bifunctional phosphopantothenoylcysteine

LOCUS       WP_004198431             405 aa            linear   BCT 17-JUN-2024
            decarboxylase/phosphopantothenate--cysteine ligase CoaBC
            [Klebsiella pneumoniae].
ACCESSION   WP_004198431
VERSION     WP_004198431.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella pneumoniae
  ORGANISM  Klebsiella pneumoniae
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group;
            Klebsiella; Klebsiella pneumoniae complex.
REFERENCE   1  (residues 1 to 405)
  AUTHORS   Strauss,E., Kinsland,C., Ge,Y., McLafferty,F.W. and Begley,T.P.
  TITLE     Phosphopantothenoylcysteine synthetase from Escherichia coli.
            Identification and characterization of the last unidentified
            coenzyme A biosynthetic enzyme in bacteria
  JOURNAL   J Biol Chem 276 (17), 13513-13516 (2001)
   PUBMED   11278255
REFERENCE   2  (residues 1 to 405)
  AUTHORS   Spitzer,E.D., Jimenez-Billini,H.E. and Weiss,B.
  TITLE     beta-Alanine auxotrophy associated with dfp, a locus affecting DNA
            synthesis in Escherichia coli
  JOURNAL   J Bacteriol 170 (2), 872-876 (1988)
   PUBMED   3123465
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: TIGR00521.1
            Evidence Source    :: JCVI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..405
                     /organism="Klebsiella pneumoniae"
                     /db_xref="taxon:573"
     gene            1..405
                     /gene="coaBC"
     Protein         1..405
                     /product="bifunctional phosphopantothenoylcysteine
                     decarboxylase/phosphopantothenate--cysteine ligase CoaBC"
                     /EC_number="4.1.1.36"
                     /EC_number="6.3.2.5"
                     /GO_function="GO:0004632 - phosphopantothenate--cysteine
                     ligase activity [Evidence IEA]"
                     /GO_function="GO:0004633 - phosphopantothenoylcysteine
                     decarboxylase activity [Evidence IEA]"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /GO_process="GO:0015937 - coenzyme A biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0015941 - pantothenate catabolic process
                     [Evidence IEA]"
                     /calculated_mol_wt=43383
     Region          1..401
                     /region_name="PRK05579"
                     /note="bifunctional phosphopantothenoylcysteine
                     decarboxylase/phosphopantothenate synthase; Validated"
                     /db_xref="CDD:235513"
ORIGIN      
        1 mmtlagkkiv lgvsggiaay ktpelvrrlr ergaevrvam teaakafitp lslqavsgyp
       61 vsdslldpaa eaamghielg kwadlvilap atadliarva agmandlvst iclatpspva
      121 vvpamnqqmy raqatqhnlq tlatrglllw gpdsgsqacg dvgpgrmldp ltivdmaaqh
      181 faspvkdlqh lnlmitagpt repldpvryi tnhssgkmgf aiaaaaaqrg anvtlisgpv
      241 slptppfvqr idvttaleme aavqagaqqq hifigcaava dyraaviaed kikkqgdelt
      301 ikmvknpdiv agvaalkshr pyvvgfaaet nyveeyarqk rarknldlic andvsqpnqg
      361 fnsdsnalhl fwqdgekrlp lerkellgql lldeivtryd eknrr