MULTISPECIES: putative bifunctional diguanylate

LOCUS       WP_004199859             551 aa            linear   BCT 24-DEC-2024
            cyclase/phosphodiesterase [Klebsiella].
ACCESSION   WP_004199859
VERSION     WP_004199859.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella
  ORGANISM  Klebsiella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group.
REFERENCE   1  (residues 1 to 551)
  AUTHORS   Romling,U. and Amikam,D.
  TITLE     Cyclic di-GMP as a second messenger
  JOURNAL   Curr Opin Microbiol 9 (2), 218-228 (2006)
   PUBMED   16530465
REFERENCE   2  (residues 1 to 551)
  AUTHORS   Romling,U., Gomelsky,M. and Galperin,M.Y.
  TITLE     C-di-GMP: the dawning of a novel bacterial signalling system
  JOURNAL   Mol Microbiol 57 (3), 629-639 (2005)
   PUBMED   16045609
REFERENCE   3  (residues 1 to 551)
  AUTHORS   Simm,R., Morr,M., Kader,A., Nimtz,M. and Romling,U.
  TITLE     GGDEF and EAL domains inversely regulate cyclic di-GMP levels and
            transition from sessility to motility
  JOURNAL   Mol Microbiol 53 (4), 1123-1134 (2004)
   PUBMED   15306016
REFERENCE   4  (residues 1 to 551)
  AUTHORS   Galperin,M.Y., Nikolskaya,A.N. and Koonin,E.V.
  TITLE     Novel domains of the prokaryotic two-component signal transduction
            systems
  JOURNAL   FEMS Microbiol Lett 203 (1), 11-21 (2001)
   PUBMED   11557134
  REMARK    Erratum:[FEMS Microbiol Lett 2001 Oct 16;204(1):213-4]
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 11472025
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..551
                     /organism="Klebsiella"
                     /db_xref="taxon:570"
     Protein         1..551
                     /product="putative bifunctional diguanylate
                     cyclase/phosphodiesterase"
                     /EC_number="2.7.7.65"
                     /GO_component="GO:0005886 - plasma membrane [Evidence
                     IEA]"
                     /GO_function="GO:0005525 - GTP binding [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0052621 - diguanylate cyclase activity
                     [Evidence IEA]"
                     /GO_function="GO:0071111 - cyclic-guanylate-specific
                     phosphodiesterase activity [Evidence IEA]"
                     /calculated_mol_wt=62479
     Region          4..550
                     /region_name="COG5001"
                     /note="Cyclic di-GMP metabolism protein, combines GGDEF
                     and EAL domains with a 6TM membrane domain [Signal
                     transduction mechanisms]"
                     /db_xref="CDD:444025"
ORIGIN      
        1 msndhltdia yrhfiesvkd yaiymlsadg tviswnegar rakgylsdei igryfglfys
       61 eaeqlsgvpa knleialrsg qfegegwryr kdgsrfwahv midtirdeqn tllgfakitr
      121 diseqkaind riawmaryda ltglpnrvef ferveklitg ndarrfaift idldkfkein
      181 dlqghligdq llqrvagavl ktlqkeemva rfggdefvav kpfsdegevd afaarlwrcf
      241 sgkqtfaate vvlsasigis vypedgtdin tilsnsdlam yrakssldhk icwyeremdd
      301 ktrqrnmmaa dirrgihage fslhyqairn ikdrsitgye allrwqhpql gtippdvfip
      361 iaeesgaivp lgywvleqvc neslenglnr kvsvnispvq lrhrsfiekv reilmrtayp
      421 vsllefevte tafvinkqla fsvlhhlqkm gisialddfg tgysslsmlr dfhfdvikld
      481 rsfmtdvesn pqvrsfvrai islgnsintp liaegvetag qlqileeegc demqgflfge
      541 pvdikhlpdr r