Unfortunately due to lack of commercial feasibility, the SkyBLAST service has been suspended from December 1st, 2025.
All subscriptions for paid accounts have been paused. For further information or enquiries, please email [email protected]
LOCUS WP_004196289 636 aa linear BCT 24-DEC-2024 cyclase/phosphodiesterase [Klebsiella]. ACCESSION WP_004196289 VERSION WP_004196289.1 KEYWORDS RefSeq. SOURCE Klebsiella ORGANISM Klebsiella Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group. REFERENCE 1 (residues 1 to 636) AUTHORS Romling,U. and Amikam,D. TITLE Cyclic di-GMP as a second messenger JOURNAL Curr Opin Microbiol 9 (2), 218-228 (2006) PUBMED 16530465 REFERENCE 2 (residues 1 to 636) AUTHORS Romling,U., Gomelsky,M. and Galperin,M.Y. TITLE C-di-GMP: the dawning of a novel bacterial signalling system JOURNAL Mol Microbiol 57 (3), 629-639 (2005) PUBMED 16045609 REFERENCE 3 (residues 1 to 636) AUTHORS Simm,R., Morr,M., Kader,A., Nimtz,M. and Romling,U. TITLE GGDEF and EAL domains inversely regulate cyclic di-GMP levels and transition from sessility to motility JOURNAL Mol Microbiol 53 (4), 1123-1134 (2004) PUBMED 15306016 REFERENCE 4 (residues 1 to 636) AUTHORS Galperin,M.Y., Nikolskaya,A.N. and Koonin,E.V. TITLE Novel domains of the prokaryotic two-component signal transduction systems JOURNAL FEMS Microbiol Lett 203 (1), 11-21 (2001) PUBMED 11557134 REMARK Erratum:[FEMS Microbiol Lett 2001 Oct 16;204(1):213-4] COMMENT REFSEQ: This record represents a single, non-redundant, protein sequence which may be annotated on many different RefSeq genomes from the same, or different, species. ##Evidence-For-Name-Assignment-START## Evidence Category :: Conserved Domain (CDD) Evidence Accession :: Domain architecture ID 11472025 Evidence Source :: NCBI SPARCLE ##Evidence-For-Name-Assignment-END## COMPLETENESS: full length. FEATURES Location/Qualifiers source 1..636 /organism="Klebsiella" /db_xref="taxon:570" Protein 1..636 /product="putative bifunctional diguanylate cyclase/phosphodiesterase" /EC_number="2.7.7.65" /GO_component="GO:0005886 - plasma membrane [Evidence IEA]" /GO_function="GO:0005525 - GTP binding [Evidence IEA]" /GO_function="GO:0046872 - metal ion binding [Evidence IEA]" /GO_function="GO:0052621 - diguanylate cyclase activity [Evidence IEA]" /GO_function="GO:0071111 - cyclic-guanylate-specific phosphodiesterase activity [Evidence IEA]" /calculated_mol_wt=72214 Region 51..634 /region_name="COG5001" /note="Cyclic di-GMP metabolism protein, combines GGDEF and EAL domains with a 6TM membrane domain [Signal transduction mechanisms]" /db_xref="CDD:444025" ORIGIN 1 mnriltaiil slfvvtgyit ylvherqsel qkftrytdsw smsqmvseym rlesrlagma 61 igaegadhde vrlrleimms qiellqegdl gkfinkseqr ktvvatlirn lhlldkqvdt 121 mtpeqvrqil pvlseldgpl tsmaaatltq dinivnithd kiqhlyyiys visilliamc 181 itlgllmlrq nnnlrrahvr mktlandlqa skeklqvqnr rlqydayhds ltgmpnrlsf 241 wqrlqeivnq vrpykgcavv mlfdldsfkd vndtlghdag dkllqdlasr lsffrktset 301 lyrlggdefa mlsydlteem aleranvire kisqpyqiyd aqinidacig ivisdgesrt 361 dylykcadla lyeakkegsg hvqifrpgml qrlqenksfe ddllqalahd efkvyyqpia 421 dtvtreiygy ealvrwfhpv rgavpptvfi pvaekiglin algewvlkta caeaaswatp 481 lkvsvnvspi qlmntsltdt iievlhqtgl dprrldleit esdvfnentr sleilsqlre 541 qgiqisiddf gtgysslsrl syfpfdkiki drsfvinipe qkddldivrl iismgkslhm 601 rivaegvete eqlaslqalg cdlvqgylig kpsplr