kfgrkpilml nivffsafel lsaaapslml ffllrvlygv amggiwgvas
      121 slametipdr srglmsglfq agypfgylla avaygllfeq lgwrgmfvig aapvlllpfi
      181 yfcveespvw qaarqnkest allpvlrshw klclylvvlm aafnffshgt qdlypvflkv
      241 qhgfepktvs iiavcynias iiggvffgsl sekigrrkai miaallalpv iplwafasgs
      301 lalgagaflm qfmvqgawgv iptwlnelvp antravlpgf vyqlgnllas vnatlqasia
      361 qhhehnygla malvagtvai vitvltffgr egrviqsaga ghhqplstsr